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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Mafbtm1Mhs
targeted mutation 1, Michael H Sieweke
MGI:2677917
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Mafbtm1Mhs/Mafbtm1Mhs involves: 129S1/Sv * 129X1/SvJ MGI:2677920


Genotype
MGI:2677920
hm1
Allelic
Composition
Mafbtm1Mhs/Mafbtm1Mhs
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mafbtm1Mhs mutation (0 available); any Mafb mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die within 2 hours of birth exhibiting respiratory distress and cyanosis

homeostasis/metabolism

respiratory system
• mutants exhibit defective respiratory rhythmogenesis as indicated by a reduced frequency of inspiratory bursts in E18.5 brainstems
• mice do not initiate normal breathing
• intermittent deep gasping rather than normal breathing
• mutants do not initiate normal breathing behavior and ventilate essentially by intermittent deep gasping movements
• defective rhythmogenesis due to defects in the central respiratory control
• the lungs, trachea, and intercostal musculature appear normal

nervous system
N
• no defects observed with the innervation of the diaphragm
• overall organization of the preBotzinger complex, a putative principle sit of respiratory rhythmogenesis, is disrupted with a loss of about 1/3 of NK1R-positive cells
• brainstems are unresponsive to electrolytic lesion or stimulation of the preBotzinger complex
• brainstems are unresponsive to modulation of respiratory rhythmogenesis by hypoxia or peptidergic input





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory