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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ntrk1tm1Apat
targeted mutation 1, Ardem Patapoutian
MGI:2678328
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ntrk1tm1Apat/Ntrk1tm1Apat involves: 129S1/Sv MGI:3052172
cx2
Baxtm1Sjk/Baxtm1Sjk
Ntrk1tm1Apat/Ntrk1tm1Apat
involves: 129S1/Sv * 129X1/SvJ MGI:4413457


Genotype
MGI:3052172
hm1
Allelic
Composition
Ntrk1tm1Apat/Ntrk1tm1Apat
Genetic
Background
involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ntrk1tm1Apat mutation (1 available); any Ntrk1 mutation (37 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• a 70 - 90% reduction in sensory neuron number is seen




Genotype
MGI:4413457
cx2
Allelic
Composition
Baxtm1Sjk/Baxtm1Sjk
Ntrk1tm1Apat/Ntrk1tm1Apat
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Baxtm1Sjk mutation (1 available); any Bax mutation (26 available)
Ntrk1tm1Apat mutation (1 available); any Ntrk1 mutation (37 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• E14.5, extension of hind limb nerves is defective compared to in wild-type mice
• extension of the lateral plantar nerve is reduced 9% compared to in wild-type mice
• at E15.5, the number and order of branches in the medial digital branch of the lateral plantar nerve in the fifth digit are impaired compared to in wild-type mice





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/12/2022
MGI 6.17
The Jackson Laboratory