Analysis Tools
immune system
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• reduced bone marrow macrophage antibody-dependent cell-mediated cytotoxicity in spite of normal expression of Fcgr3
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• selective impairment of phagocytosis of immune complexes IgG2a and IgG3, but not IgG1, in bone marrow macrophages
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• 2 to 5 fold increases in the level of IgG subclasses following immunization
• no difference in antibody half-life, indicating an increased number of antibody-forming cells
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• impaired bone marrow macrophage antigen presentation
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• inflammatory response was slower to develop than in wild-type mice
• swelling peaked at 70% that of the levels reached in wild-type mice
• inflammation resolved more rapidly than in wild-type mice
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hematopoietic system
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• selective impairment of phagocytosis of immune complexes IgG2a and IgG3, but not IgG1, in bone marrow macrophages
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• 2 to 5 fold increases in the level of IgG subclasses following immunization
• no difference in antibody half-life, indicating an increased number of antibody-forming cells
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• impaired bone marrow macrophage antigen presentation
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cellular
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• selective impairment of phagocytosis of immune complexes IgG2a and IgG3, but not IgG1, in bone marrow macrophages
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