About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ubr2tm1Ytkw
targeted mutation 1, Yong Tae Kwon
MGI:2682037
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ubr2tm1Ytkw/Ubr2tm1Ytkw involves: 129S1/Sv MGI:2682598
hm2
Ubr2tm1Ytkw/Ubr2tm1Ytkw involves: 129S1/Sv * C57BL/6 MGI:2682595
hm3
Ubr2tm1Ytkw/Ubr2tm1Ytkw involves: 129S1/Sv * CD-1 MGI:2682597
cx4
Ubr1tm1Avar/Ubr1tm1Avar
Ubr2tm1Ytkw/Ubr2tm1Ytkw
involves: 129S1/Sv * C57BL/6 MGI:3663588


Genotype
MGI:2682598
hm1
Allelic
Composition
Ubr2tm1Ytkw/Ubr2tm1Ytkw
Genetic
Background
involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ubr2tm1Ytkw mutation (0 available); any Ubr2 mutation (86 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• very few homozygotes of either sex produced

reproductive system
• testis degeneration not as severe as on the mixed background with C57BL/6

endocrine/exocrine glands
• testis degeneration not as severe as on the mixed background with C57BL/6




Genotype
MGI:2682595
hm2
Allelic
Composition
Ubr2tm1Ytkw/Ubr2tm1Ytkw
Genetic
Background
involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ubr2tm1Ytkw mutation (0 available); any Ubr2 mutation (86 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• lower than expected numbers of homozygous females born

growth/size/body
• rare surviving females were growth retarded by 2 months of age

reproductive system
• testes degeneration starts around 3 weeks and continues past 8 weeks
• at 8 weeks, testes are about 1/4 normal weight
• epididymal sperm count averaged about 30% lower
• low levels of sperm in the epididymis at 8 weeks and that sperm was abnormal
• spermatogenesis stops at or before the pachytene stage of prophase I
• rare surviving females showed reduced fertility
• males were infertile but in early generations and later phenotype ameliorated somewhat

embryo
• 6 out of 13 E7.5 female embryos were growth arrested or deformed
• increased apoptosis in E9.5 and E11.5 growth arrested female embryos
• no abnormality in apoptosis if growth was normal
• increased apoptosis in E9.5 and E11.5 growth arrested female embryos
• no abnormality in apoptosis if growth was normal

endocrine/exocrine glands
• testes degeneration starts around 3 weeks and continues past 8 weeks
• at 8 weeks, testes are about 1/4 normal weight

cellular
• epididymal sperm count averaged about 30% lower
• low levels of sperm in the epididymis at 8 weeks and that sperm was abnormal
• increased apoptosis in E9.5 and E11.5 growth arrested female embryos
• no abnormality in apoptosis if growth was normal




Genotype
MGI:2682597
hm3
Allelic
Composition
Ubr2tm1Ytkw/Ubr2tm1Ytkw
Genetic
Background
involves: 129S1/Sv * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ubr2tm1Ytkw mutation (0 available); any Ubr2 mutation (86 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• lower than expected numbers (9) of homozygous females born

reproductive system
• testes degeneration not as severe as on a mixed background with C57BL/6

endocrine/exocrine glands
• testes degeneration not as severe as on a mixed background with C57BL/6




Genotype
MGI:3663588
cx4
Allelic
Composition
Ubr1tm1Avar/Ubr1tm1Avar
Ubr2tm1Ytkw/Ubr2tm1Ytkw
Genetic
Background
involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ubr1tm1Avar mutation (0 available); any Ubr1 mutation (93 available)
Ubr2tm1Ytkw mutation (0 available); any Ubr2 mutation (86 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Abnormal development of the central nervous system in Ubr1tm1Avar/Ubr1tm1Avar Ubr2tm1Ytkw/Ubr2tm1Ytkw embryos

mortality/aging

growth/size/body
• embryos are smaller at E10.5 but not at earlier stages

embryo
• by E10.5, blood vessels in the yolk sac are thinner and less branched
• growth ceases at around E10.5
• embryos are smaller at E10.5 but not at earlier stages
• neuroepithelium at E10.5 is composed of 3 layers (VZ, SVZ, and mantle) instead of two (VZ and mantle) as in wild-type
• neuroepithelium at E10.5 is thin, with greater severity in the forebrain than in the spinal cord
• neuroepithelial structures do not increase in thickness after E10.5, in contrast to control embryos
• neural tubes are normal at E10.5 but by E11.5 become kinked
• appears pale by E10.5 but not at earlier stages
• staining for Pecam-1 at E10.5 shows that growth, remodeling, and branching of both small and large vessels is impaired

nervous system
• exhibit increased amounts apoptosis throughout the neural tubes at E10.5
• reduction in proliferation and precocious migration and differentiation of neural progenitor cells
• decrease in the levels of S-phase neural precursor cells throughout the anteroposterior axis at E10.5, indicating impaired proliferation in the ventricular zone (VZ)
• higher numbers of mitotic neural precursors are present in the VZ of the forebrain at E10.5 and the distribution of mitotic cells is disorganized
• many mitotic cells appear to be between the interphase and prophase (instead of prophase or prometaphase as in wild-type), suggesting an arrest
• neuroepithelium at E10.5 is composed of 3 layers (VZ, SVZ, and mantle) instead of two (VZ and mantle) as in wild-type
• neuroepithelium at E10.5 is thin, with greater severity in the forebrain than in the spinal cord
• neuroepithelial structures do not increase in thickness after E10.5, in contrast to control embryos
• neural tubes are normal at E10.5 but by E11.5 become kinked
• by E11.5, forebrain morphology is distorted, with serpentine, thin, often disjointed neuroepithelial layers of varying thickness

cardiovascular system
• larger vessels such as the intracranial artery are thin an poorly developed at E10.5
• by E10.5, blood vessels in the yolk sac are thinner and less branched
• exhibit a large space between the heart and pericardium at E10.5, consistent with the accumulation of pericardial fluid
• trabeculations are thinner and less abundant
• disorganization of the myocardial wall at E10.5
• development of the atria and ventricles is arrested by E10.5
• development of the atria is arrested by E10.5
• interatrial septa formation is not observed by E10.5
• development of the ventricles is arrested by E10.5
• variable levels of ventricular atrophy
• interventricular septa formation is not observed by E10.5
• seen by E10.5
• seen by E10.5
• develop local hemorrhages by E10.5 (but not at E9.5)

muscle
• trabeculations are thinner and less abundant
• disorganization of the myocardial wall at E10.5

homeostasis/metabolism
• seen by E10.5

cellular
• exhibit increased amounts apoptosis throughout the neural tubes at E10.5
• reduction in proliferation and precocious migration and differentiation of neural progenitor cells
• decrease in the levels of S-phase neural precursor cells throughout the anteroposterior axis at E10.5, indicating impaired proliferation in the ventricular zone (VZ)
• higher numbers of mitotic neural precursors are present in the VZ of the forebrain at E10.5 and the distribution of mitotic cells is disorganized
• many mitotic cells appear to be between the interphase and prophase (instead of prophase or prometaphase as in wild-type), suggesting an arrest





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/19/2024
MGI 6.23
The Jackson Laboratory