Phenotypes associated with this allele
Allelic Composition |
Vhltm1.1Lss/Vhl+
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Genetic Background |
involves: A/J |
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vhltm1.1Lss mutation
(0 available);
any
Vhl mutation
(16 available)
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liver/biliary system
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• 66% showed hepatic vascular lesions on a A/J genetic background
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Allelic Composition |
Vhltm1.1Lss/Vhl+
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Genetic Background |
involves: BALB/c |
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vhltm1.1Lss mutation
(0 available);
any
Vhl mutation
(16 available)
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neoplasm
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• 88% showed hepatic hemangiomas by 18 months of age, on a BALB/c genetic background
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liver/biliary system
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• 88% showed hepatic hemangiomas by 18 months of age, on a BALB/c genetic background
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vhltm1.1Lss mutation
(0 available);
any
Vhl mutation
(16 available)
Vhltm1Lss mutation
(0 available);
any
Vhl mutation
(16 available)
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neoplasm
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• observed in 18% of mice between 4 and 12 months of age, putatively due to sporadic LOH
• smaller than those observed in Vhlhtm1Lss/ Vhlhtm1.1Lss;Tg(ACTB-cre)1Tes mice
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reproductive system
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• 2-fold reduction in sperm count relative to wild-type
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liver/biliary system
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• observed in 18% of mice between 4 and 12 months of age, putatively due to sporadic LOH
• smaller than those observed in Vhlhtm1Lss/ Vhlhtm1.1Lss;Tg(ACTB-cre)1Tes mice
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cellular
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• 2-fold reduction in sperm count relative to wild-type
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CAG-cre/Esr1*)1Lbe mutation
(0 available)
Vhltm1.1Lss mutation
(0 available);
any
Vhl mutation
(16 available)
Vhltm1Lss mutation
(0 available);
any
Vhl mutation
(16 available)
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mortality/aging
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• all embryos of pregnant females injected with 2 mg of tamoxifen at E10.5 to inactive Vhlh during mid-gestational stage, die between E14.5 and E15.5
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growth/size/body
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• embryos of pregnant females injected with tamoxifen at E10.5 are smaller than controls
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cardiovascular system
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• treatment of pregnant females at E10.5 with tamoxifen results in abnormal vasculature and dilated blood vessels in the body of E14.7 embryos
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• dilated vessels are frequently seen after tamoxifen treatment
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• treatment of pregnant females at E10.5 with tamoxifen results in impaired blood circulation in the yolk sac of E14.7 embryos
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• treatment of pregnant females at E10.5 with tamoxifen results in hemorrhage in the dorsolateral region of embryos at E14.5
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cellular
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• at 24 hrs after bilateral renal ischemia-reperfusion injury (IRI), tamoxifen-treated mice exhibit significantly fewer TUNEL+ cells in the proximal tubules relative to tamoxifen-treated control mice
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• treatment of pregnant females at E10.5 with tamoxifen results in extensive embryo necrosis
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• treatment of pregnant females at E10.5 with tamoxifen results in focal necrosis in the liver or E14.5 embryos
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embryo
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• treatment of pregnant females at E10.5 with tamoxifen results in impaired blood circulation in the yolk sac of E14.7 embryos
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• treatment of pregnant females at E10.5 with tamoxifen results in extensive embryo necrosis
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• embryos of pregnant females injected with tamoxifen at E10.5 are smaller than controls
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• when pregnant females are injected with tamoxifen at E10.5, frequently observe dilated blood vessels and spongiotriophoblast cells in the labyrinthine layer
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• dilated vessels are frequently seen after tamoxifen treatment
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• thickness of the labyrinthine layer is reduced when pregnant females are injected with tamoxifen at E10.5
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liver/biliary system
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• treatment of pregnant females at E10.5 with tamoxifen results in focal necrosis in the liver or E14.5 embryos
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integument
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• seen in embryos of pregnant females injected with tamoxifen at E10.5
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homeostasis/metabolism
renal/urinary system
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• at 24 hrs after bilateral renal ischemia-reperfusion injury (IRI), tamoxifen-treated mice exhibit significantly fewer TUNEL+ cells in the proximal tubules relative to tamoxifen-treated control mice
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• at 24 hrs after bilateral renal IRI, tamoxifen-treated mice (0.36mg/g body weight injected i.p. one wk prior to IRI) exhibit better preservation of renal function and significantly lower tubular injury scores than tamoxifen-treated control mice (2.40 +/- 0.08 and 0.90 +/- 0.12, respectively), consistent with reduced proximal tubular injury, near absence of TUNEL+ cells, and milder tubular epithelial degeneration
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(ACTB-cre)1Tes mutation
(0 available)
Vhltm1.1Lss mutation
(0 available);
any
Vhl mutation
(16 available)
Vhltm1Lss mutation
(0 available);
any
Vhl mutation
(16 available)
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mortality/aging
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• mice began to die after 3 months of age
• 50% mortalitiy exhibited by 7 months of age
• 90% mortalitiy by 1 year of age
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reproductive system
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• 30-fold reduction in sperm count relative to wild-type
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• abnormal sperm maturation with multinucleated giant cells
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• enlarged blood vessels in the connective tissue surrounding the tubules
• tubule atrophy and collapse
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neoplasm
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• all mice displayed grossly visible hemangiomas by 1 year of age
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cardiovascular system
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• frequent angiectasis in the liver and with lesser penetrance in the kidneys
• increased vasculature of the pancreas
• no vascular lesions observed in the brain, ovary, or adrenal glands
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• limited new blood vessel formation in the liver
• angiogenesis observed the cardiac muscle of 8 of 10 mice examined
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liver/biliary system
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• livers were irregularly shaped and had vascular lesions containing large, thin-walled vessels filled with blood
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• all mice displayed grossly visible hemangiomas by 1 year of age
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endocrine/exocrine glands
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• enlarged blood vessels in the connective tissue surrounding the tubules
• tubule atrophy and collapse
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cellular
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• 30-fold reduction in sperm count relative to wild-type
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• abnormal sperm maturation with multinucleated giant cells
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