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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Hcn4tm1.1Jsr
targeted mutation 1.1, Juliane Stieber
MGI:2684538
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Hcn4tm1.1Jsr/Hcn4tm1.1Jsr involves: 129/Sv * C57BL/6 MGI:2684590


Genotype
MGI:2684590
hm1
Allelic
Composition
Hcn4tm1.1Jsr/Hcn4tm1.1Jsr
Genetic
Background
involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hcn4tm1.1Jsr mutation (0 available); any Hcn4 mutation (67 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• homozygous embryos died between E9.5 and E11.5

cardiovascular system
• basal contraction rate of the embryonic heart is significantly reduced
• 75-90% reduction of cation current (If) at R9.0, E9.5, E10.5
• lack of pacemaker-like action potentials





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory