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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Camk2a-cre)2834Lusc
transgene insertion 2834, Bernhard Luscher
MGI:2680625
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Arhgef9tm1Betz/Y
Tg(Camk2a-cre)2834Lusc/0
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3820315
cn2
Gabrg2tm2Lusc/Gabrg2tm2Lusc
Tg(Camk2a-cre)2834Lusc/0
involves: 129P2/OlaHsd * 129X1/SvJ MGI:2680627
cn3
Syngap1tm1.1Mabk/Syngap1tm1.2Mabk
Tg(Camk2a-cre)2834Lusc/0
involves: 129S1/Sv * C57BL/6 MGI:3604393
cn4
Ext1tm1Yama/Ext1tm1Yama
Tg(Camk2a-cre)2834Lusc/0
involves: 129S5/SvEvBrd * C57BL/6 MGI:5316488
cn5
Slc6a9tm1.1Bois/Slc6a9tm1.1Bois
Tg(Camk2a-cre)2834Lusc/0
involves: C57BL/6J MGI:3624966


Genotype
MGI:3820315
cn1
Allelic
Composition
Arhgef9tm1Betz/Y
Tg(Camk2a-cre)2834Lusc/0
Genetic
Background
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• reduction in gephyrin cluster density in the hippocampus at P60 and P130 but not at P40 (J:141850)
• however, clustering is unaffected in other areas of the brain (J:141850)
• reduction in gephyrin cluster density in the hippocampus at P60 and P130 but not at P40 (J:141850)
• however, clustering is unaffected in other areas of the brain (J:141850)




Genotype
MGI:2680627
cn2
Allelic
Composition
Gabrg2tm2Lusc/Gabrg2tm2Lusc
Tg(Camk2a-cre)2834Lusc/0
Genetic
Background
involves: 129P2/OlaHsd * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gabrg2tm2Lusc mutation (1 available); any Gabrg2 mutation (5 available)
Tg(Camk2a-cre)2834Lusc mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• a rapid decline in health is observed by the end of the fourth postnatal week and mice die within 3 days of overt signs of stress including reduced locomotion, round pupils, and reduced weight gain (J:86221)
• a rapid decline in health is observed by the end of the fourth postnatal week and mice die within 3 days of overt signs of stress including reduced locomotion, round pupils, and reduced weight gain (J:86221)

behavior/neurological
• lack of locomotion is observed as health declines (J:86221)
• lack of locomotion is observed as health declines (J:86221)
• some mice exhibit overt epilepsy within several days prior to death; typical seizures start with rearing adn loss of postural control, followed by running fits and violent convulsions (J:86221)
• some mice exhibit overt epilepsy within several days prior to death; typical seizures start with rearing adn loss of postural control, followed by running fits and violent convulsions (J:86221)

nervous system
• some mice exhibit overt epilepsy within several days prior to death; typical seizures start with rearing adn loss of postural control, followed by running fits and violent convulsions (J:86221)
• some mice exhibit overt epilepsy within several days prior to death; typical seizures start with rearing adn loss of postural control, followed by running fits and violent convulsions (J:86221)




Genotype
MGI:3604393
cn3
Allelic
Composition
Syngap1tm1.1Mabk/Syngap1tm1.2Mabk
Tg(Camk2a-cre)2834Lusc/0
Genetic
Background
involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Syngap1tm1.1Mabk mutation (1 available); any Syngap1 mutation (5 available)
Syngap1tm1.2Mabk mutation (1 available); any Syngap1 mutation (5 available)
Tg(Camk2a-cre)2834Lusc mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 12.6% (13 out of 103) referred to as "mini" were significantly smaller at P7 and died by 3 weeks after birth (J:101084)
• remaining mutant were phenotypically normal up to the forth postnatal week and their weight was statistically indistinguishable from controls (J:101084)
• 12.6% (13 out of 103) referred to as "mini" were significantly smaller at P7 and died by 3 weeks after birth (J:101084)
• remaining mutant were phenotypically normal up to the forth postnatal week and their weight was statistically indistinguishable from controls (J:101084)

