All Phenotypes Hba<b3(th)> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Hba^b3(th)
27HB deletion, Oak Ridge
MGI:2677681

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hba^b3(th)/Hba^b3(th)	SEC-Hba^b3(th)	MGI:3720089
ht2	Hba^b3(th)/Hba⁺	either: (involves: 101 * SEC) or (involves: 101 * C57BL * SEC)	MGI:3720086
ht3	Hba^b3(th)/Hba⁺	involves: 101 * SEC	MGI:3720085
ht4	Hba^b3(th)/Hba⁺	involves: C57BL/6J * SEC	MGI:3720087
ht5	Hba^b3(th)/Hba⁺	SEC-Hba^b3(th)	MGI:3720088

Allelic Composition	Hba^b3(th)/Hba^b3(th)
Genetic Background	SEC-Hba^b3(th)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hba^b3(th) mutation (0 available); any Hba mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, incomplete penetrance ( J:6452 )

• most embryos appear to die between E.5. and E6.5

embryo

embryonic growth retardation ( J:6452 )

• at 86h post mating most homozygous embryos are still in the morula stage while wild-type littermates have reached the blastocyst stage

• at E5.5 some embryos remain in the late blastocyst stage and these have pycnotic cells in the trophectoderm

trophectoderm cell degeneration ( J:6452 )

• at E5.5 some embryos remain in the late blastocyst stage and these have pycnotic cells in the trophectoderm

growth/size/body

embryonic growth retardation ( J:6452 )

• at 86h post mating most homozygous embryos are still in the morula stage while wild-type littermates have reached the blastocyst stage

• at E5.5 some embryos remain in the late blastocyst stage and these have pycnotic cells in the trophectoderm

Allelic Composition	Hba^b3(th)/Hba⁺
Genetic Background	either: (involves: 101 * SEC) or (involves: 101 * C57BL * SEC)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hba^b3(th) mutation (0 available); any Hba mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

hypochromic microcytic anemia ( J:123943 )

increased erythrocyte cell number ( J:123943 )

decreased hematocrit ( J:123943 )

decreased hemoglobin content ( J:123943 )

decreased mean corpuscular hemoglobin ( J:123943 )

decreased mean corpuscular volume ( J:123943 )

• reduced mean cell volume despite increased red cell numbers

anisocytosis ( J:123943 )

acanthocytosis ( J:86011 )

anisopoikilocytosis ( J:86011 )

• red cells of irregular size and shape with pitted surfaces and blebs are seen

dacryocytosis ( J:86011 )

leptocytosis ( J:86011 )

• increase in the percentage of cells with flattened or doughnut (34.5%) shape compared to controls

microcytosis ( J:123943 )

• red cells are 75 - 80% the size of wild-type cells

poikilocytosis ( J:86011 )

• increase in the percentage of acanthocytes or cells with teardrop shape (6.2%) compared to controls

reticulocytosis ( J:123943 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
alpha thalassemia		DOID:1099	OMIM:604131	J:123943

Allelic Composition	Hba^b3(th)/Hba⁺
Genetic Background	involves: 101 * SEC

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hba^b3(th) mutation (0 available); any Hba mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal hemoglobin ( J:5686 )

• display a diminished fast band, higher than normal solubility, and precipitates containing few, large, found aggregates of crystals

Allelic Composition	Hba^b3(th)/Hba⁺
Genetic Background	involves: C57BL/6J * SEC

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hba^b3(th) mutation (0 available); any Hba mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality ( J:32654 )

• fewer than expected heterozygous mice are found at weaning (9% compared to the expected 50%)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
alpha thalassemia		DOID:1099	OMIM:604131	J:32654

Allelic Composition	Hba^b3(th)/Hba⁺
Genetic Background	SEC-Hba^b3(th)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hba^b3(th) mutation (0 available); any Hba mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:6452 )

• many pups die between birth and weaning

hematopoietic system

abnormal fetal derived definitive erythrocyte morphology ( J:6452 )

• at E13.5 - E15.5, eosinophilic inclusions are seen in liver derived erythrocytes

• however, no abnormalities are seen in yolk-sac derived nucleated erythrocytes

growth/size/body

decreased birth body size ( J:6452 )

• newborn pups are smaller than wild-type littermates

decreased body weight ( J:6452 )

• reduced in heterozygous adults to 18.77 +/- 0.59g compared to 23.79 +/- 0.39g in wild-type mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
alpha thalassemia		DOID:1099	OMIM:604131	J:6452

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