Phenotypes associated with this allele

• Allele Symbol: Fos^tm7Wag
• Allele Name: targeted mutation 7, Erwin F Wagner
• Allele ID: MGI:2679338
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fos^tm7Wag/Fos^tm7Wag	involves: 129P2/OlaHsd	MGI:2679377
cn2	Fos^tm7Wag/Fos^tm7Wag Tg(Nes-cre)1Kln/?	involves: 129P2/OlaHsd	MGI:2679378
cn3	Fos^tm7Wag/Fos^tm7Wag Lyz2^tm1(cre)Ifo/Lyz2^+	involves: 129P2/OlaHsd * C57BL/6	MGI:5142265
cn4	Fos^tm7Wag/Fos^tm7Wag Tg(Cd4-cre)1Cwi/0	involves: 129P2/OlaHsd * C57BL/6 * DBA/2	MGI:5449725

Genotype
MGI:2679377

hm1

• Allelic Composition: Fos^tm7Wag/Fos^tm7Wag
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:85928 )

Genotype
MGI:2679378

cn2

• Allelic Composition: Fos^tm7Wag/Fos^tm7Wag; Tg(Nes-cre)1Kln/?
• Genetic Background: involves: 129P2/OlaHsd

behavior/neurological

abnormal associative learning ( J:85928 )

abnormal contextual conditioning behavior ( J:85928 )

• deficiencies in contextual fear response

abnormal spatial learning ( J:85928 )

• spatial learning anomalies were indicated in a Morris water test

nervous system

reduced long-term potentiation ( J:85928 )

• in the CA1 and CA3 regions long term potentiation is reduced after a single tetanic stimulation but normal LTP after 4 stimuli

Genotype
MGI:5142265

cn3

• Allelic Composition: Fos^tm7Wag/Fos^tm7Wag; Lyz2^tm1(cre)Ifo/Lyz2⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

immune system

increased circulating interleukin-10 level ( J:175064 )

• in LPS-treated mice

increased circulating interleukin-6 level ( J:175064 )

• in LPS-treated mice

increased circulating tumor necrosis factor level ( J:175064 )

• in LPS-treated mice

decreased interleukin-10 secretion ( J:175064 )

• from LPS-treated bone marrow macrophages

increased interleukin-6 secretion ( J:175064 )

• from LPS-treated bone marrow macrophages

increased tumor necrosis factor secretion ( J:175064 )

• from LPS-treated bone marrow macrophages

increased susceptibility to endotoxin shock ( J:175064 )

• LPS-treated bone marrow macrophages exhibit increased TNF-alpha and IL6 but decreased IL10 production compared with similarly treated wild-type cells

• LPS-treated mice exhibit increased TNF-alpha, IL6, and IL10 serum levels compared with similarly treated wild-type mice

homeostasis/metabolism

increased circulating interleukin-10 level ( J:175064 )

• in LPS-treated mice

increased circulating interleukin-6 level ( J:175064 )

• in LPS-treated mice

increased circulating tumor necrosis factor level ( J:175064 )

• in LPS-treated mice

Genotype
MGI:5449725

cn4

• Allelic Composition: Fos^tm7Wag/Fos^tm7Wag; Tg(Cd4-cre)1Cwi/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Reduced tumor growth in Fos^tm7Wag/Fos^tm7Wag Tg(Cd4-cre)1Cwi/0 mice following carcinoma cell inoculation

mortality/aging

decreased susceptibility to induced morbidity/mortality ( J:190150 )

• following inoculation with Lewis lung carcinoma

neoplasm

decreased tumor growth/size ( J:190150 )

• decreased lung tumor number and growth following inoculation with Lewis lung carcinoma or B16-F10 melanoma

immune system

decreased CD4-positive, alpha-beta T cell number ( J:190150 )

• in the thymus

cellular

increased apoptosis ( J:190150 )

• in tumor cells following inoculation with Lewis lung carcinoma

decreased cell proliferation ( J:190150 )

• in tumor cells following inoculation with Lewis lung carcinoma

hematopoietic system

decreased CD4-positive, alpha-beta T cell number ( J:190150 )

• in the thymus