nervous system
• many more neurons stain positively for activated caspase-3 in the brains of homozygous mice at 2 weeks and 8weeks after birth (J:101084)
• more activation of caspase-3 in the cell body layers of the hippocampus were found note: level of synGAP protein correspond to 20-25% of wild-type in ""mini"" group and 37.5% of wild-type in normal group more activation of caspase-3 in the cell body layerof the hippocampus were found note: level of synGAP protein correspond to 20-25% of wild-type in ""mini"" group and 37.5% of wild-type in normal group more activation of caspase-3 in the cell body layers of the hippocampus were found note: level of synGAProtein correspond to 20-25% of wild-type in ""mini"" group and 37.5% of wild-type in normal group more activation of caspase-3 in the cell body layers of the hippocampus were found (J:101084)
• level of synGAP protein correspond to 20-25% of wild-type in ""mini"" group and 37.5% of wild-type in normal group (J:101084)
• level of synGAP protein correlate with severity of neuronal apoptosis (J:101084)
• many more neurons stain positively for activated caspase-3 in the brains of homozygous mice at 2 weeks and 8weeks after birth (J:101084)
• more activation of caspase-3 in the cell body layers of the hippocampus were found note: level of synGAP protein correspond to 20-25% of wild-type in ""mini"" group and 37.5% of wild-type in normal group more activation of caspase-3 in the cell body layerof the hippocampus were found note: level of synGAP protein correspond to 20-25% of wild-type in ""mini"" group and 37.5% of wild-type in normal group more activation of caspase-3 in the cell body layers of the hippocampus were found note: level of synGAProtein correspond to 20-25% of wild-type in ""mini"" group and 37.5% of wild-type in normal group more activation of caspase-3 in the cell body layers of the hippocampus were found (J:101084)
• level of synGAP protein correspond to 20-25% of wild-type in ""mini"" group and 37.5% of wild-type in normal group (J:101084)
• level of synGAP protein correlate with severity of neuronal apoptosis (J:101084)

cellular
• many more neurons stain positively for activated caspase-3 in the brains of homozygous mice at 2 weeks and 8weeks after birth (J:101084)
• more activation of caspase-3 in the cell body layers of the hippocampus were found note: level of synGAP protein correspond to 20-25% of wild-type in ""mini"" group and 37.5% of wild-type in normal group more activation of caspase-3 in the cell body layerof the hippocampus were found note: level of synGAP protein correspond to 20-25% of wild-type in ""mini"" group and 37.5% of wild-type in normal group more activation of caspase-3 in the cell body layers of the hippocampus were found note: level of synGAProtein correspond to 20-25% of wild-type in ""mini"" group and 37.5% of wild-type in normal group more activation of caspase-3 in the cell body layers of the hippocampus were found (J:101084)
• level of synGAP protein correspond to 20-25% of wild-type in ""mini"" group and 37.5% of wild-type in normal group (J:101084)
• level of synGAP protein correlate with severity of neuronal apoptosis (J:101084)
• many more neurons stain positively for activated caspase-3 in the brains of homozygous mice at 2 weeks and 8weeks after birth (J:101084)
• more activation of caspase-3 in the cell body layers of the hippocampus were found note: level of synGAP protein correspond to 20-25% of wild-type in ""mini"" group and 37.5% of wild-type in normal group more activation of caspase-3 in the cell body layerof the hippocampus were found note: level of synGAP protein correspond to 20-25% of wild-type in ""mini"" group and 37.5% of wild-type in normal group more activation of caspase-3 in the cell body layers of the hippocampus were found note: level of synGAProtein correspond to 20-25% of wild-type in ""mini"" group and 37.5% of wild-type in normal group more activation of caspase-3 in the cell body layers of the hippocampus were found (J:101084)
• level of synGAP protein correspond to 20-25% of wild-type in ""mini"" group and 37.5% of wild-type in normal group (J:101084)
• level of synGAP protein correlate with severity of neuronal apoptosis (J:101084)




