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Allele Symbol Allele Name Allele ID |
Bbc3tm1Ast targeted mutation 1, Andreas Strasser MGI:2681654 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• thymocytes and MEFs show enhanced resistance to genotoxic damage induced by etoposide or gamma irradiation
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• in thymocytes and MEFs
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• espite abnormalities in T cell survival, viral clearance is similar to controls and no abnormalities are detected in T cell activation or proliferation
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• at 2 and 4 weeks after infection with HSV-1, mice show a significant increase in total leukocyte numbers compared to controls
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• at 2 and 4 weeks after infection with HSV-1, mice show a significant increase in CD8+ T cell numbers compared to controls
• at 2 and 4 weeks after infection mice show a 2- to 4-fold increase in numbers of Kb-gB+ CD8+ T cells compared to controls
• however, CD8+ T cell numbers in nonlymphoid organs are normal
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• at 2 and 4 weeks after infection mice an increase in the percentage of Kb-gB+ CD8+ T cells compared to controls
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• HSV-1 antigen specific CD8+ T cells show enhanced survival when cultured in the absence of cytokines
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• treatment of neurons with oxidative stressors induced less apoptosis compared to controls and treated neurons retain normal voltage dependent current activity unlike controls
(J:127640)
• motor neurons show decreased sensitivity to tunicamycin but not to the glutamate agonist alpha-amino-3-hydroxy-5-methyl-4-isoxazoleprpionic acid (AMPA)
(J:130581)
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• at 2 and 4 weeks after infection with HSV-1, mice show a significant increase in total leukocyte numbers compared to controls
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• at 2 and 4 weeks after infection with HSV-1, mice show a significant increase in CD8+ T cell numbers compared to controls
• at 2 and 4 weeks after infection mice show a 2- to 4-fold increase in numbers of Kb-gB+ CD8+ T cells compared to controls
• however, CD8+ T cell numbers in nonlymphoid organs are normal
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• at 2 and 4 weeks after infection mice an increase in the percentage of Kb-gB+ CD8+ T cells compared to controls
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• HSV-1 antigen specific CD8+ T cells show enhanced survival when cultured in the absence of cytokines
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• despite the delay in disease progression, lifespan is similar to transgenic mice wild type for Bbc3
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• gliosis and microglial activation in the spinal cord at 90 days of age are reduced compared to transgenic mice wild type for Bbc3
• however, by the end stage of the disease, gliosis and microglial activation are similar to transgenic mice wild type for Bbc3
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• significant delay in motor neuron loss compared to transgenic mice wild type for Bbc3
• however, in older mice with end stage disease motor neuron loss in not different from transgenic mice wild type for Bbc3
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| N |
• unlike transgenic mice wild type for Bbc3, no decrease in stride length is seen even at 120 days of age
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• decline in paw grip endurance beginning at 98 days of age compared to 77 days of age in transgenic mice wild type for Bbc3
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• body weight begins to significantly decrease at 105 days of age compared to 77 days of age in transgenic mice wild type for Bbc3
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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