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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Hbab3(th)
27HB deletion, Oak Ridge
MGI:2677681
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Hbab3(th)/Hbab3(th) SEC-Hbab3(th) MGI:3720089
ht2
Hbab3(th)/Hba+ either: (involves: 101 * SEC) or (involves: 101 * C57BL * SEC) MGI:3720086
ht3
Hbab3(th)/Hba+ involves: 101 * SEC MGI:3720085
ht4
Hbab3(th)/Hba+ involves: C57BL6J * SEC MGI:3720087
ht5
Hbab3(th)/Hba+ SEC-Hbab3(th) MGI:3720088


Genotype
MGI:3720089
hm1
Allelic
Composition
Hbab3(th)/Hbab3(th)
Genetic
Background
SEC-Hbab3(th)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hbab3(th) mutation (0 available); any Hba mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

embryo
• at 86h post mating most homozygous embryos are still in the morula stage while wild-type littermates have reached the blastocyst stage
• at E5.5 some embryos remain in the late blastocyst stage and these have pycnotic cells in the trophectoderm
• at E5.5 some embryos remain in the late blastocyst stage and these have pycnotic cells in the trophectoderm

growth/size/body
• at 86h post mating most homozygous embryos are still in the morula stage while wild-type littermates have reached the blastocyst stage
• at E5.5 some embryos remain in the late blastocyst stage and these have pycnotic cells in the trophectoderm




Genotype
MGI:3720086
ht2
Allelic
Composition
Hbab3(th)/Hba+
Genetic
Background
either: (involves: 101 * SEC) or (involves: 101 * C57BL * SEC)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hbab3(th) mutation (0 available); any Hba mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• reduced mean cell volume despite increased red cell numbers
• red cells of irregular size and shape with pitted surfaces and blebs are seen
• increase in the percentage of cells with flattened or doughnut (34.5%) shape compared to controls
• red cells are 75 - 80% the size of wild-type cells
• increase in the percentage of acanthocytes or cells with teardrop shape (6.2%) compared to controls

Mouse Models of Human Disease
OMIM ID Ref(s)
Alpha-Thalassemia 604131 J:123943




Genotype
MGI:3720085
ht3
Allelic
Composition
Hbab3(th)/Hba+
Genetic
Background
involves: 101 * SEC
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hbab3(th) mutation (0 available); any Hba mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• display a diminished fast band, higher than normal solubility, and precipitates containing few, large, found aggregates of crystals




Genotype
MGI:3720087
ht4
Allelic
Composition
Hbab3(th)/Hba+
Genetic
Background
involves: C57BL6J * SEC
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hbab3(th) mutation (0 available); any Hba mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• fewer than expected heterozygous mice are found at weaning (9% compared to the expected 50%)

Mouse Models of Human Disease
OMIM ID Ref(s)
Alpha-Thalassemia 604131 J:32654




Genotype
MGI:3720088
ht5
Allelic
Composition
Hbab3(th)/Hba+
Genetic
Background
SEC-Hbab3(th)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hbab3(th) mutation (0 available); any Hba mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• many pups die between birth and weaning

hematopoietic system
• at E13.5 - E15.5, eosinophilic inclusions are seen in liver derived erythrocytes
• however, no abnormalities are seen in yolk-sac derived nucleated erythrocytes

growth/size/body
• newborn pups are smaller than wild-type littermates
• reduced in heterozygous adults to 18.77 +/- 0.59g compared to 23.79 +/- 0.39g in wild-type mice

Mouse Models of Human Disease
OMIM ID Ref(s)
Alpha-Thalassemia 604131 J:6452





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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory