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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Icostm1Shr
targeted mutation 1, Arlene H Sharpe
MGI:2683665
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Icostm1Shr/Icostm1Shr Not Specified MGI:2683669


Genotype
MGI:2683669
hm1
Allelic
Composition
Icostm1Shr/Icostm1Shr
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Icostm1Shr mutation (2 available); any Icos mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• after immunization with alum or incomplete Freund's adjuvant, germinal centers were reduced in size and number
• organization of germinal centers remained normal
• IgM response remained normal
• production of IgE extremely low or absent
• IgG3 levels were slightly elevated
• after immunization with alum or incomplete Freund's adjuvant
• reduction of IgG1 levels to under 2% of normal
• reduction of IgG2a level to around 6% of normal

immune system
• after immunization with alum or incomplete Freund's adjuvant, germinal centers were reduced in size and number
• organization of germinal centers remained normal
• IgM response remained normal
• production of IgE extremely low or absent
• IgG3 levels were slightly elevated
• after immunization with alum or incomplete Freund's adjuvant
• reduction of IgG1 levels to under 2% of normal
• reduction of IgG2a level to around 6% of normal
• Il-4 levels not detectable
• Il-10 levels not detectable

homeostasis/metabolism
• Il-4 levels not detectable
• Il-10 levels not detectable

Mouse Models of Human Disease
OMIM ID Ref(s)
Immunodeficiency, Common Variable, 1; CVID1 607594 J:87124





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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory