All Phenotypes Erbb4<tm1Fej> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Erbb4^tm1Fej
targeted mutation 1, Frank E Jones
MGI:2680217

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Erbb4^tm1Fej/Erbb4^tm1Fej Pvalb^tm1(cre)Arbr/Pvalb⁺	involves: 129 * C57BL/6	MGI:5318191
cn2	Erbb3^tm2Cbm/Erbb3^tm3Cbm Erbb4^tm1Fej/Erbb4^tm1Fej Cnp^tm1(cre)Kan/?	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ	MGI:3835562
cn3	Erbb4^tm1Fej/Erbb4^tm1Fej Tg(Wap-cre)11738Mam/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:2680269
cn4	Erbb2^tm1Mll/Erbb2^tm1Mll Erbb4^tm1Fej/Erbb4^tm1Fej Tg(Gabra6-cre)CWwis/?	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA	MGI:3836815

Allelic Composition	Erbb4^tm1Fej/Erbb4^tm1Fej Pvalb^tm1(cre)Arbr/Pvalb⁺
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Erbb4^tm1Fej mutation (1 available); any Erbb4 mutation (87 available)
Pvalb^tm1(cre)Arbr mutation (5 available); any Pvalb mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:182690 )

N	• neither cued nor contextual fear conditioning are different from controls

increased locomotor activity ( J:182690 )

• animals exhibit significantly more locomoter activity than controls in open field test

nervous system

enhanced long-term potentiation ( J:182690 )

• significantly increased compared to controls (EPSC amplitude 322% vs 157%)

decreased prepulse inhibition ( J:182690 )

• animals display deficit in PPI; reductions in PPI are more pronounced at lower prepulse sound levels than in controls

• responses are similar to Erbb4^-/- mice

Allelic Composition	Erbb3^tm2Cbm/Erbb3^tm3Cbm Erbb4^tm1Fej/Erbb4^tm1Fej Cnp^tm1(cre)Kan/?
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cnp^tm1(cre)Kan mutation (0 available); any Cnp mutation (26 available)
Erbb3^tm2Cbm mutation (0 available); any Erbb3 mutation (47 available)
Erbb3^tm3Cbm mutation (0 available); any Erbb3 mutation (47 available)
Erbb4^tm1Fej mutation (1 available); any Erbb4 mutation (87 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:145464 )

• develop to term but die in the second post natal week

nervous system

nervous system phenotype ( J:145464 )

N	• central nervous system myelination is normal up to 11 days of age (optic nerve and corpus callosum)

abnormal myelination ( J:145464 )

• severely defective myelination in the peripheral nervous system

Allelic Composition	Erbb4^tm1Fej/Erbb4^tm1Fej Tg(Wap-cre)11738Mam/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Erbb4^tm1Fej mutation (1 available); any Erbb4 mutation (87 available)
Tg(Wap-cre)11738Mam mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal mammary gland development ( J:86319 )

• lobuloalveolar development retarded

abnormal mammary gland growth during lactation ( J:86319 )

• by day 3 of lactation, extensive regression occuring, complete by day 10

• epithelial proliferation declines in first day of lactation

• early development of alveolar secretory epithelium normal, terminal stages fail

abnormal lactation ( J:86319 )

• 83% of litters born to biparous mothers die within 2 days of birth but survive when cross fostered to normal mothers

• failure of activated STAT5 to localize to nucleus

• STAT5 lacks detectable tyrosine phosphorylation

• STAT5 dependent proteins reduced

integument

abnormal mammary gland development ( J:86319 )

• lobuloalveolar development retarded

abnormal mammary gland growth during lactation ( J:86319 )

• by day 3 of lactation, extensive regression occuring, complete by day 10

• epithelial proliferation declines in first day of lactation

• early development of alveolar secretory epithelium normal, terminal stages fail

abnormal lactation ( J:86319 )

• 83% of litters born to biparous mothers die within 2 days of birth but survive when cross fostered to normal mothers

• failure of activated STAT5 to localize to nucleus

• STAT5 lacks detectable tyrosine phosphorylation

• STAT5 dependent proteins reduced

Allelic Composition	Erbb2^tm1Mll/Erbb2^tm1Mll Erbb4^tm1Fej/Erbb4^tm1Fej Tg(Gabra6-cre)CWwis/?
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Erbb2^tm1Mll mutation (1 available); any Erbb2 mutation (59 available)
Erbb4^tm1Fej mutation (1 available); any Erbb4 mutation (87 available)
Tg(Gabra6-cre)CWwis mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:145947 )

N	• no gross morphological defects in the cerebellum at 4 months • multiple climbing fiber innervation of Purkinje cells does not persist

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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