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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Tnnt2-cre)5Blh
transgene insertion 5, Brigid L Hogan
MGI:2679081
Summary 15 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Vegfatm2Gne/Vegfatm2Gne
Tg(Tnnt2-cre)5Blh/0
involves: 129/Sv * C57BL/6 * DBA MGI:5471120
cn2
Lims1tm1.1Chen/Lims1tm1.1Chen
Lims2tm1.1Chen/Lims2tm1.1Chen
Tg(Tnnt2-cre)5Blh/0
involves: 129/Sv * C57BL/6 * DBA/2 MGI:4867270
cn3
Fgf8tm1.3Mrt/Fgf8tm1.4Mrt
Tg(Tnnt2-cre)5Blh/0
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * DBA/2 MGI:3818074
cn4
Bmp4tm1Blh/Bmp4tm3.1Blh
Tg(Tnnt2-cre)5Blh/0
involves: 129S/Sv * Black Swiss * C57BL/6 * DBA/2 * ICR MGI:2679084
cn5
Pdlim5tm1Chen/Pdlim5tm1Chen
Tg(Tnnt2-cre)5Blh/?
involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6 * DBA/2 MGI:5284901
cn6
Cxadrtm1Mds/Cxadrtm1.1Mds
Tg(Tnnt2-cre)5Blh/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2 MGI:3711513
cn7
Cxadrtm1Mds/Cxadrtm1Mds
Tg(Tnnt2-cre)5Blh/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2 MGI:3711514
cn8
Lims1tm1.1Chen/Lims1tm1.1Chen
Tg(Tnnt2-cre)5Blh/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2 MGI:4867271
cn9
Hand2tm1Cse/Hand2+
Tg(Tnnt2-cre)5Blh/0
involves: 129S1/Sv * C57BL/6J * DBA/2 MGI:4417974
cn10
Bmp4tm3.1Blh/Bmp4tm3.1Blh
Tg(Tnnt2-cre)5Blh/0
involves: 129S6/SvEvTac * C57BL/6 * DBA/2 * ICR MGI:2679083
cn11
Fkbp1atm1.1Shou/Fkbp1atm1Zuk
Tg(Tnnt2-cre)5Blh/0
involves: 129S7/SvEvBrd * C57BL/6 * DBA/2 MGI:5490248
cn12
Smotm2Amc/Smotm2.1Amc
Tg(Tnnt2-cre)5Blh/0
involves: 129X1/SvJ * C57BL/6 * DBA/2 MGI:4843922
cn13
Cenpftm1Dbdr/Cenpftm1Dbdr
Tg(Tnnt2-cre)5Blh/?
involves: C57BL/6 * DBA/2 MGI:5467575
cx14
Tarbp2tm1.1Dzw/Tarbp2tm1.1Dzw
Tg(tetO-Mir208a)#Dzw/?
Tg(Tnnt2-cre)5Blh/?
involves: 129 * C3H * C57BL/6 * DBA/2J MGI:5645730
cx15
Tarbp2tm1.1Dzw/Tarbp2tm1.1Dzw
Tg(Tnnt2-cre)5Blh/?
involves: 129 * C57BL/6 * DBA/2J MGI:5645529


Genotype
MGI:5471120
cn1
Allelic
Composition
Vegfatm2Gne/Vegfatm2Gne
Tg(Tnnt2-cre)5Blh/0
Genetic
Background
involves: 129/Sv * C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Tnnt2-cre)5Blh mutation (1 available)
Vegfatm2Gne mutation (0 available); any Vegfa mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• complete lethality is observed after E15.5 (J:193198)
• complete lethality is observed after E15.5 (J:193198)

growth/size/body
• at E15.5, mutants are runted (J:193198)
• at E15.5, mutants are runted (J:193198)

cardiovascular system
N
(J:193198)
(J:193198)
• at E12.5, the peritruncal area and ventricular septum lack angiogenic sprouts or coronary plexuses that are observed in controls (J:193198)
• at E12.5, the peritruncal area and ventricular septum lack angiogenic sprouts or coronary plexuses that are observed in controls (J:193198)
• by E14.5, mutants have only a few immature myocardial coronary arteries (J:193198)
• by E14.5, mutants have only a few immature myocardial coronary arteries (J:193198)
• dilated subepicardial veins at E14.5 (J:193198)
• dilated subepicardial veins at E14.5 (J:193198)
• at E15.5, mutants have necrotic or ruptured septa (J:193198)
• at E15.5, mutants have necrotic or ruptured septa (J:193198)
• at E15.5, mutants display cardiac hemorrhages (J:193198)
• at E15.5, mutants display cardiac hemorrhages (J:193198)




Genotype
MGI:4867270
cn2
Allelic
Composition
Lims1tm1.1Chen/Lims1tm1.1Chen
Lims2tm1.1Chen/Lims2tm1.1Chen
Tg(Tnnt2-cre)5Blh/0
Genetic
Background
involves: 129/Sv * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lims1tm1.1Chen mutation (0 available); any Lims1 mutation (32 available)
Lims2tm1.1Chen mutation (0 available); any Lims2 mutation (3 available)
Tg(Tnnt2-cre)5Blh mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die within 4 weeks (J:167114)
• mice die within 4 weeks (J:167114)
• mice die within 4 weeks (J:167114)
• mice die within 4 weeks (J:167114)

cardiovascular system
• the pectinate muscles in the atrial appendage is abnormal compared to in wild-type mice (J:167114)
• the pectinate muscles in the atrial appendage is abnormal compared to in wild-type mice (J:167114)
• cultured attached cardiomyocytes are smaller than similarly treated wild-type cells (J:167114)
• cultured attached cardiomyocytes are smaller than similarly treated wild-type cells (J:167114)
• increased (J:167114)
• increased (J:167114)
• round P1 (J:167114)
• with a bulge at the base of the right ventricle at P20 (J:167114)
• round P1 (J:167114)
• with a bulge at the base of the right ventricle at P20 (J:167114)
• the ventricular walls exhibits irregular thickness with a thickened right ventricular free wall and thin left ventricular free wall and septum compared to in wild-type mice (J:167114)
• the ventricular walls exhibits irregular thickness with a thickened right ventricular free wall and thin left ventricular free wall and septum compared to in wild-type mice (J:167114)
• at P1, myocardium exhibit widened gaps of intercalated disks with disarrayed sarcomeres and distorted Z lines compared to in wild-type mice (J:167114)
• at P10, membranes of the intercalated disk are highly convoluted and gaps are widened unlike in wild-type mice (J:167114)
• the myocardium exhibits disruption of cell-cell adhesion compared to in wild-type mice (J:167114)
• at P1, myocardium exhibit widened gaps of intercalated disks with disarrayed sarcomeres and distorted Z lines compared to in wild-type mice (J:167114)
• at P10, membranes of the intercalated disk are highly convoluted and gaps are widened unlike in wild-type mice (J:167114)
• the myocardium exhibits disruption of cell-cell adhesion compared to in wild-type mice (J:167114)
• mice exhibit disorganized trabeculae that fail to fuse and incorporate into compact myocardium unlike in wild-type mice (J:167114)
• mice exhibit disorganized trabeculae that fail to fuse and incorporate into compact myocardium unlike in wild-type mice (J:167114)
• at P20 (J:167114)
• at P20 (J:167114)
• few cardiomyocytes attack to a plate coated in fibronectin, laminin, and collagen compared with wild-type cells (J:167114)
• few cardiomyocytes attack to a plate coated in fibronectin, laminin, and collagen compared with wild-type cells (J:167114)
• progressive, resulting in death (J:167114)
• progressive, resulting in death (J:167114)

homeostasis/metabolism
• at P20 (J:167114)
• at P20 (J:167114)
• extensive in the lungs and liver (J:167114)
• extensive in the lungs and liver (J:167114)

liver/biliary system

respiratory system

growth/size/body
• gradual (J:167114)
• gradual (J:167114)

muscle
• cultured attached cardiomyocytes are smaller than similarly treated wild-type cells (J:167114)
• cultured attached cardiomyocytes are smaller than similarly treated wild-type cells (J:167114)




Genotype
MGI:3818074
cn3
Allelic
Composition
Fgf8tm1.3Mrt/Fgf8tm1.4Mrt
Tg(Tnnt2-cre)5Blh/0
Genetic
Background
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf8tm1.3Mrt mutation (1 available); any Fgf8 mutation (8 available)
Fgf8tm1.4Mrt mutation (0 available); any Fgf8 mutation (8 available)
Tg(Tnnt2-cre)5Blh mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
N
• no outflow tract or right ventricle defects are observed at E10.5 and no outflow tract septation defects are seen in term fetuses (J:109474)
• no outflow tract or right ventricle defects are observed at E10.5 and no outflow tract septation defects are seen in term fetuses (J:109474)




Genotype
MGI:2679084
cn4
Allelic
Composition
Bmp4tm1Blh/Bmp4tm3.1Blh
Tg(Tnnt2-cre)5Blh/0
Genetic
Background
involves: 129S/Sv * Black Swiss * C57BL/6 * DBA/2 * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp4tm1Blh mutation (2 available); any Bmp4 mutation (5 available)
Bmp4tm3.1Blh mutation (0 available); any Bmp4 mutation (5 available)
Tg(Tnnt2-cre)5Blh mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• no neonates are found (J:86001)
• no neonates are found (J:86001)

cardiovascular system
• at E12.5 about a 20% decrease in proliferation is detected in the atrioventricular cushions but not in other areas of the heart (J:86001)
• at E12.5 about a 20% decrease in proliferation is detected in the atrioventricular cushions but not in other areas of the heart (J:86001)
• present in 80% of embryos at E15.5 - E16.5 (J:86001)
• present in 80% of embryos at E15.5 - E16.5 (J:86001)
• single atrioventricular junction with a common valve (J:86001)
• single atrioventricular junction with a common valve (J:86001)

Mouse Models of Human Disease
OMIM ID Ref(s)
Atrioventricular Septal Defect; AVSD 606215 J:86001




Genotype
MGI:5284901
cn5
Allelic
Composition
Pdlim5tm1Chen/Pdlim5tm1Chen
Tg(Tnnt2-cre)5Blh/?
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdlim5tm1Chen mutation (0 available); any Pdlim5 mutation (29 available)
Tg(Tnnt2-cre)5Blh mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• left ventricular chamber size is significantly enlarged (J:175042)
• left ventricular chamber size is significantly enlarged (J:175042)
• develop dilated cardiomyopathy starting at 3 months of age (J:175042)
• develop dilated cardiomyopathy starting at 3 months of age (J:175042)
• left ventricular function significantly impaired as measured by fractional shortening (J:175042)
• left ventricular function significantly impaired as measured by fractional shortening (J:175042)

muscle
• develop dilated cardiomyopathy starting at 3 months of age (J:175042)
• develop dilated cardiomyopathy starting at 3 months of age (J:175042)
• left ventricular function significantly impaired as measured by fractional shortening (J:175042)
• left ventricular function significantly impaired as measured by fractional shortening (J:175042)




Genotype
MGI:3711513
cn6
Allelic
Composition
Cxadrtm1Mds/Cxadrtm1.1Mds
Tg(Tnnt2-cre)5Blh/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cxadrtm1.1Mds mutation (0 available); any Cxadr mutation (2 available)
Cxadrtm1Mds mutation (0 available); any Cxadr mutation (2 available)
Tg(Tnnt2-cre)5Blh mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• no live conditional null mice are found at 4 weeks after birth; embryos at E10.5; mice display identical phenotype to Cxadrtm1.1Mds homozygotes (J:121400)
• no live conditional null mice are found at 4 weeks after birth; embryos at E10.5; mice display identical phenotype to Cxadrtm1.1Mds homozygotes (J:121400)

cardiovascular system
• at E10.5, engorgement of the cardinal veins is apparent (J:121400)
• at E10.5, engorgement of the cardinal veins is apparent (J:121400)
• hyperplasia of proximal heart tube is seen at E10.5 (J:121400)
• hyperplasia of proximal heart tube is seen at E10.5 (J:121400)
• sinuatrial valves located at junction between sinus venosus and atrium in wild-type embryos, are absent (J:121400)
• sinuatrial valves located at junction between sinus venosus and atrium in wild-type embryos, are absent (J:121400)




Genotype
MGI:3711514
cn7
Allelic
Composition
Cxadrtm1Mds/Cxadrtm1Mds
Tg(Tnnt2-cre)5Blh/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cxadrtm1Mds mutation (0 available); any Cxadr mutation (2 available)
Tg(Tnnt2-cre)5Blh mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• no live conditional null mice are found at 4 weeks after birth; embryos at E10.5; mice display identical phenotype to Cxadrtm1.1Mds homozygotes (J:121400)
• no live conditional null mice are found at 4 weeks after birth; embryos at E10.5; mice display identical phenotype to Cxadrtm1.1Mds homozygotes (J:121400)

cardiovascular system
• at E10.5, engorgement of the cardinal veins is apparent (J:121400)
• at E10.5, engorgement of the cardinal veins is apparent (J:121400)
• hyperplasia of proximal heart tube is seen at E10.5 (J:121400)
• hyperplasia of proximal heart tube is seen at E10.5 (J:121400)
• sinuatrial valves located at junction between sinus venosus and atrium in wild-type embryos, are absent (J:121400)
• sinuatrial valves located at junction between sinus venosus and atrium in wild-type embryos, are absent (J:121400)




Genotype
MGI:4867271
cn8
Allelic
Composition
Lims1tm1.1Chen/Lims1tm1.1Chen
Tg(Tnnt2-cre)5Blh/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lims1tm1.1Chen mutation (0 available); any Lims1 mutation (32 available)
Tg(Tnnt2-cre)5Blh mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
N
• mice exhibit normal heart morphology and physiology under normal conditions (J:167114)
• mice exhibit normal heart morphology and physiology under normal conditions (J:167114)
• following infarct induction (J:167114)
• following infarct induction (J:167114)
• following infarct induction, mice exhibit reduced fractional shortening and increased infarct size and scar tissue with hemorrhage compared with similarly treated wild-type mice (J:167114)
• following infarct induction, mice exhibit reduced fractional shortening and increased infarct size and scar tissue with hemorrhage compared with similarly treated wild-type mice (J:167114)

homeostasis/metabolism
• following infarct induction, mice exhibit reduced fractional shortening and increased infarct size and scar tissue with hemorrhage compared with similarly treated wild-type mice (J:167114)
• following infarct induction, mice exhibit reduced fractional shortening and increased infarct size and scar tissue with hemorrhage compared with similarly treated wild-type mice (J:167114)

muscle
• following infarct induction (J:167114)
• following infarct induction (J:167114)




Genotype
MGI:4417974
cn9
Allelic
Composition
Hand2tm1Cse/Hand2+
Tg(Tnnt2-cre)5Blh/0
Genetic
Background
involves: 129S1/Sv * C57BL/6J * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hand2tm1Cse mutation (0 available); any Hand2 mutation (1 available)
Tg(Tnnt2-cre)5Blh mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• embryos survive at the expected Mendelian ratio until 9.5 dpc, with viablility dropping until 12.5 dpc after which no viable embryos are recovered (J:155265)
• embryos survive at the expected Mendelian ratio until 9.5 dpc, with viablility dropping until 12.5 dpc after which no viable embryos are recovered (J:155265)

cardiovascular system
• at 12.5 dpc, surviving embryos show hypoplastic outflow tract (J:155265)
• at 12.5 dpc, surviving embryos show hypoplastic outflow tract (J:155265)
• at 10.5 dpc severely affected embryos exhibit only a single clearly defined ventricle (J:155265)
• at 10.5 dpc severely affected embryos exhibit only a single clearly defined ventricle (J:155265)
• at 12.5 dpc, surviving embryos show hypoplastic right ventricle (J:155265)
• at 12.5 dpc, surviving embryos show hypoplastic right ventricle (J:155265)




Genotype
MGI:2679083
cn10
Allelic
Composition
Bmp4tm3.1Blh/Bmp4tm3.1Blh
Tg(Tnnt2-cre)5Blh/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * DBA/2 * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp4tm3.1Blh mutation (0 available); any Bmp4 mutation (5 available)
Tg(Tnnt2-cre)5Blh mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

cardiovascular system
N
• no outflow tract abnormalities are seen (J:86001)
• no outflow tract abnormalities are seen (J:86001)
• atrial septal defect similar to that in mice heterozygous for Bmp4tm1Blh and Bmp4tm3.1Blh (J:86001)
• atrial septal defect similar to that in mice heterozygous for Bmp4tm1Blh and Bmp4tm3.1Blh (J:86001)

Mouse Models of Human Disease
OMIM ID Ref(s)
Atrioventricular Septal Defect; AVSD 606215 J:86001




Genotype
MGI:5490248
cn11
Allelic
Composition
Fkbp1atm1.1Shou/Fkbp1atm1Zuk
Tg(Tnnt2-cre)5Blh/0
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fkbp1atm1.1Shou mutation (0 available); any Fkbp1a mutation (11 available)
Fkbp1atm1Zuk mutation (0 available); any Fkbp1a mutation (11 available)
Tg(Tnnt2-cre)5Blh mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
N
• animals show normal ventricular chamber formation; normal trabeculation and compaction in ventricles are observed (J:195489)
• animals show normal ventricular chamber formation; normal trabeculation and compaction in ventricles are observed (J:195489)




Genotype
MGI:4843922
cn12
Allelic
Composition
Smotm2Amc/Smotm2.1Amc
Tg(Tnnt2-cre)5Blh/0
Genetic
Background
involves: 129X1/SvJ * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smotm2.1Amc mutation (0 available); any Smo mutation (9 available)
Smotm2Amc mutation (1 available); any Smo mutation (9 available)
Tg(Tnnt2-cre)5Blh mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
N
• mice exhibit normal outflow tract development (J:135134)
• mice exhibit normal outflow tract development (J:135134)




Genotype
MGI:5467575
cn13
Allelic
Composition
Cenpftm1Dbdr/Cenpftm1Dbdr
Tg(Tnnt2-cre)5Blh/?
Genetic
Background
involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cenpftm1Dbdr mutation (0 available); any Cenpf mutation (7 available)
Tg(Tnnt2-cre)5Blh mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
N
• development of heart structure is grossly normal (J:185133)
• development of heart structure is grossly normal (J:185133)
• modest reduction in coronary vasculature (J:185133)
• modest reduction in coronary vasculature (J:185133)
• thinner walls (J:185133)
• thinner walls (J:185133)
• costamere structure is impaired (J:185133)
• decreased number of myocytes in adults (J:185133)
• costamere structure is impaired (J:185133)
• decreased number of myocytes in adults (J:185133)
• intercalated disc number is reduced 3.5 fold in mature ventricles (J:185133)
• intercalated disc number is reduced 3.5 fold in mature ventricles (J:185133)
• trabeculae are thinner and blunted (J:185133)
• trabeculae are thinner and blunted (J:185133)
• smaller ventricles (J:185133)
• smaller ventricles (J:185133)
• weight at 4 days of age is 8.2mg compared to 10.5mg for controls (J:185133)
• weight at 4 days of age is 8.2mg compared to 10.5mg for controls (J:185133)
• smaller ventricles (J:185133)
• smaller ventricles (J:185133)
• internal dimension somewhat increased (J:185133)
• internal dimension somewhat increased (J:185133)
• modest reduction in epicardial thickness (J:185133)
• modest reduction in epicardial thickness (J:185133)
• cardiac fibrosis in adults (J:185133)
• cardiac fibrosis in adults (J:185133)
• decreasing ventricular function with age (J:185133)
• decreasing ventricular function with age (J:185133)
• three fold decrease in prenatal myocardiocyte proliferation (J:185133)
• three fold decrease in prenatal myocardiocyte proliferation (J:185133)
• at 3 months (J:185133)
• at 3 months (J:185133)
• P-P intervals greater than 200 ms (J:185133)
• slowing sinus rhythms (J:185133)
• P-P intervals greater than 200 ms (J:185133)
• slowing sinus rhythms (J:185133)
• lower myocyte mitotic rates on days 1-4 after birth (J:185133)
• lower myocyte mitotic rates on days 1-4 after birth (J:185133)

growth/size/body
• normal to slightly smaller body size (J:185133)
• normal to slightly smaller body size (J:185133)

mortality/aging
• 20% mortality in the 12 to 21 month age period (J:185133)
• 20% mortality in the 12 to 21 month age period (J:185133)

muscle
• costamere structure is impaired (J:185133)
• decreased number of myocytes in adults (J:185133)
• costamere structure is impaired (J:185133)
• decreased number of myocytes in adults (J:185133)
• intercalated disc number is reduced 3.5 fold in mature ventricles (J:185133)
• intercalated disc number is reduced 3.5 fold in mature ventricles (J:185133)
• trabeculae are thinner and blunted (J:185133)
• trabeculae are thinner and blunted (J:185133)
• three fold decrease in prenatal myocardiocyte proliferation (J:185133)
• three fold decrease in prenatal myocardiocyte proliferation (J:185133)

cellular
• three fold decrease in prenatal myocardiocyte proliferation (J:185133)
• three fold decrease in prenatal myocardiocyte proliferation (J:185133)




Genotype
MGI:5645730
cx14
Allelic
Composition
Tarbp2tm1.1Dzw/Tarbp2tm1.1Dzw
Tg(tetO-Mir208a)#Dzw/?
Tg(Tnnt2-cre)5Blh/?
Genetic
Background
involves: 129 * C3H * C57BL/6 * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tarbp2tm1.1Dzw mutation (0 available); any Tarbp2 mutation (17 available)
Tg(tetO-Mir208a)#Dzw mutation (0 available)
Tg(Tnnt2-cre)5Blh mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
N
• transgenic expression of Mir208a prevents the onset of dilated cardiomyopathy in cardiac conditional knockouts of Tarbp2 and results in mice with normal heart morphology, histology, and function (J:222613)
• transgenic expression of Mir208a prevents the onset of dilated cardiomyopathy in cardiac conditional knockouts of Tarbp2 and results in mice with normal heart morphology, histology, and function (J:222613)




Genotype
MGI:5645529
cx15
Allelic
Composition
Tarbp2tm1.1Dzw/Tarbp2tm1.1Dzw
Tg(Tnnt2-cre)5Blh/?
Genetic
Background
involves: 129 * C57BL/6 * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tarbp2tm1.1Dzw mutation (0 available); any Tarbp2 mutation (17 available)
Tg(Tnnt2-cre)5Blh mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• Although homozygotes are born in normal mendelian ratio indicating no embryonic lethality, more than 80 percent of these cardiac conditional knockout homozygotes die by 4 months of age and none survive beyond 8 months of age (J:222613)
• Although homozygotes are born in normal mendelian ratio indicating no embryonic lethality, more than 80 percent of these cardiac conditional knockout homozygotes die by 4 months of age and none survive beyond 8 months of age (J:222613)

cardiovascular system
• although gross morphology of the heart is normal at 2 weeks of age, atrial dilation is found by 3 weeks of age and substantial dilation of both atrial and ventricular chambers is found by 1 month of age and is severe in the homozygotes that survive to 2 months of age, yet cardiomyocyte size appears normal (J:222613)
• neonatal adeno-associated virus-mediated delivery of Tarbp2 or transgenic expression of Mir208a suppresses chamber dilation, permits normal cardiac morphology and restores viability as does knockdown of Sox6, while Tnnt2-dirven viral-mediated overexpression of Sox6 recapitulates the phenotype of cardiac conditional null Tarbp2 (J:222613)
• although gross morphology of the heart is normal at 2 weeks of age, atrial dilation is found by 3 weeks of age and substantial dilation of both atrial and ventricular chambers is found by 1 month of age and is severe in the homozygotes that survive to 2 months of age, yet cardiomyocyte size appears normal (J:222613)
• neonatal adeno-associated virus-mediated delivery of Tarbp2 or transgenic expression of Mir208a suppresses chamber dilation, permits normal cardiac morphology and restores viability as does knockdown of Sox6, while Tnnt2-dirven viral-mediated overexpression of Sox6 recapitulates the phenotype of cardiac conditional null Tarbp2 (J:222613)
• by 3 weeks of age atrial dilation is found (J:222613)
• by 3 weeks of age atrial dilation is found (J:222613)
• by 1 month of age dilation of the ventricular chambers is also found (J:222613)
• by 1 month of age dilation of the ventricular chambers is also found (J:222613)
• by 2 weeks of age the left ventricular fractional shortening is decreased and this drops precipitously resulting in severe systolic dysfunction by 1 month of age (J:222613)
• by 2 weeks of age the left ventricular fractional shortening is decreased and this drops precipitously resulting in severe systolic dysfunction by 1 month of age (J:222613)

muscle
• by 2 weeks of age the left ventricular fractional shortening is decreased and this drops precipitously resulting in severe systolic dysfunction by 1 month of age (J:222613)
• by 2 weeks of age the left ventricular fractional shortening is decreased and this drops precipitously resulting in severe systolic dysfunction by 1 month of age (J:222613)





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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory