Mouse Genome Informatics
hm1
    Pdpk1tm1.2Mlw/Pdpk1tm1.2Mlw
involves: BALB/c
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• no homozygotes found at E10 or later

cardiovascular system
• no heart tube at E9-9.5
• no heart at E9-9.5

embryogenesis
• embryos have not turned at E9-9.5
• by E7 embryos are smaller than normal
• becoming significantly more noticeable with time
• posterior growth halted by E9-9.5
• no branchial arches at E9-9.5
• defined embryonic and extraembryonic segments at E7
• E7.5 endoderm cells 40% smaller than normal
• very small head folds at E8
• head folds fused at E9.5
• no visible somites or posterior mesoderm at E8
• presomitic mesoderm only at E8.5
• presomitic mesoderm swollen at E9-9.5
• absence of neural crest derived tissues
• small allantois at E7 growing larger through E9-9.5 when it comes in contact with placenta but shows no vascularization

growth/size
• by E7 embryos are smaller than normal
• becoming significantly more noticeable with time
• posterior growth halted by E9-9.5
• no branchial arches at E9-9.5

nervous system
• very small head folds at E8
• head folds fused at E9.5
• absence of forebrain at E9.5
• no dorsal root ganglia at E9-9.5

vision/eye
• absence of eyes at E9.5


Mouse Genome Informatics
ht2
    Pdpk1tm1Mlw/Pdpk1tm1.2Mlw
involves: BALB/c
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• homozygotes born at 25% lower ratio than expected

growth/size
• males about 45-50% smaller at birth
• females about 35% smaller at birth
• kidney, pancreas, spleen, adrenal all 50% smaller in size
• due to smaller cells