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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Twist1Pas
Pasteur
MGI:2684436
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Twist1Pas/Twist1Pas involves: C57BL/6 * PDT/Pas MGI:2684458
ht2
 		Twist1Pas/Twist1+ involves: C57BL/6 * PDT/Pas MGI:2684461


Genotype
MGI:2684458
hm1
Allelic
Composition		 Twist1Pas/Twist1Pas
Genetic
Background		 involves: C57BL/6 * PDT/Pas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Twist1Pas mutation (1 available); any Twist1 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, incomplete penetrance ( J:86815 )
• 90% penetrant in (PDT/Pas x C57BL/6) F2 offspring.

nervous system

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Saethre-Chotzen syndrome DOID:14768 OMIM:101400
OMIM:180750
 J:86815




Genotype
MGI:2684461
ht2
Allelic
Composition		 Twist1Pas/Twist1+
Genetic
Background		 involves: C57BL/6 * PDT/Pas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Twist1Pas mutation (1 available); any Twist1 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Polydactyly in the right hindlimb of Twist1Pas/Twist1+ mice

craniofacial
cleft palate ( J:86815 )
• cleft palate and other defects related to craniogenesis are observed approximately 5 % of the time and always in conjunction with polydactyly

limbs/digits/tail
polydactyly ( J:86815 )
• alterations in pattern development leads to the formation of one, but rarely two extra digits in the preaxial part of one of the hindlimbs, rarely both without left right preference
• penetrance varies with genetic background but is never complete
• genetic analysis reveals that this allele is sufficient to produce the polydactyly phenotype at a low frequency

digestive/alimentary system
cleft palate ( J:86815 )
• cleft palate and other defects related to craniogenesis are observed approximately 5 % of the time and always in conjunction with polydactyly

growth/size/body
cleft palate ( J:86815 )
• cleft palate and other defects related to craniogenesis are observed approximately 5 % of the time and always in conjunction with polydactyly

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Saethre-Chotzen syndrome DOID:14768 OMIM:101400
OMIM:180750
 J:86815




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory