All Phenotypes Pias2<Gt(pT1Betageo)1Ruiz> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Pias2^{Gt(pT1Betageo)1Ruiz}
gene trap 1, Patricia Ruiz
MGI:2678428

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pias2^{Gt(pT1Betageo)1Ruiz}/Pias2^{Gt(pT1Betageo)1Ruiz}	involves: 129P2/OlaHsd * C57BL/6	MGI:2678495

Allelic Composition	Pias2^{Gt(pT1Betageo)1Ruiz}/Pias2^{Gt(pT1Betageo)1Ruiz}
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pias2^{Gt(pT1Betageo)1Ruiz} mutation (0 available); any Pias2 mutation (75 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:224819 )

N	• males are fertile • sperm appear normal and are motile

abnormal testis physiology ( J:224819 )

• intratesticular testosterone levels increased 67%

• FSH and LH levels are normal

abnormal reproductive system morphology ( J:224819 )

oligozoospermia ( J:224819 )

• epidymal sperm count reduced 19%

abnormal testis morphology ( J:224819 )

small seminiferous tubules ( J:224819 )

• diameter reduced 67% although reduction is not significant

• both lumen and wall thickness are affected

decreased testis weight ( J:224819 )

• absolute testicular weight reduced 23%

• relative testicular weight reduced 25%

growth/size/body

growth/size/body region phenotype ( J:224819 )

N	• viable and growth normal

cellular

oligozoospermia ( J:224819 )

• epidymal sperm count reduced 19%

increased apoptosis ( J:224819 )

• increased number of apoptotic cells , mostly among primary spermatocytes

endocrine/exocrine glands

abnormal testis morphology ( J:224819 )

small seminiferous tubules ( J:224819 )

• diameter reduced 67% although reduction is not significant

• both lumen and wall thickness are affected

decreased testis weight ( J:224819 )

• absolute testicular weight reduced 23%

• relative testicular weight reduced 25%

abnormal testis physiology ( J:224819 )

• intratesticular testosterone levels increased 67%

• FSH and LH levels are normal

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