Mouse Genome Informatics
hm1
    Il4ratm1Tch/Il4ratm1Tch
involves: 129X1/SvJ * BALB/c
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• impaired Il-4 induced CD4+ T cell proliferation
• decreased persistence of Th2 cells as indicated by Il-4, Il-5, and Il-13 production
• Th2 differentiation not impaired however
• levels are substantially higher than normal
• IgG1 and IgG2 levels are higher than normal in response to OVA stimulation
• airway hyperresponsiveness to methacholine
• eosinophilic infiltration
• goblet cell hyperplasia

respiratory system
• airway hyperresponsiveness to methacholine
• eosinophilic infiltration
• goblet cell hyperplasia
• with methacholine challenge

hematopoietic system
• impaired Il-4 induced CD4+ T cell proliferation
• decreased persistence of Th2 cells as indicated by Il-4, Il-5, and Il-13 production
• Th2 differentiation not impaired however
• levels are substantially higher than normal
• IgG1 and IgG2 levels are higher than normal in response to OVA stimulation

Mouse Models of Human Disease
OMIM IDRef(s)
Asthma, Susceptibility to 600807 J:86215