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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Thy1-cre)1Vln
transgene insertion 1, Fred Van Leuven
MGI:2684620
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Ifngr1tm1Dmer/Ifngr1tm1Dmer
Tg(Thy1-cre)1Vln/0
B6.Cg-Ifngr1tm1Dmer Tg(Thy1-cre)1Vln MGI:5552977
cn2
Panx1tm1Vshe/Panx1tm1Vshe
Tg(Thy1-cre)1Vln/0
B6.Cg-Panx1tm1Vshe Tg(Thy1-cre)1Vln MGI:5488659
cn3
Dscamtm1Pfu/Dscamtm1Pfu
Tg(Thy1-cre)1Vln/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N MGI:5305037
cn4
Psen1tm1Vln/Psen1tm1Vln
Tg(Thy1-cre)1Vln/0
involves: FVB/N MGI:2684657
cn5
Psen1tm1Vln/Psen1tm1Vln
Tg(Thy1-APPLon)2Vln/0
Tg(Thy1-cre)1Vln/0
involves: FVB/N MGI:2684658


Genotype
MGI:5552977
cn1
Allelic
Composition
Ifngr1tm1Dmer/Ifngr1tm1Dmer
Tg(Thy1-cre)1Vln/0
Genetic
Background
B6.Cg-Ifngr1tm1Dmer Tg(Thy1-cre)1Vln
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifngr1tm1Dmer mutation (0 available); any Ifngr1 mutation (19 available)
Tg(Thy1-cre)1Vln mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• mice fail to develop viral deja vu disease unlike wild-type mice




Genotype
MGI:5488659
cn2
Allelic
Composition
Panx1tm1Vshe/Panx1tm1Vshe
Tg(Thy1-cre)1Vln/0
Genetic
Background
B6.Cg-Panx1tm1Vshe Tg(Thy1-cre)1Vln
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Panx1tm1Vshe mutation (1 available); any Panx1 mutation (18 available)
Tg(Thy1-cre)1Vln mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• following ischemia/reperfusion injury
• following ischemia/reperfusion injury

homeostasis/metabolism
• following ischemia/reperfusion injury, retina exhibit reduced retinal ganglion cell (RGC) loss and increased RGC and neuronal survival with less apoptosis compared with wild-type mice

vision/eye
• following ischemia/reperfusion injury

cellular
• following ischemia/reperfusion injury




Genotype
MGI:5305037
cn3
Allelic
Composition
Dscamtm1Pfu/Dscamtm1Pfu
Tg(Thy1-cre)1Vln/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dscamtm1Pfu mutation (0 available); any Dscam mutation (47 available)
Tg(Thy1-cre)1Vln mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• aggregation of recombined retinal ganglion cells

nervous system
• aggregation of recombined retinal ganglion cells




Genotype
MGI:2684657
cn4
Allelic
Composition
Psen1tm1Vln/Psen1tm1Vln
Tg(Thy1-cre)1Vln/0
Genetic
Background
involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psen1tm1Vln mutation (2 available); any Psen1 mutation (28 available)
Tg(Thy1-cre)1Vln mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• mice do not display any behavioral or cognitive deficits

nervous system
N
• brains of 6 month-old mice do not show any morphological abnormalities like cerebral hemorrhages, cavities or tumors; no defects are observed up to 2 years of age
• levels of amyloid beta-40 and -42 (Abeta40, Abeta42) are reduced relative to controls; C-terminal fragments of APP accumulate in brains
• initial phase of the slope of fEPSP is lower (168% vs 221% in controls) 15 minutes after tetanic stimulation; slope of fEPSP progressively increases to approach control levels 2 hours following stimulation

homeostasis/metabolism
• levels of amyloid beta-40 and -42 (Abeta40, Abeta42) are reduced relative to controls; C-terminal fragments of APP accumulate in brains

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease 3 607822 J:87229
Alzheimer Disease; AD 104300 J:87229




Genotype
MGI:2684658
cn5
Allelic
Composition
Psen1tm1Vln/Psen1tm1Vln
Tg(Thy1-APPLon)2Vln/0
Tg(Thy1-cre)1Vln/0
Genetic
Background
involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psen1tm1Vln mutation (2 available); any Psen1 mutation (28 available)
Tg(Thy1-APPLon)2Vln mutation (0 available)
Tg(Thy1-cre)1Vln mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• retention of object recognition is normal at 1 hr after training but testing of animals 3 hours after familiarization with an object reveals significant impairment relative to controls

nervous system
N
• no thioflavin-S-reactive amyloid plaques or diffuse amyloid deposits are detected in mice up to 18 months of age
• with tetanic stimulation of hippocampal slices, after an initial slight decrease, the slope of the fEPSP approached control levels; LTP in transgenic brain slices is comparable to controls





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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory