mortality/aging
|
• death usually at 6- 10 months of age
|
behavior/neurological
 |
• females do not nurse their young well
(J:98859)
|
immune system
|
• accelerated atrophy with age
|
hematopoietic system
|
• accelerated atrophy with age
|
integument
|
• coat is normal up to 12 days when hair loss starts to occur, first around the eyes and progressing in the direction of the tail, with total loss within 2 weeks
|
|
• extensive hyperkeratosis in hair follicles
|
long toenails
(
J:98859
)
|
• excessively long and curved, especially the toes of the hind limbs
|
|
• repeatedly shed and regrown becoming more abnormal with age
|
|
• very extensive hyperkeratosis in hair follicles
|
|
• formation of hypertrophic and excessively large utriculi that were filled with masses of cornified material in the dermis
|
dermal cysts
(
J:98859
)
|
• extensive development of dermal cysts with advancing age leading to thickening of the skin
|
|
• follicular and epidermal hyperkeratosis
|
flaky skin
(
J:98859
)
|
• aging mice have a waxy deposition on the skin that peels off in large flakes
|
loose skin
(
J:98859
)
|
• skin becomes loose, forming rhinoceros-like folds
|
wrinkled skin
(
J:98859
)
thick skin
(
J:98859
)
|
• skin becomes thick and wrinkled with age
|
cellular
|
• very extensive hyperkeratosis in hair follicles
|
Mouse Models of Human Disease |
OMIM ID | Ref(s) | |
| Alopecia Universalis Congenita; ALUNC | 203655 | J:98859 | |
| Atrichia with Papular Lesions; APL | 209500 | J:98859 | |