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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Cops3tm2Jrl
targeted mutation 2, James R Lupski
MGI:2678262
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Cops3tm2Jrl/Cops3tm2Jrl involves: 129S7/SvEvBrd * C57BL/6 MGI:2678266
ht2
Cops3tm1Jrl/Cops3tm2Jrl involves: 129S7/SvEvBrd * C57BL/6 MGI:2678268


Genotype
MGI:2678266
hm1
Allelic
Composition
Cops3tm2Jrl/Cops3tm2Jrl
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cops3tm2Jrl mutation (0 available); any Cops3 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• no homozygous mice are born




Genotype
MGI:2678268
ht2
Allelic
Composition
Cops3tm1Jrl/Cops3tm2Jrl
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cops3tm1Jrl mutation (0 available); any Cops3 mutation (20 available)
Cops3tm2Jrl mutation (0 available); any Cops3 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• no homozygotes are born
• no homozygotes recovered at E9.5-11.5
• at E8.5 a single small homozygote with head anlage but lacking other structural elements found, also 7 resorbing embryos
• E7.5 1/5-1/4 normal size homozygotes and elongated shape

embryo
N
• histologically normal visceral and parietal endoderm is present at E5.5 and the ectoplacental cone is forming
• at E6.5 and E7.5, only two germ layers are present
• E7.5 embryos apparently arrested prior to gastrulation
• at 6.5 dpc, mutant embryos exhibit slight growth retardation
• at E5.5, a disorganized epiblast is seen
• at E6.5, the number of epiblast cells appeared to be greatly reduced and the cells were disorganized
• at E7.5, more epiblast cells are apparent, but cells were more disorganized
• apoptosis of epiblast cells occurs by E6.5
• no indications of mesoderm formation at E7.5
• mutant embryos showed no Brachyury expression, a marker of mesodermal cells, at E7.5
• inner cell mass cells from cultured blastocysts cease to develop normally after 3 days in culture
• cell numbers are greatly reduced by days 5-6 in culture
• cavity is not obvious at E5.5
• a more obvious pro-amniotic cavity is present at E6.5 that contains increased numbers of dead cells, presumably from the epiblast

growth/size/body
• at 6.5 dpc, mutant embryos exhibit slight growth retardation





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/13/2018
MGI 6.11
The Jackson Laboratory