All Phenotypes Cd44<tm1.1Ugu> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Cd44^tm1.1Ugu
targeted mutation 1.1, Ursula Gunthert
MGI:2679706

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cd44^tm1.1Ugu/Cd44^tm1.1Ugu	B6.129(Cg)-Cd44^tm1.1Ugu	MGI:5523443
hm2	Cd44^tm1.1Ugu/Cd44^tm1.1Ugu	involves: 129/Sv * C57BL/6	MGI:2679730
hm3	Cd44^tm1.1Ugu/Cd44^tm1.1Ugu	SJL.129(Cg)-Cd44^tm1.1Ugu	MGI:5523444
cx4	Cd44^tm1.1Ugu/Cd44^tm1.1Ugu Il10^tm1Cgn/Il10^tm1Cgn	involves: 129/Sv * C57BL/6	MGI:2679731

Allelic Composition	Cd44^tm1.1Ugu/Cd44^tm1.1Ugu
Genetic Background	B6.129(Cg)-Cd44^tm1.1Ugu

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd44^tm1.1Ugu mutation (9 available); any Cd44 mutation (67 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:199279 )

• with reduced symptoms, fewer inflammatory infiltrates and increased apoptotic activity

Allelic Composition	Cd44^tm1.1Ugu/Cd44^tm1.1Ugu
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd44^tm1.1Ugu mutation (9 available); any Cd44 mutation (67 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

abnormal digestive system physiology ( J:62867 )

• 3-4X increase of apoptotic cells in colons after injury but not without injury

immune system

immune system phenotype ( J:62867 )

N	• 78% as opposed to 44% of mice survived acute colon injury and did not develop colitis

abnormal T-helper 1 physiology ( J:62867 )

• Th1-type cytokines down regulated

abnormal T-helper 2 physiology ( J:62867 )

• Th2-type cytokines up regulated

hematopoietic system

abnormal T-helper 1 physiology ( J:62867 )

• Th1-type cytokines down regulated

abnormal T-helper 2 physiology ( J:62867 )

• Th2-type cytokines up regulated

Allelic Composition	Cd44^tm1.1Ugu/Cd44^tm1.1Ugu
Genetic Background	SJL.129(Cg)-Cd44^tm1.1Ugu

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd44^tm1.1Ugu mutation (9 available); any Cd44 mutation (67 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased T cell proliferation ( J:199279 )

• of lymph node T cells repeatedly stimulated with PLP139-151

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:199279 )

• delayed onset with reduced symptoms, fewer inflammatory infiltrates and increased apoptotic activity

hematopoietic system

decreased T cell proliferation ( J:199279 )

• of lymph node T cells repeatedly stimulated with PLP139-151

cellular

decreased T cell proliferation ( J:199279 )

• of lymph node T cells repeatedly stimulated with PLP139-151

Allelic Composition	Cd44^tm1.1Ugu/Cd44^tm1.1Ugu Il10^tm1Cgn/Il10^tm1Cgn
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd44^tm1.1Ugu mutation (9 available); any Cd44 mutation (67 available)
Il10^tm1Cgn mutation (15 available); any Il10 mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

weight loss ( J:62867 )

• normal until 24 weeks of age when they start losing weight

• life span normal in spite of weight loss

immune system

abnormal immune system physiology ( J:62867 )

• only small areas of inflammation in the mucosa

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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