Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cplx2tm1Bros mutation
(0 available);
any
Cplx2 mutation
(17 available)
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behavior/neurological
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N |
• independent of parietal cortical neurotrauma, mice exhibit normal social interaction, sucrose preference test for anhedonia, forced alternation in a T-maze, novel object recognition, and pre-pulse inhibition
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• in a Morris water maze, independent of parietal cortical neurotrauma
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• in a Morris water maze, mice subjected to parietal cortical neurotrauma exhibit increased latency to escape by trial 6 through 8 compared with similarly treated wild-type mice
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• independent of parietal cortical neurotrauma, mice spend less time in the center and intermediate area with increased time in the periphery of an open field compared with similarly treated wild-type mice
• however, mice exhibit normal anxiety-related behaviors in an elevated plus maze
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• following parietal cortical neurotrauma
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• in mice subjected to parietal cortical neurotrauma
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• on a rotarod, independent of parietal cortical neurotrauma
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• in an open field, independent of parietal cortical neurotrauma
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• MK-801-treated mice subjected to parietal cortical neurotrauma exhibit increased hyperlocomotion compared with similarly treated wild-type mice
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nervous system
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• reduced volume following parietal cortical neurotrauma
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cplx2tm1Bros mutation
(0 available);
any
Cplx2 mutation
(17 available)
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behavior/neurological
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• reduced exploration in new environment
• less active in open field
• initial higher latency to reach periphery but normal after the first day
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• slower at 8 weeks in the Morris water maze but successful in acquisition and learning new positions, much slower at 1 year
• generally poor in acquisition learning and very poor in reversal learning
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• impaired visual cliff avoidance test, more likely to approach the "cliff" and spend more time there
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• keep whiskers for longer period of time
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• rotarod performance decreases with time, initially normal, poor at 24 weeks
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• pelvis held lower than normal
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• one third of mice move backward rather than forward when placed in a new environment
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• tend not to walk in a straight line, follow a weaving path
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• less rearing activity
• fewer attempts to climb out of cages although strength is normal by hang wire test
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cplx1tm2Bros mutation
(0 available);
any
Cplx1 mutation
(13 available)
Cplx2tm1Bros mutation
(0 available);
any
Cplx2 mutation
(17 available)
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mortality/aging
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• die within a few hours of birth
(J:86365)
• mice die within a few hours of birth
(J:136393)
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nervous system
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• the amplitude of spontaneous excitatory postsynaptic currents are decreased in pre-Botzinger complex neurons compared to in wild-type mice
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• neuron calcium sensitivity of glutamate and GABA release is reduced compared to in wild-type mice
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• trains of action potentials produce a marked initial facilitation compared to the depression observed in wild-type mice
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• defect coupling action potential to presynaptic release
• hippocampal EPSC amplitudes reduced 66% but increases with trains of stimuli
• affect is on fast synchronous release
• much less of neurotransmitter released
• decreased Ca+2 sensitivity
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• evoked and spontaneous excitatory postsynaptic current amplitudes in hippocampal neurons are reduced compared to in wild-type mice
• the amplitude of spontaneous excitatory postsynaptic currents are decreased in pre-Botzinger complex neurons compared to in wild-type mice
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• mice exhibit a reduced evoked inhibitory postsynaptic currents and slightly reduced miniature inhibitory postsynaptic currents compared to wild-type mice
• spontaneous miniature inhibitory postsynaptic current frequencies are decreased in hippocampal and pre-Botzinger complex neurons compared to in wild-type mice
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• evoked miniature excitatory postsynaptic currents (mEPSCs) are slightly reduced while spontaneous mEPSCs are reduced 30% compared to in wild-type mice
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• spontaneous mEPSC frequencies are decreased in hippocampal neurons and pre-Botzinger complex neurons compared to in wild-type mice
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• the probability of vesicular release of the readily releasable pool is reduced 50% compared to in wild-type mice
• neuron calcium sensitivity of glutamate and GABA release is reduced compared to in wild-type mice
• however, the size of the readily releasable pool is normal
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cplx1tm2Bros mutation
(0 available);
any
Cplx1 mutation
(13 available)
Cplx2tm1Bros mutation
(0 available);
any
Cplx2 mutation
(17 available)
Cplx3tm1Bros mutation
(0 available);
any
Cplx3 mutation
(7 available)
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mortality/aging
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• mice die within a few hours of birth
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nervous system
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• the amplitude and frequency of spontaneous excitatory postsynaptic currents are decreased in pre-Botzinger complex neurons compared to in wild-type mice
• spontaneous mEPSC frequencies are decreased in hippocampal neurons and pre-Botzinger complex neurons compared to in wild-type
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• neuron calcium sensitivity of glutamate and GABA release is reduced compared to in wild-type mice
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• trains of action potentials produce a marked initial facilitation compared to a the depression observed in wild-type mice
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• evoked and spontaneous excitatory postsynaptic current amplitudes in hippocampal neurons are reduced compared to in wild-type mice
• in pre-Botzinger complex neurons compared to in wild-type mice
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• in pre-Botzinger complex neurons compared to in wild-type mice
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• mice exhibit a reduced evoked inhibitory postsynaptic currents and slightly reduced miniature inhibitory postsynaptic currents compared to wild-type mice
• spontaneous miniature inhibitory postsynaptic current frequencies are decreased in hippocampal and pre-Botzinger complex neurons compared to in wild-type mice
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• evoked miniature excitatory postsynaptic currents (mEPSCs) are slightly reduced while spontaneous mEPSCs are reduced 30% compared to in wild-type mice
• spontaneous mEPSC frequencies are decreased in hippocampal neurons and pre-Botzinger complex neurons compared to in wild-type mice
• the amplitude of spontaneous mEPSC in hippocampal neurons is decreased compared to in wild-type mice
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• the probability of vesicular release of the readily releasable pool is reduced 50% compared to in wild-type mice
• neuron calcium sensitivity of glutamate and GABA release is reduced compared to in wild-type mice
• however, the size of the readily releasable pool is normal
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cplx2tm1Bros mutation
(0 available);
any
Cplx2 mutation
(17 available)
Cplx3tm1Bros mutation
(0 available);
any
Cplx3 mutation
(7 available)
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mortality/aging
nervous system
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N |
• action potential-evoked excitatory and inhibitory postsynaptic currents are normal
• despite alterations in synaptic transmission, readily releasable pools are normal
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reproductive system
Analysis Tools