All Phenotypes Akt1<tm1Hem> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Akt1^tm1Hem/Akt1^tm1Hem	involves: 129P2/OlaHsd	MGI:3588771
hm2	Akt1^tm1Hem/Akt1^tm1Hem	involves: 129P2/OlaHsd * C57BL/6	MGI:2675234
cx3	Akt1^tm1Hem/Akt1⁺ Akt2^tm1Hem/Akt2^tm1Hem Akt3^tm1Hem/Akt3^tm1Hem	involves: 129P2/OlaHsd * C57BL/6	MGI:3691596
cx4	Akt1^tm1Hem/Akt1^tm1Hem Akt2^tm1Hem/Akt2^tm1Hem Akt3^tm1Hem/Akt3^tm1Hem	involves: 129P2/OlaHsd * C57BL/6	MGI:3691595

Allelic Composition	Akt1^tm1Hem/Akt1^tm1Hem
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akt1^tm1Hem mutation (0 available); any Akt1 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

thin hypodermis ( J:96826 )

• decreased hypodermis thickness

underdeveloped hair follicles ( J:96826 )

• follicular growth is delayed at P4, with skin displaying an increased proportion of underdeveloped hair follicles

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Structural abnormalities of E14 Akt1^tm1Hem/Akt1^tm1Hem mouse placenta

mortality/aging

postnatal lethality, incomplete penetrance ( J:85181 )

• about 40% of mutants are lost by 2-4 weeks after birth

• frequently, the majority of pups from homozygous intercross litters die within 10 days

embryo

abnormal placenta morphology ( J:85181 )

• placenta is not only small but also thin

abnormal placenta vasculature ( J:85181 )

• fetal placental vasculature is disordered with fewer, smaller and shorter vessels

• 52% decrease in total vessel length and 48% decrease in microvessel-covering area

• vascular branching is scarce

abnormal maternal decidual layer morphology ( J:85181 )

• the decidua is disproportionately decreased or missing in some mutant placentas

decreased spongiotrophoblast size ( J:85181 )

• the spongiotrophoblast of the placenta is smaller

decreased trophoblast glycogen cell number ( J:85181 )

• periodic acid Schiff's staining shows a reduction of glycogen-containing cells in the spongiotrophoblast

decreased placental labyrinth size ( J:85181 )

• the labyrinth of the placenta is smaller

small placenta ( J:85181 )

• severe hypotrophy of the placenta

decreased placenta weight ( J:85181 )

• placental weight is 24% lower than that of wild-type at E14.5

• while placenta weight increases from E14.5 to E16.5 in wild-type, in mutants, the weight of placenta does not change during this time period

abnormal placenta development ( J:85181 )

• placental hypotrophy with marked reduction of the decidual basalis and nearly complete loss of glycogen containing cells in the spongioblast

• decreased vascularization

growth/size/body

decreased body size ( J:85181 )

• mutants maintain small size from birth to adulthood

decreased body weight ( J:85181 )

• body weight of newborns is about 70% of wild-type littermates

postnatal growth retardation ( J:85181 )

• surviving mutants grow slowly after birth, with some extremely stunted and lean

decreased fetal size ( J:85181 )

• E14.5 fetuses are 20% smaller than wild-type

behavior/neurological

weakness ( J:85181 )

• newborns are weak

reproductive system

abnormal maternal decidual layer morphology ( J:85181 )

• the decidua is disproportionately decreased or missing in some mutant placentas

decreased litter size ( J:85181 )

integument

pallor ( J:85181 )

• newborns are pale

cardiovascular system

abnormal placenta vasculature ( J:85181 )

• fetal placental vasculature is disordered with fewer, smaller and shorter vessels

• 52% decrease in total vessel length and 48% decrease in microvessel-covering area

• vascular branching is scarce

Allelic Composition	Akt1^tm1Hem/Akt1⁺ Akt2^tm1Hem/Akt2^tm1Hem Akt3^tm1Hem/Akt3^tm1Hem
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akt1^tm1Hem mutation (0 available); any Akt1 mutation (34 available)
Akt2^tm1Hem mutation (0 available); any Akt2 mutation (51 available)
Akt3^tm1Hem mutation (0 available); any Akt3 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body size ( J:114675 )

• viable and fertile and showed no obvious defects except for a severe growth deficiency

decreased body weight ( J:114675 )

• body weight at the age of 12 weeks reduced around 40% of wild-type

Allelic Composition	Akt1^tm1Hem/Akt1^tm1Hem Akt2^tm1Hem/Akt2^tm1Hem Akt3^tm1Hem/Akt3^tm1Hem
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:114675 )

• no triple homozygous mice were obtained from appropriate crosses implying embryonic lethality

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