Genotype
MGI:5316488
cn4
Allelic
Composition
Ext1tm1Yama/Ext1tm1Yama
Tg(Camk2a-cre)2834Lusc/0
Genetic
Background
involves: 129S5/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ext1tm1Yama mutation (0 available); any Ext1 mutation (20 available)
Tg(Camk2a-cre)2834Lusc mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• in the elevated plus maze, mutants spend more than half the session time on the open arms and moved freely on them compared to wild-type mice that remain mostly on the closed arms, indicating reduced fear of height (J:182220)
• in the light/dark box text, mutants spent more time in the brightly illuminated space than wild-type mice, although the number of transitions between light and dark spaces did not differ (J:182220)
• in the open-field test, mutants spend a longer time in the central area than wild-type mice and exhibit higher levels of locomotor activity, indicating reduced fear of open spaces (J:182220)
• in the elevated plus maze, mutants spend more than half the session time on the open arms and moved freely on them compared to wild-type mice that remain mostly on the closed arms, indicating reduced fear of height (J:182220)
• in the light/dark box text, mutants spent more time in the brightly illuminated space than wild-type mice, although the number of transitions between light and dark spaces did not differ (J:182220)
• in the open-field test, mutants spend a longer time in the central area than wild-type mice and exhibit higher levels of locomotor activity, indicating reduced fear of open spaces (J:182220)
• in the elevated plus maze, mutants spend more than half the session time on the open arms and moved freely on them compared to wild-type mice that remain mostly on the closed arms, indicating reduced fear of height (J:182220)
• in the light/dark box text, mutants spent more time in the brightly illuminated space than wild-type mice, although the number of transitions between light and dark spaces did not differ (J:182220)
• in the open-field test, mutants spend a longer time in the central area than wild-type mice and exhibit higher levels of locomotor activity, indicating reduced fear of open spaces (J:182220)
• in the elevated plus maze, mutants spend more than half the session time on the open arms and moved freely on them compared to wild-type mice that remain mostly on the closed arms, indicating reduced fear of height (J:182220)
• in the light/dark box text, mutants spent more time in the brightly illuminated space than wild-type mice, although the number of transitions between light and dark spaces did not differ (J:182220)
• in the open-field test, mutants spend a longer time in the central area than wild-type mice and exhibit higher levels of locomotor activity, indicating reduced fear of open spaces (J:182220)
• in the open-field test, mutants exhibit higher levels of locomotor activity (J:182220)
• in the open-field test, mutants exhibit higher levels of locomotor activity (J:182220)
• in the hole-board test, while wild-type mice explore different holes in a random or successive manner, mutants show a tendency towards making repeated head-dips into the same hole, indicating stereotyped dip behavior; occurrence of stereotypic dip was significantly greater, however the total number of head-dips did not differ from wild-type (J:182220)
• mutants show a tendency to perform consecutive head-dips of more than 4 repetitions, a behavior not seen in wild-type mice (J:182220)
• however, mutants do not exhibit spontaneous stereotypic behavior such as jumping, circling, paw flapping or self-grooming (J:182220)
• in the hole-board test, while wild-type mice explore different holes in a random or successive manner, mutants show a tendency towards making repeated head-dips into the same hole, indicating stereotyped dip behavior; occurrence of stereotypic dip was significantly greater, however the total number of head-dips did not differ from wild-type (J:182220)
• mutants show a tendency to perform consecutive head-dips of more than 4 repetitions, a behavior not seen in wild-type mice (J:182220)
• however, mutants do not exhibit spontaneous stereotypic behavior such as jumping, circling, paw flapping or self-grooming (J:182220)
• in the hot plate test, mutants exhibit shorter latency to respond to thermal stimuli indicating sensory hypersensitivity (J:182220)
• in the hot plate test, mutants exhibit shorter latency to respond to thermal stimuli indicating sensory hypersensitivity (J:182220)
• mutants exhibit reduced nest-building activity (J:182220)
• mutants exhibit reduced nest-building activity (J:182220)
• in a separation-reunion test with siblings, mutants show less interactions with siblings after reunion (J:182220)
• in the resident-intruder test, while wild-type mice explore the intruder extensively, mutants seldom chase the intruder and instead frequently show behaviors of avoidance, such as freezing and moving away (J:182220)
• in the social dominance tube test, mutants almost always retreat out of the tube and lose (J:182220)
• in a separation-reunion test with siblings, mutants show less interactions with siblings after reunion (J:182220)
• in the resident-intruder test, while wild-type mice explore the intruder extensively, mutants seldom chase the intruder and instead frequently show behaviors of avoidance, such as freezing and moving away (J:182220)
• in the social dominance tube test, mutants almost always retreat out of the tube and lose (J:182220)
• ultrasonic vocalization emitted by mutants is reduced significantly in terms of number, duration, and amplitude of calls in response to female odor compared to wild-type mice (J:182220)
• complexity of ultrasonic vocalization is reduced compared to wild-type mice (J:182220)
• ultrasonic vocalization emitted by mutants is reduced significantly in terms of number, duration, and amplitude of calls in response to female odor compared to wild-type mice (J:182220)
• complexity of ultrasonic vocalization is reduced compared to wild-type mice (J:182220)

