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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Gabrg2tm2Lusc
targeted mutation 2, Bernhard Luscher
MGI:2680624
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Gabrg2tm2Lusc/Gabrg2tm2Lusc involves: 129P2/OlaHsd * 129X1/SvJ MGI:2680628
cn2
Gabrg2tm2Lusc/Gabrg2tm2Lusc
Tg(Camk2a-cre)2834Lusc/0
involves: 129P2/OlaHsd * 129X1/SvJ MGI:2680627
cn3
Gabrg2tm2Lusc/Gabrg2tm2Lusc
Tg(Camk2a-cre)T50Stl/0
involves: 129X1/SvJ * BALB/c * C57BL/6 MGI:2680635


Genotype
MGI:2680628
hm1
Allelic
Composition
Gabrg2tm2Lusc/Gabrg2tm2Lusc
Genetic
Background
involves: 129P2/OlaHsd * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gabrg2tm2Lusc mutation (1 available); any Gabrg2 mutation (41 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype




Genotype
MGI:2680627
cn2
Allelic
Composition
Gabrg2tm2Lusc/Gabrg2tm2Lusc
Tg(Camk2a-cre)2834Lusc/0
Genetic
Background
involves: 129P2/OlaHsd * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gabrg2tm2Lusc mutation (1 available); any Gabrg2 mutation (41 available)
Tg(Camk2a-cre)2834Lusc mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• a rapid decline in health is observed by the end of the fourth postnatal week and mice die within 3 days of overt signs of stress including reduced locomotion, round pupils, and reduced weight gain

behavior/neurological
• lack of locomotion is observed as health declines
• some mice exhibit overt epilepsy within several days prior to death; typical seizures start with rearing adn loss of postural control, followed by running fits and violent convulsions

nervous system
• some mice exhibit overt epilepsy within several days prior to death; typical seizures start with rearing adn loss of postural control, followed by running fits and violent convulsions




Genotype
MGI:2680635
cn3
Allelic
Composition
Gabrg2tm2Lusc/Gabrg2tm2Lusc
Tg(Camk2a-cre)T50Stl/0
Genetic
Background
involves: 129X1/SvJ * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gabrg2tm2Lusc mutation (1 available); any Gabrg2 mutation (41 available)
Tg(Camk2a-cre)T50Stl mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die around 7 weeks of age





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory