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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Hbab2(th)
352HB deletion, Oak Ridge
MGI:2677682
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Hbab2(th)/Hbab2(th) SEC-Hbab2(th) MGI:3720084
ht2
Hbab2(th)/Hba+ either: (involves: 101 * SEC) or (involves: 101 * C57BL * SEC) MGI:3720079
ht3
Hbab2(th)/Hba+ involves: 101/Rl * SEC/Rl MGI:3720078
ht4
Hbab2(th)/Hba+ involves: C57BL6J * SEC MGI:3720080
ht5
Hbab2(th)/Hba+ SEC-Hbab2(th) MGI:3720082


Genotype
MGI:3720084
hm1
Allelic
Composition
Hbab2(th)/Hbab2(th)
Genetic
Background
SEC-Hbab2(th)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hbab2(th) mutation (0 available); any Hba mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

embryo
• at 86h post mating many homozygous embryos are still in the morula stage while wild-type littermates have reached the blastocyst stage
• at E5.5 some embryos remain in the late blastocyst stage and these have pycnotic cells in the trophectoderm
• at E5.5 some embryos remain in the late blastocyst stage and these have pycnotic cells in the trophectoderm

growth/size/body
• at 86h post mating many homozygous embryos are still in the morula stage while wild-type littermates have reached the blastocyst stage
• at E5.5 some embryos remain in the late blastocyst stage and these have pycnotic cells in the trophectoderm




Genotype
MGI:3720079
ht2
Allelic
Composition
Hbab2(th)/Hba+
Genetic
Background
either: (involves: 101 * SEC) or (involves: 101 * C57BL * SEC)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hbab2(th) mutation (0 available); any Hba mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• reduced mean cell volume despite increased red cell numbers
• red cells of irregular size and shape with pitted surfaces and blebs are seen
• increase in the percentage of red blood cells with flattened or doughnut shape (26%) compared to controls
• red cells are 75 - 80% the size of wild-type cells
• increase in the percentage of acanthocytes and red blood cells with teardrop shape (43.2%) compared to controls
• Background Sensitivity: white cell numbers are increased in mice crossed to C57BL mice but not in those crossed to SEC mice

immune system
• Background Sensitivity: white cell numbers are increased in mice crossed to C57BL mice but not in those crossed to SEC mice

Mouse Models of Human Disease
OMIM ID Ref(s)
Alpha-Thalassemia 604131 J:123943




Genotype
MGI:3720078
ht3
Allelic
Composition
Hbab2(th)/Hba+
Genetic
Background
involves: 101/Rl * SEC/Rl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hbab2(th) mutation (0 available); any Hba mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• display a diminished fast band, higher than normal solubility, and precipitates containing few, large, found aggregates of crystals
• chromium labelled erythrocytes transplanted from heterozygous males into wild-type hosts have a half-life of only 10.3 days whereas that from normal donors into normal hosts is 12.7 days
• the calculated lifespan of transplanted heterozygous erythrocytes is shorter than of transplanted normal erythrocytes

mortality/aging
• the mean age of death is less than normal




Genotype
MGI:3720080
ht4
Allelic
Composition
Hbab2(th)/Hba+
Genetic
Background
involves: C57BL6J * SEC
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hbab2(th) mutation (0 available); any Hba mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• fewer than expected heterozygous mice are found at weaning (37% compared to the expected 50%)

Mouse Models of Human Disease
OMIM ID Ref(s)
Alpha-Thalassemia 604131 J:32654




Genotype
MGI:3720082
ht5
Allelic
Composition
Hbab2(th)/Hba+
Genetic
Background
SEC-Hbab2(th)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hbab2(th) mutation (0 available); any Hba mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• at E13.5 - E15.5, eosinophilic inclusions are seen in liver derived erythrocytes
• however, no abnormalities are seen in yolk-sac derived nucleated erythrocytes

growth/size/body
N
• unlike mice heterozygous for SEC-Hbab3(th), body weights of heterozygous mice are similar to control littermates

Mouse Models of Human Disease
OMIM ID Ref(s)
Alpha-Thalassemia 604131 J:6452





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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory