Mouse Genome Informatics
hm1
     Park2tm1Shn/Park2tm1Shn
involves: 129S4/SvJae
Key:
♀ phenotype observed in females WTSI Wellcome Trust Sanger Institute
♂ phenotype observed in males Euro Europhenome
N normal phenotype
behavior/neurological
impaired coordination ( J:86377 )
• poorer performance in various measures of motor performance
• rotarod performance was normal

nervous system
increased dopamine level ( J:86377 )
• higher than normal levels of dopamine in the striatum
abnormal nervous system electrophysiology ( J:86377 )
• higher currents are required in striatal neurons to trigger synaptic response

homeostasis/metabolism
increased dopamine level ( J:86377 )
• higher than normal levels of dopamine in the striatum

Mouse Models of Human Disease
 OMIM IDRef(s)
Parkinson Disease 2, Autosomal Recessive Juvenile; PARK2 600116 J:86377