integument
• in the hot plate test, mutants exhibit shorter latency to respond to thermal stimuli indicating sensory hypersensitivity (J:182220)
• in the hot plate test, mutants exhibit shorter latency to respond to thermal stimuli indicating sensory hypersensitivity (J:182220)

nervous system
• excitatory synaptic transmission is altered in amygdala neurons (J:182220)
• however, mutants do not exhibit overt abnormalities in the overall morphology of the amygdala or in the morphology of dendritic arbors and spines in pyramidal neurons of the basolateral amygdala (J:182220)
• excitatory synaptic transmission is altered in amygdala neurons (J:182220)
• however, mutants do not exhibit overt abnormalities in the overall morphology of the amygdala or in the morphology of dendritic arbors and spines in pyramidal neurons of the basolateral amygdala (J:182220)
• mutants exhibit depressed input-output curve of compound excitatory postsynaptic currents (EPSCs) in the basolateral amygdala (J:182220)
• mutants exhibit depressed input-output curve of compound excitatory postsynaptic currents (EPSCs) in the basolateral amygdala (J:182220)
• mutants exhibit reduced AMPA receptor-mediated synaptic strength in basolateral amygdala neurons (J:182220)
• mutants exhibit reduced AMPA receptor-mediated synaptic strength in basolateral amygdala neurons (J:182220)
• frequency of mEPSCs is reduced in mutant basolateral amygdala pyramidal neurons (J:182220)
• amplitude of mEPSCs is reduced in basolateral amygdala neurons, indicating that AMPA receptor-mediated postsynaptic activity is reduced (J:182220)
• however, neither the rising nor the decay of time of mEPSCs is altered, indicating that channel kinetics of AMPA receptors is preserved (J:182220)
• frequency of mEPSCs is reduced in mutant basolateral amygdala pyramidal neurons (J:182220)
• amplitude of mEPSCs is reduced in basolateral amygdala neurons, indicating that AMPA receptor-mediated postsynaptic activity is reduced (J:182220)
• however, neither the rising nor the decay of time of mEPSCs is altered, indicating that channel kinetics of AMPA receptors is preserved (J:182220)

Mouse Models of Human Disease
OMIM ID Ref(s)
Autism 209850 J:180302




Genotype
MGI:3624966
cn5
Allelic
Composition
Slc6a9tm1.1Bois/Slc6a9tm1.1Bois
Tg(Camk2a-cre)2834Lusc/0
Genetic
Background
involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc6a9tm1.1Bois mutation (0 available); any Slc6a9 mutation (2 available)
Tg(Camk2a-cre)2834Lusc mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mutants exhibit reduced sensitivity to the motor stimulant effect of amphetamine and phencyclidine compared to control mice; the effect of amphetamine is delayed in the mutant while the response to phencyclidine is strongly attenuated compared to control (J:106967)
• mutants exhibit reduced sensitivity to the motor stimulant effect of amphetamine and phencyclidine compared to control mice; the effect of amphetamine is delayed in the mutant while the response to phencyclidine is strongly attenuated compared to control (J:106967)
• mutant mice show enhanced acquisition of active avoidance with an augmented latent inhibition effect in the testing paradigm used (J:106967)
• mutant mice show enhanced acquisition of active avoidance with an augmented latent inhibition effect in the testing paradigm used (J:106967)
• mutants show enhanced expression of conditioned taste-aversion with an augmented latent inhibition effect in the testing paradigm used (J:106967)
• mutants show enhanced expression of conditioned taste-aversion with an augmented latent inhibition effect in the testing paradigm used (J:106967)
• mutants exhibit and ehanced expression of conditioned tone-freezing with an augemented latent inhibition effect in the testing paradigm used (J:106967)
• mutants exhibit and ehanced expression of conditioned tone-freezing with an augemented latent inhibition effect in the testing paradigm used (J:106967)
• augmented latent inhibition in conditioned freezing, conditioned active avoidance, and conditioned taste aversion tests (J:106967)
• augmented latent inhibition in conditioned freezing, conditioned active avoidance, and conditioned taste aversion tests (J:106967)

nervous system
• in conditional mutants at P21-30, a 2.15-fold enhancement of the NMDA/AMPA response ratio compared to control is measured in brain slices (J:106967)
• in conditional mutants at P21-30, a 2.15-fold enhancement of the NMDA/AMPA response ratio compared to control is measured in brain slices (J:106967)





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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory