Mouse Genome Informatics
hm1
     Il4ratm1Tch/Il4ratm1Tch
involves: 129X1/SvJ * BALB/c
Key:
♀ phenotype observed in females WTSI Wellcome Trust Sanger Institute
♂ phenotype observed in males Euro Europhenome
N normal phenotype
immune system
decreased T cell proliferation ( J:86215 )
• impaired Il-4 induced CD4+ T cell proliferation
abnormal T-helper 2 cell morphology ( J:86215 )
• decreased persistence of Th2 cells as indicated by Il-4, Il-5, and Il-13 production
• Th2 differentiation not impaired however
increased IgE level ( J:86215 )
• levels are substantially higher than normal
increased IgG level ( J:86215 )
• IgG1 and IgG2 levels are higher than normal in response to OVA stimulation
respiratory system inflammation ( J:86215 )
• airway hyperresponsiveness to methacholine
• eosinophilic infiltration
• goblet cell hyperplasia

respiratory system
respiratory system inflammation ( J:86215 )
• airway hyperresponsiveness to methacholine
• eosinophilic infiltration
• goblet cell hyperplasia
increased airway responsiveness ( J:86215 )
• with methacholine challenge

hematopoietic system
decreased T cell proliferation ( J:86215 )
• impaired Il-4 induced CD4+ T cell proliferation
abnormal T-helper 2 cell morphology ( J:86215 )
• decreased persistence of Th2 cells as indicated by Il-4, Il-5, and Il-13 production
• Th2 differentiation not impaired however

cellular
decreased T cell proliferation ( J:86215 )
• impaired Il-4 induced CD4+ T cell proliferation

Mouse Models of Human Disease
 OMIM IDRef(s)
Asthma, Susceptibility to 600807 J:86215