About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Hbab2(th)
352HB deletion, Oak Ridge
MGI:2677682
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Hbab2(th)/Hbab2(th) SEC-Hbab2(th) MGI:3720084
ht2
Hbab2(th)/Hba+ either: (involves: 101 * SEC) or (involves: 101 * C57BL * SEC) MGI:3720079
ht3
Hbab2(th)/Hba+ involves: 101/Rl * SEC/Rl MGI:3720078
ht4
Hbab2(th)/Hba+ involves: C57BL6J * SEC MGI:3720080
ht5
Hbab2(th)/Hba+ SEC-Hbab2(th) MGI:3720082


Genotype
MGI:3720084
hm1
Allelic
Composition
Hbab2(th)/Hbab2(th)
Genetic
Background
SEC-Hbab2(th)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hbab2(th) mutation (0 available); any Hba mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

embryo
• at 86h post mating many homozygous embryos are still in the morula stage while wild-type littermates have reached the blastocyst stage
• at E5.5 some embryos remain in the late blastocyst stage and these have pycnotic cells in the trophectoderm
• at E5.5 some embryos remain in the late blastocyst stage and these have pycnotic cells in the trophectoderm

growth/size/body
• at 86h post mating many homozygous embryos are still in the morula stage while wild-type littermates have reached the blastocyst stage
• at E5.5 some embryos remain in the late blastocyst stage and these have pycnotic cells in the trophectoderm




Genotype
MGI:3720079
ht2
Allelic
Composition
Hbab2(th)/Hba+
Genetic
Background
either: (involves: 101 * SEC) or (involves: 101 * C57BL * SEC)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hbab2(th) mutation (0 available); any Hba mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• reduced mean cell volume despite increased red cell numbers
• red cells of irregular size and shape with pitted surfaces and blebs are seen
• increase in the percentage of red blood cells with flattened or doughnut shape (26%) compared to controls
• red cells are 75 - 80% the size of wild-type cells
• increase in the percentage of acanthocytes and red blood cells with teardrop shape (43.2%) compared to controls
• Background Sensitivity: white cell numbers are increased in mice crossed to C57BL mice but not in those crossed to SEC mice

immune system
• Background Sensitivity: white cell numbers are increased in mice crossed to C57BL mice but not in those crossed to SEC mice

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
alpha thalassemia DOID:1099 OMIM:604131
J:123943




Genotype
MGI:3720078
ht3
Allelic
Composition
Hbab2(th)/Hba+
Genetic
Background
involves: 101/Rl * SEC/Rl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hbab2(th) mutation (0 available); any Hba mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• display a diminished fast band, higher than normal solubility, and precipitates containing few, large, found aggregates of crystals
• chromium labelled erythrocytes transplanted from heterozygous males into wild-type hosts have a half-life of only 10.3 days whereas that from normal donors into normal hosts is 12.7 days
• the calculated lifespan of transplanted heterozygous erythrocytes is shorter than of transplanted normal erythrocytes

mortality/aging
• the mean age of death is less than normal




Genotype
MGI:3720080
ht4
Allelic
Composition
Hbab2(th)/Hba+
Genetic
Background
involves: C57BL6J * SEC
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hbab2(th) mutation (0 available); any Hba mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• fewer than expected heterozygous mice are found at weaning (37% compared to the expected 50%)

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
alpha thalassemia DOID:1099 OMIM:604131
J:32654




Genotype
MGI:3720082
ht5
Allelic
Composition
Hbab2(th)/Hba+
Genetic
Background
SEC-Hbab2(th)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hbab2(th) mutation (0 available); any Hba mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• at E13.5 - E15.5, eosinophilic inclusions are seen in liver derived erythrocytes
• however, no abnormalities are seen in yolk-sac derived nucleated erythrocytes

growth/size/body
N
• unlike mice heterozygous for SEC-Hbab3(th), body weights of heterozygous mice are similar to control littermates

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
alpha thalassemia DOID:1099 OMIM:604131
J:6452





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/08/2017
MGI 6.10
The Jackson Laboratory