About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Vpreb1atm1Shim
targeted mutation 1, Takeyuki Shimizu
MGI:2677163
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Igll1tm1Shim/Igll1tm1Shim
Vpreb1atm1Shim/Vpreb1atm1Shim
Vpreb1btm1Shim/Vpreb1btm1Shim 		involves: 129P2/OlaHsd * C57BL/6 MGI:2677211


Genotype
MGI:2677211
cx1
Allelic
Composition		 Igll1tm1Shim/Igll1tm1Shim
Vpreb1atm1Shim/Vpreb1atm1Shim
Vpreb1btm1Shim/Vpreb1btm1Shim
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igll1tm1Shim mutation (0 available); any Igll1 mutation (16 available)
Vpreb1atm1Shim mutation (0 available); any Vpreb1a mutation (24 available)
Vpreb1btm1Shim mutation (0 available); any Vpreb1b mutation (8 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal B cell differentiation ( J:76947 )
• cultured bone marrow cells do not express Vpreb or Igl-5 either on the cell surface or in the cytoplasm
• numbers of nucleated bone marrow cells reduced
• no impairment of transition from immature to mature B cells
• no impairment of transition from pre-BII to immature B cells
• impaired transition from pre-BI to pre-BII
decreased immature B cell number ( J:76947 )
• reduced numbers of immature B cells
increased late pro-B cell number ( J:76947 )
• together with pre-BI cells, numbers increase 2 fold in cultured bone marrow cells
decreased mature B cell number ( J:76947 )
• reduced numbers of mature B cells
decreased B-1a cell number ( J:76947 )
• reduced numbers of B1-a cells at 10 days of age
decreased pre-B cell number ( J:76947 )
• pre-BII cells are severely decreased in numbers (25 fold at 3 weeks and 12 fold at 8-9 weeks)
• 7 fold decrease in large cells and 15 fold decrease in small cells

immune system
immune system phenotype ( J:76947 )
N
• serum levels of IgM were normal
abnormal B cell differentiation ( J:76947 )
• cultured bone marrow cells do not express Vpreb or Igl-5 either on the cell surface or in the cytoplasm
• numbers of nucleated bone marrow cells reduced
• no impairment of transition from immature to mature B cells
• no impairment of transition from pre-BII to immature B cells
• impaired transition from pre-BI to pre-BII
decreased immature B cell number ( J:76947 )
• reduced numbers of immature B cells
increased late pro-B cell number ( J:76947 )
• together with pre-BI cells, numbers increase 2 fold in cultured bone marrow cells
decreased mature B cell number ( J:76947 )
• reduced numbers of mature B cells
decreased B-1a cell number ( J:76947 )
• reduced numbers of B1-a cells at 10 days of age
decreased pre-B cell number ( J:76947 )
• pre-BII cells are severely decreased in numbers (25 fold at 3 weeks and 12 fold at 8-9 weeks)
• 7 fold decrease in large cells and 15 fold decrease in small cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory