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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Psen1tm1Vln
targeted mutation 1, Fred Van Leuven
MGI:2684616
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Psen1tm1Vln/Psen1tm1Vln Not Specified MGI:2684624
cn2
Psen1tm1Vln/Psen1tm1Vln
Tg(Thy1-cre)1Vln/0
involves: FVB/N MGI:2684657
cn3
Psen1tm1Vln/Psen1tm1Vln
Tg(Thy1-APPLon)2Vln/0
Tg(Thy1-cre)1Vln/0
involves: FVB/N MGI:2684658


Genotype
MGI:2684624
hm1
Allelic
Composition
Psen1tm1Vln/Psen1tm1Vln
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psen1tm1Vln mutation (2 available); any Psen1 mutation (28 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype




Genotype
MGI:2684657
cn2
Allelic
Composition
Psen1tm1Vln/Psen1tm1Vln
Tg(Thy1-cre)1Vln/0
Genetic
Background
involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psen1tm1Vln mutation (2 available); any Psen1 mutation (28 available)
Tg(Thy1-cre)1Vln mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• mice do not display any behavioral or cognitive deficits

nervous system
N
• brains of 6 month-old mice do not show any morphological abnormalities like cerebral hemorrhages, cavities or tumors; no defects are observed up to 2 years of age
• levels of amyloid beta-40 and -42 (Abeta40, Abeta42) are reduced relative to controls; C-terminal fragments of APP accumulate in brains
• initial phase of the slope of fEPSP is lower (168% vs 221% in controls) 15 minutes after tetanic stimulation; slope of fEPSP progressively increases to approach control levels 2 hours following stimulation

homeostasis/metabolism
• levels of amyloid beta-40 and -42 (Abeta40, Abeta42) are reduced relative to controls; C-terminal fragments of APP accumulate in brains

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease 3 607822 J:87229
Alzheimer Disease; AD 104300 J:87229




Genotype
MGI:2684658
cn3
Allelic
Composition
Psen1tm1Vln/Psen1tm1Vln
Tg(Thy1-APPLon)2Vln/0
Tg(Thy1-cre)1Vln/0
Genetic
Background
involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psen1tm1Vln mutation (2 available); any Psen1 mutation (28 available)
Tg(Thy1-APPLon)2Vln mutation (0 available)
Tg(Thy1-cre)1Vln mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• retention of object recognition is normal at 1 hr after training but testing of animals 3 hours after familiarization with an object reveals significant impairment relative to controls

nervous system
N
• no thioflavin-S-reactive amyloid plaques or diffuse amyloid deposits are detected in mice up to 18 months of age
• with tetanic stimulation of hippocampal slices, after an initial slight decrease, the slope of the fEPSP approached control levels; LTP in transgenic brain slices is comparable to controls





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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory