Mouse Genome Informatics
cn1
    Fastm1Vbo/Fastm1Vbo
Tg(Ins2-cre)25Mgn/0
Tg(Ins2-HA)165Bri/0
Tg(Tcra/Tcrb)1Vbo/0

Not Specified
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• autoimmune diabetes developed with accelerated kinetics

Mouse Models of Human Disease
OMIM IDRef(s)
Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:85985


Mouse Genome Informatics
cx2
    Tg(Ins2-HA)165Bri/?
Tg(TcraCl4,TcrbCl4)1Shrm/?

involves: BALB/c * C57BL/6 * C57BL/10
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• neonates die within 7 to 10 days of birth due to complications in glucose metabolism

homeostasis/metabolism
• neonates die within 7 to 10 days of birth due to complications in glucose metabolism
• one day old mice exhibit hyperglycemia with blood glucose levels averaging over 400 mg/dl

endocrine/exocrine glands
• pancreas of 1-day old mice are infiltrated by transgenic CD8 T cells
• the presence of infiltrating cells disrupts the normal pancreatic architecture with loss of islet mass and dissemination of the remaining islet beta cell clusters

immune system
• pancreas of 1-day old mice are infiltrated by transgenic CD8 T cells
• the presence of infiltrating cells disrupts the normal pancreatic architecture with loss of islet mass and dissemination of the remaining islet beta cell clusters


Mouse Genome Informatics
cx3
    Tg(Ins2-HA)165Bri/0
Tg(TcraCl4,TcrbCl4)1Shrm/0

involves: BALB/c * C57BL/6 * C57BL/10 * DBA/2
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• neonates die within 7-10 days of birth

homeostasis/metabolism
• neonates exhibit hyperglycemia

endocrine/exocrine glands
• animals display a loss of islet mass and dissemination of remaining islet beta-cell clusters
• In 1-day-old animals, there are many infiltrating cells in the islet and peri-islet regions

immune system
• In 1-day-old animals, there are many infiltrating cells in the islet and peri-islet regions


Mouse Genome Informatics
tg4
    Tg(Ins2-HA)165Bri/0
B10.Cg- H2d Tg(Ins2-HA)165Bri/ShrmJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
N
• mice exhibit no evidence of autoimmunity (J:86430)
• following priming with HA peptides
• mice exhibit decreased HA-specific response compared with wild-type mice
• however, mice that are irradiated and transplanted with wild-type lymphocyte mount a CD4+ T cells response to HA

endocrine/exocrine glands
N
• islet beta cells exhibit normal morphology (J:86430)

hematopoietic system
• following priming with HA peptides
• mice exhibit decreased HA-specific response compared with wild-type mice
• however, mice that are irradiated and transplanted with wild-type lymphocyte mount a CD4+ T cells response to HA