Mouse Genome Informatics
hm1
    Hrrhsl/Hrrhsl
involves: BALB/c
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• death usually at 6- 10 months of age

behavior/neurological
• females do not nurse their young well (J:98859)

immune system
• accelerated atrophy with age

hematopoietic system
• accelerated atrophy with age

integument
• coat is normal up to 12 days when hair loss starts to occur, first around the eyes and progressing in the direction of the tail, with total loss within 2 weeks
• extensive hyperkeratosis in hair follicles
• excessively long and curved, especially the toes of the hind limbs
• repeatedly shed and regrown becoming more abnormal with age
• very extensive hyperkeratosis in hair follicles
• formation of hypertrophic and excessively large utriculi that were filled with masses of cornified material in the dermis
• extensive development of dermal cysts with advancing age leading to thickening of the skin
• follicular and epidermal hyperkeratosis
• aging mice have a waxy deposition on the skin that peels off in large flakes
• skin becomes loose, forming rhinoceros-like folds
• skin becomes thick and wrinkled with age

cellular
• very extensive hyperkeratosis in hair follicles

endocrine/exocrine glands
• accelerated atrophy with age