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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Camk2a-cre)2834Lusc
transgene insertion 2834, Bernhard Luscher
MGI:2680625
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Arhgef9tm1Betz/Y
Tg(Camk2a-cre)2834Lusc/0
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3820315
cn2
Gabrg2tm2Lusc/Gabrg2tm2Lusc
Tg(Camk2a-cre)2834Lusc/0
involves: 129P2/OlaHsd * 129X1/SvJ MGI:2680627
cn3
Syngap1tm1.1Mabk/Syngap1tm1.2Mabk
Tg(Camk2a-cre)2834Lusc/0
involves: 129S1/Sv * C57BL/6 MGI:3604393
cn4
Ext1tm1Yama/Ext1tm1Yama
Tg(Camk2a-cre)2834Lusc/0
involves: 129S5/SvEvBrd * C57BL/6 MGI:5316488
cn5
Slc6a9tm1.1Bois/Slc6a9tm1.1Bois
Tg(Camk2a-cre)2834Lusc/0
involves: C57BL/6J MGI:3624966


Genotype
MGI:3820315
cn1
Allelic
Composition
Arhgef9tm1Betz/Y
Tg(Camk2a-cre)2834Lusc/0
Genetic
Background
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arhgef9tm1Betz mutation (0 available); any Arhgef9 mutation (4 available)
Tg(Camk2a-cre)2834Lusc mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• reduction in gephyrin cluster density in the hippocampus at P60 and P130 but not at P40
• however, clustering is unaffected in other areas of the brain




Genotype
MGI:2680627
cn2
Allelic
Composition
Gabrg2tm2Lusc/Gabrg2tm2Lusc
Tg(Camk2a-cre)2834Lusc/0
Genetic
Background
involves: 129P2/OlaHsd * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gabrg2tm2Lusc mutation (1 available); any Gabrg2 mutation (12 available)
Tg(Camk2a-cre)2834Lusc mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• a rapid decline in health is observed by the end of the fourth postnatal week and mice die within 3 days of overt signs of stress including reduced locomotion, round pupils, and reduced weight gain

behavior/neurological
• lack of locomotion is observed as health declines
• some mice exhibit overt epilepsy within several days prior to death; typical seizures start with rearing adn loss of postural control, followed by running fits and violent convulsions

nervous system
• some mice exhibit overt epilepsy within several days prior to death; typical seizures start with rearing adn loss of postural control, followed by running fits and violent convulsions




Genotype
MGI:3604393
cn3
Allelic
Composition
Syngap1tm1.1Mabk/Syngap1tm1.2Mabk
Tg(Camk2a-cre)2834Lusc/0
Genetic
Background
involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Syngap1tm1.1Mabk mutation (1 available); any Syngap1 mutation (20 available)
Syngap1tm1.2Mabk mutation (1 available); any Syngap1 mutation (20 available)
Tg(Camk2a-cre)2834Lusc mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 12.6% (13 out of 103) referred to as "mini" were significantly smaller at P7 and died by 3 weeks after birth
• remaining mutant were phenotypically normal up to the forth postnatal week and their weight was statistically indistinguishable from controls

nervous system
• many more neurons stain positively for activated caspase-3 in the brains of homozygous mice at 2 weeks and 8weeks after birth
• more activation of caspase-3 in the cell body layers of the hippocampus were found note: level of synGAP protein correspond to 20-25% of wild-type in ""mini"" group and 37.5% of wild-type in normal group more activation of caspase-3 in the cell body layerof the hippocampus were found note: level of synGAP protein correspond to 20-25% of wild-type in ""mini"" group and 37.5% of wild-type in normal group more activation of caspase-3 in the cell body layers of the hippocampus were found note: level of synGAProtein correspond to 20-25% of wild-type in ""mini"" group and 37.5% of wild-type in normal group more activation of caspase-3 in the cell body layers of the hippocampus were found
• level of synGAP protein correspond to 20-25% of wild-type in ""mini"" group and 37.5% of wild-type in normal group
• level of synGAP protein correlate with severity of neuronal apoptosis

cellular
• many more neurons stain positively for activated caspase-3 in the brains of homozygous mice at 2 weeks and 8weeks after birth
• more activation of caspase-3 in the cell body layers of the hippocampus were found note: level of synGAP protein correspond to 20-25% of wild-type in ""mini"" group and 37.5% of wild-type in normal group more activation of caspase-3 in the cell body layerof the hippocampus were found note: level of synGAP protein correspond to 20-25% of wild-type in ""mini"" group and 37.5% of wild-type in normal group more activation of caspase-3 in the cell body layers of the hippocampus were found note: level of synGAProtein correspond to 20-25% of wild-type in ""mini"" group and 37.5% of wild-type in normal group more activation of caspase-3 in the cell body layers of the hippocampus were found
• level of synGAP protein correspond to 20-25% of wild-type in ""mini"" group and 37.5% of wild-type in normal group
• level of synGAP protein correlate with severity of neuronal apoptosis




Genotype
MGI:5316488
cn4
Allelic
Composition
Ext1tm1Yama/Ext1tm1Yama
Tg(Camk2a-cre)2834Lusc/0
Genetic
Background
involves: 129S5/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ext1tm1Yama mutation (0 available); any Ext1 mutation (33 available)
Tg(Camk2a-cre)2834Lusc mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• in the elevated plus maze, mutants spend more than half the session time on the open arms and moved freely on them compared to wild-type mice that remain mostly on the closed arms, indicating reduced fear of height
• in the light/dark box text, mutants spent more time in the brightly illuminated space than wild-type mice, although the number of transitions between light and dark spaces did not differ
• in the open-field test, mutants spend a longer time in the central area than wild-type mice and exhibit higher levels of locomotor activity, indicating reduced fear of open spaces
• in the elevated plus maze, mutants spend more than half the session time on the open arms and moved freely on them compared to wild-type mice that remain mostly on the closed arms, indicating reduced fear of height
• in the light/dark box text, mutants spent more time in the brightly illuminated space than wild-type mice, although the number of transitions between light and dark spaces did not differ
• in the open-field test, mutants spend a longer time in the central area than wild-type mice and exhibit higher levels of locomotor activity, indicating reduced fear of open spaces
• in the open-field test, mutants exhibit higher levels of locomotor activity
• in the hole-board test, while wild-type mice explore different holes in a random or successive manner, mutants show a tendency towards making repeated head-dips into the same hole, indicating stereotyped dip behavior; occurrence of stereotypic dip was significantly greater, however the total number of head-dips did not differ from wild-type
• mutants show a tendency to perform consecutive head-dips of more than 4 repetitions, a behavior not seen in wild-type mice
• however, mutants do not exhibit spontaneous stereotypic behavior such as jumping, circling, paw flapping or self-grooming
• in the hot plate test, mutants exhibit shorter latency to respond to thermal stimuli indicating sensory hypersensitivity
• mutants exhibit reduced nest-building activity
• in a separation-reunion test with siblings, mutants show less interactions with siblings after reunion
• in the resident-intruder test, while wild-type mice explore the intruder extensively, mutants seldom chase the intruder and instead frequently show behaviors of avoidance, such as freezing and moving away
• in the social dominance tube test, mutants almost always retreat out of the tube and lose
• ultrasonic vocalization emitted by mutants is reduced significantly in terms of number, duration, and amplitude of calls in response to female odor compared to wild-type mice
• complexity of ultrasonic vocalization is reduced compared to wild-type mice

integument
• in the hot plate test, mutants exhibit shorter latency to respond to thermal stimuli indicating sensory hypersensitivity

nervous system
• excitatory synaptic transmission is altered in amygdala neurons
• however, mutants do not exhibit overt abnormalities in the overall morphology of the amygdala or in the morphology of dendritic arbors and spines in pyramidal neurons of the basolateral amygdala
• mutants exhibit depressed input-output curve of compound excitatory postsynaptic currents (EPSCs) in the basolateral amygdala
• mutants exhibit reduced AMPA receptor-mediated synaptic strength in basolateral amygdala neurons
• frequency of mEPSCs is reduced in mutant basolateral amygdala pyramidal neurons
• amplitude of mEPSCs is reduced in basolateral amygdala neurons, indicating that AMPA receptor-mediated postsynaptic activity is reduced
• however, neither the rising nor the decay of time of mEPSCs is altered, indicating that channel kinetics of AMPA receptors is preserved

Mouse Models of Human Disease
OMIM ID Ref(s)
Autism 209850 J:182220




Genotype
MGI:3624966
cn5
Allelic
Composition
Slc6a9tm1.1Bois/Slc6a9tm1.1Bois
Tg(Camk2a-cre)2834Lusc/0
Genetic
Background
involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc6a9tm1.1Bois mutation (0 available); any Slc6a9 mutation (7 available)
Tg(Camk2a-cre)2834Lusc mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mutants exhibit reduced sensitivity to the motor stimulant effect of amphetamine and phencyclidine compared to control mice; the effect of amphetamine is delayed in the mutant while the response to phencyclidine is strongly attenuated compared to control
• mutant mice show enhanced acquisition of active avoidance with an augmented latent inhibition effect in the testing paradigm used
• mutants show enhanced expression of conditioned taste-aversion with an augmented latent inhibition effect in the testing paradigm used
• mutants exhibit and ehanced expression of conditioned tone-freezing with an augemented latent inhibition effect in the testing paradigm used
• augmented latent inhibition in conditioned freezing, conditioned active avoidance, and conditioned taste aversion tests

nervous system
• in conditional mutants at P21-30, a 2.15-fold enhancement of the NMDA/AMPA response ratio compared to control is measured in brain slices





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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory