Mouse Genome Informatics
cn1
    Ifngr1tm1Dmer/Ifngr1tm1Dmer
Tg(Thy1-cre)1Vln/0

B6.Cg-Ifngr1tm1Dmer Tg(Thy1-cre)1Vln
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• mice fail to develop viral deja vu disease unlike wild-type mice


Mouse Genome Informatics
cn2
    Panx1tm1Vshe/Panx1tm1Vshe
Tg(Thy1-cre)1Vln/0

B6.Cg-Panx1tm1Vshe Tg(Thy1-cre)1Vln
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• following ischemia/reperfusion injury
• following ischemia/reperfusion injury

homeostasis/metabolism
• following ischemia/reperfusion injury, retina exhibit reduced retinal ganglion cell (RGC) loss and increased RGC and neuronal survival with less apoptosis compared with wild-type mice

vision/eye
• following ischemia/reperfusion injury

cellular
• following ischemia/reperfusion injury


Mouse Genome Informatics
cn3
    Dscamtm1Pfu/Dscamtm1Pfu
Tg(Thy1-cre)1Vln/0

involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
vision/eye
• aggregation of recombined retinal ganglion cells

nervous system
• aggregation of recombined retinal ganglion cells


Mouse Genome Informatics
cn4
    Psen1tm1Vln/Psen1tm1Vln
Tg(Thy1-cre)1Vln/0

involves: FVB/N
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
behavior/neurological
N
• mice do not display any behavioral or cognitive deficits (J:87229)

nervous system
N
• brains of 6 month-old mice do not show any morphological abnormalities like cerebral hemorrhages, cavities or tumors; no defects are observed up to 2 years of age (J:87229)
• levels of amyloid beta-40 and -42 (Abeta40, Abeta42) are reduced relative to controls; C-terminal fragments of APP accumulate in brains
• initial phase of the slope of fEPSP is lower (168% vs 221% in controls) 15 minutes after tetanic stimulation; slope of fEPSP progressively increases to approach control levels 2 hours following stimulation

homeostasis/metabolism
• levels of amyloid beta-40 and -42 (Abeta40, Abeta42) are reduced relative to controls; C-terminal fragments of APP accumulate in brains

Mouse Models of Human Disease
OMIM IDRef(s)
Alzheimer Disease 3 607822 J:87229
Alzheimer Disease; AD 104300 J:87229


Mouse Genome Informatics
cn5
    Psen1tm1Vln/Psen1tm1Vln
Tg(Thy1-APPLon)2Vln/0
Tg(Thy1-cre)1Vln/0

involves: FVB/N
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
behavior/neurological
• retention of object recognition is normal at 1 hr after training but testing of animals 3 hours after familiarization with an object reveals significant impairment relative to controls

nervous system
N
• no thioflavin-S-reactive amyloid plaques or diffuse amyloid deposits are detected in mice up to 18 months of age (J:87229)
• with tetanic stimulation of hippocampal slices, after an initial slight decrease, the slope of the fEPSP approached control levels; LTP in transgenic brain slices is comparable to controls