Analysis Tools
mortality/aging
|
• no homozygotes found at E10 or later
|
cardiovascular system
|
• no heart tube at E9-9.5
|
absent heart
(
J:85894
)
|
• no heart at E9-9.5
|
embryo
|
• absence of branchial arches and lack of dorsal root ganglia indicates abnormal neural crest specification and/or migration
|
|
• embryos have not turned at E9-9.5
|
|
• E7.5 endoderm cells 40% smaller than normal
|
|
• posterior growth halted by E9-9.5
• no significant development posterior to the allantois
|
|
• by E7 embryos are smaller than normal
• significantly smaller in length by E8.0
|
|
• no branchial arches at E9-9.5
|
|
• presomitic mesoderm swollen at E9-9.5
|
|
• very small head folds at E8.0
• however, head folds are fused at E9.5
|
|
• no visible somites or posterior mesoderm at E8.0
• still no somites at E8.5, although a presomitic mesoderm is present
• somites are absent are E9.0-E9.5
|
|
• small allantois at E8.0 growing larger through E9-9.5 when it comes in contact with placenta but shows no vascularization
|
|
• at E8.0
|
growth/size/body
|
• by E7 embryos are smaller than normal
• significantly smaller in length by E8.0
|
|
• at E8.5 the head region is less developed, resembling a small compact mass
• the head has developed normally to some extent by E9.5
|
nervous system
|
• absence of forebrain at E9.5
• however, development of the mid- and hindbrain is relatively normal
|
|
• no dorsal root ganglia at E9-9.5
|
craniofacial
|
• no branchial arches at E9-9.5
|
vision/eye
anophthalmia
(
J:85894
)
|
• absence of eyes at E9.5
|
cellular
|
• absence of branchial arches and lack of dorsal root ganglia indicates abnormal neural crest specification and/or migration
|
