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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Ins2-HA)165Bri
transgene insertion 165, Ralph Brinster
MGI:2680173
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Fastm1Vbo/Fastm1Vbo
Tg(Ins2-cre)25Mgn/0
Tg(Ins2-HA)165Bri/0
Tg(Tcra/Tcrb)1Vbo/0
Not Specified MGI:2680187
cx2
Tg(Ins2-HA)165Bri/?
Tg(TcraCl4,TcrbCl4)1Shrm/?
involves: BALB/c * C57BL/6 * C57BL/10 MGI:3789209
cx3
Tg(Ins2-HA)165Bri/0
Tg(TcraCl4,TcrbCl4)1Shrm/0
involves: BALB/c * C57BL/6 * C57BL/10 * DBA/2 MGI:3622322
tg4
Tg(Ins2-HA)165Bri/0 B10.Cg- H2d Tg(Ins2-HA)165Bri/ShrmJ MGI:3845198


Genotype
MGI:2680187
cn1
Allelic
Composition
Fastm1Vbo/Fastm1Vbo
Tg(Ins2-cre)25Mgn/0
Tg(Ins2-HA)165Bri/0
Tg(Tcra/Tcrb)1Vbo/0
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fastm1Vbo mutation (0 available); any Fas mutation (54 available)
Tg(Ins2-cre)25Mgn mutation (2 available)
Tg(Ins2-HA)165Bri mutation (3 available)
Tg(Tcra/Tcrb)1Vbo mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• autoimmune diabetes developed with accelerated kinetics

Mouse Models of Human Disease
OMIM ID Ref(s)
Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:85985




Genotype
MGI:3789209
cx2
Allelic
Composition
Tg(Ins2-HA)165Bri/?
Tg(TcraCl4,TcrbCl4)1Shrm/?
Genetic
Background
involves: BALB/c * C57BL/6 * C57BL/10
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Ins2-HA)165Bri mutation (3 available)
Tg(TcraCl4,TcrbCl4)1Shrm mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• neonates die within 7 to 10 days of birth due to complications in glucose metabolism

homeostasis/metabolism
• one day old mice exhibit hyperglycemia with blood glucose levels averaging over 400 mg/dl
• neonates die within 7 to 10 days of birth due to complications in glucose metabolism

endocrine/exocrine glands
• pancreas of 1-day old mice are infiltrated by transgenic CD8 T cells
• the presence of infiltrating cells disrupts the normal pancreatic architecture with loss of islet mass and dissemination of the remaining islet beta cell clusters

immune system
• pancreas of 1-day old mice are infiltrated by transgenic CD8 T cells
• the presence of infiltrating cells disrupts the normal pancreatic architecture with loss of islet mass and dissemination of the remaining islet beta cell clusters




Genotype
MGI:3622322
cx3
Allelic
Composition
Tg(Ins2-HA)165Bri/0
Tg(TcraCl4,TcrbCl4)1Shrm/0
Genetic
Background
involves: BALB/c * C57BL/6 * C57BL/10 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Ins2-HA)165Bri mutation (3 available)
Tg(TcraCl4,TcrbCl4)1Shrm mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• neonates die within 7-10 days of birth

homeostasis/metabolism
• neonates exhibit hyperglycemia

endocrine/exocrine glands
• animals display a loss of islet mass and dissemination of remaining islet beta-cell clusters
• In 1-day-old animals, there are many infiltrating cells in the islet and peri-islet regions

immune system
• In 1-day-old animals, there are many infiltrating cells in the islet and peri-islet regions




Genotype
MGI:3845198
tg4
Allelic
Composition
Tg(Ins2-HA)165Bri/0
Genetic
Background
B10.Cg- H2d Tg(Ins2-HA)165Bri/ShrmJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Ins2-HA)165Bri mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• mice exhibit no evidence of autoimmunity
• mice exhibit decreased HA-specific response compared with wild-type mice
• however, mice that are irradiated and transplanted with wild-type lymphocyte mount a CD4+ T cells response to HA
• following priming with HA peptides

endocrine/exocrine glands
N
• islet beta cells exhibit normal morphology

hematopoietic system
• mice exhibit decreased HA-specific response compared with wild-type mice
• however, mice that are irradiated and transplanted with wild-type lymphocyte mount a CD4+ T cells response to HA
• following priming with HA peptides





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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory