About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Pdpk1tm1.2Mlw
targeted mutation 1.2, Margaret A Lawlor
MGI:2677462
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Pdpk1tm1.2Mlw/Pdpk1tm1.2Mlw involves: BALB/c MGI:2677568
ht2
Pdpk1tm1Mlw/Pdpk1tm1.2Mlw involves: BALB/c MGI:2677556


Genotype
MGI:2677568
hm1
Allelic
Composition
Pdpk1tm1.2Mlw/Pdpk1tm1.2Mlw
Genetic
Background
involves: BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdpk1tm1.2Mlw mutation (0 available); any Pdpk1 mutation (118 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• no homozygotes found at E10 or later

cardiovascular system
• no heart tube at E9-9.5
• no heart at E9-9.5

embryo
• embryos have not turned at E9-9.5
• E7.5 endoderm cells 40% smaller than normal
• posterior growth halted by E9-9.5
• no significant development posterior to the allantois
• by E7 embryos are smaller than normal
• significantly smaller in length by E8.0
• no branchial arches at E9-9.5
• presomitic mesoderm swollen at E9-9.5
• very small head folds at E8.0
• however, head folds are fused at E9.5
• no visible somites or posterior mesoderm at E8.0
• still no somites at E8.5, although a presomitic mesoderm is present
• somites are absent are E9.0-E9.5
• absence of branchial arches and lack of dorsal root ganglia indicates abnormal neural crest specification and/or migration
• small allantois at E8.0 growing larger through E9-9.5 when it comes in contact with placenta but shows no vascularization
• at E8.0

growth/size/body
• by E7 embryos are smaller than normal
• significantly smaller in length by E8.0
• at E8.5 the head region is less developed, resembling a small compact mass
• the head has developed normally to some extent by E9.5

nervous system
• absence of forebrain at E9.5
• however, development of the mid- and hindbrain is relatively normal
• no dorsal root ganglia at E9-9.5

craniofacial
• no branchial arches at E9-9.5

vision/eye
• absence of eyes at E9.5




Genotype
MGI:2677556
ht2
Allelic
Composition
Pdpk1tm1Mlw/Pdpk1tm1.2Mlw
Genetic
Background
involves: BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdpk1tm1.2Mlw mutation (0 available); any Pdpk1 mutation (118 available)
Pdpk1tm1Mlw mutation (0 available); any Pdpk1 mutation (118 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• homozygotes born at 25% lower ratio than expected

growth/size/body
• males about 45-50% smaller at birth
• females about 35% smaller at birth
• kidney, pancreas, spleen, adrenal gland all 50% smaller in size
• due to smaller cells





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/22/2016
MGI 6.04
The Jackson Laboratory