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Allele Symbol Allele Name Allele ID |
Gata3tm1Iho targeted mutation 1, I-Cheng Ho MGI:2683927 |
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| Summary |
5 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in the lungs of mice infected with N. brasiliensis
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• mice exhibit reduced helminth Nippostrongylus brasiliensis expulsion compared with control mice
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• in the lungs of mice infected with N. brasiliensis
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• fewer than the expected numbers (6.5% vs 12.5%) of mutants are born, indicating partial prenatal lethality; time of lethality not determined
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• those double negative (DN) 3 cells that are able to develop into DN4 cells, exhibit increased apoptosis compared to controls
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• decrease in total thymocyte number at 4-6 weeks of age
• 10-fold reduction in the number of alpha/beta TCR+ thymocytes
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• double negative (DN) thymocytes fail to develop into large active double positive thymocytes
• accumulation of cells in the CD44-CD25+ DN3 stage and decreased CD44-CD25- DN4 cells, indicating a partial arrest at the DN3 to DN4 transition
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• reduction in the CD4/CD8 ratio (1.33 vs 3-4 in controls)
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• variable numbers of total SP CD8 cell numbers, with a decrease in most cases but increases in other cases
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• those double negative (DN) 3 cells that are able to develop into DN4 cells, exhibit increased apoptosis compared to controls
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• decrease in total thymocyte number at 4-6 weeks of age
• 10-fold reduction in the number of alpha/beta TCR+ thymocytes
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• double negative (DN) thymocytes fail to develop into large active double positive thymocytes
• accumulation of cells in the CD44-CD25+ DN3 stage and decreased CD44-CD25- DN4 cells, indicating a partial arrest at the DN3 to DN4 transition
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• reduction in the CD4/CD8 ratio (1.33 vs 3-4 in controls)
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• variable numbers of total SP CD8 cell numbers, with a decrease in most cases but increases in other cases
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• those double negative (DN) 3 cells that are able to develop into DN4 cells, exhibit increased apoptosis compared to controls
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• decrease in total thymocyte number at 4-6 weeks of age
• 10-fold reduction in the number of alpha/beta TCR+ thymocytes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 10-fold reduction
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• partial impairment in generation of double positive cells
• partial arrest at the double negative 3 (DN3) to double negative 4 (DN4) transition
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• 10-fold reduction
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• 10-fold reduction
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• partial impairment in generation of double positive cells
• partial arrest at the double negative 3 (DN3) to double negative 4 (DN4) transition
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• 10-fold reduction
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• severe reduction in single positive (SP) CD4 cells and no enrichment of SP CD8 cells
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• severe reduction in single positive (SP) CD4 cells and no enrichment of SP CD8 cells
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• thymocytes do not mature to the single positive stage
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• percentage of single positive CD4 thymocytes is reduced from 10-15% in controls to 3% or less in mutants
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• thymocytes do not mature to the single positive stage
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• percentage of single positive CD4 thymocytes is reduced from 10-15% in controls to 3% or less in mutants
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/09/2024 MGI 6.23 |
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