Phenotypes associated with this allele

• Allele Symbol: Fanca^tm1.1Wong
• Allele Name: targeted mutation 1.1, Jasmine C Y Wong
• Allele ID: MGI:2674095
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fanca^tm1.1Wong/Fanca^tm1.1Wong	involves: 129S6/SvEvTac	MGI:3047102
hm2	Fanca^tm1.1Wong/Fanca^tm1.1Wong	involves: C57BL/6	MGI:3047099
cx3	Faap20^tm1(KOMP)Mbp/Faap20^tm1(KOMP)Mbp Fanca^tm1.1Wong/Fanca^tm1.1Wong	involves: 129S6/SvEvTac * C57BL/6 * C57BL/6N	MGI:5691433

Genotype
MGI:3047102

hm1

• Allelic Composition: Fanca^tm1.1Wong/Fanca^tm1.1Wong
• Genetic Background: involves: 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

vision/eye phenotype ( J:85108 )

N • microphthalmia was not observed in mice on 129S6/SvEvTac genetic background

Genotype
MGI:3047099

hm2

• Allelic Composition: Fanca^tm1.1Wong/Fanca^tm1.1Wong
• Genetic Background: involves: C57BL/6

cellular

decreased germ cell number ( J:85108 )

• ~50% the number of germ cells as wild-type embryos at E11.5

• depletion due to impaired survival or proliferation rather than to impaired migration

abnormal cell physiology ( J:85108 )

• increased susceptibility of cultured bone marrow cells to mitomycin C (MMC), a DNA cross-linking agent

craniofacial

abnormal cranium morphology ( J:85108 )

• mostly involving dextral deviation of the rostrum

• Background Sensitivity: observed on a C57BL/6 genetic background in conjunction with microphthalmia

endocrine/exocrine glands

seminiferous tubule degeneration ( J:85108 )

♂ • Background Sensitivity: 68% were severely degenerated, on a C57BL/6 genetic background

decreased testis weight ( J:85108 )

♂ • Background Sensitivity: reduced testicular weight on a C57BL/6 genetic background relative to heterozygotes and homozygotes on a 129S6/SvEvTac genetic background

growth/size/body

embryonic growth retardation ( J:85108 )

• Background Sensitivity: observed on a C57BL/6 genetic background

decreased body weight ( J:85108 )

• Background Sensitivity: mice on a C57BL/6 genetic background weighed less at birth, indicating retarded prenatal growth

reproductive system

decreased germ cell number ( J:85108 )

• ~50% the number of germ cells as wild-type embryos at E11.5

• depletion due to impaired survival or proliferation rather than to impaired migration

seminiferous tubule degeneration ( J:85108 )

♂ • Background Sensitivity: 68% were severely degenerated, on a C57BL/6 genetic background

decreased testis weight ( J:85108 )

♂ • Background Sensitivity: reduced testicular weight on a C57BL/6 genetic background relative to heterozygotes and homozygotes on a 129S6/SvEvTac genetic background

reduced female fertility ( J:85108 )

♀

skeleton

abnormal cranium morphology ( J:85108 )

• mostly involving dextral deviation of the rostrum

• Background Sensitivity: observed on a C57BL/6 genetic background in conjunction with microphthalmia

vision/eye

microphthalmia ( J:85108 )

• often observed in conjunction with craniofacial abnormalities

• Background Sensitivity: exhibited by ~30% of mice on a C57BL/6 genetic background

embryo

embryonic growth retardation ( J:85108 )

• Background Sensitivity: observed on a C57BL/6 genetic background

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Fanconi anemia complementation group A		DOID:0111095	OMIM:227650	J:85108

Genotype
MGI:5691433

cx3

• Allelic Composition: Faap20^tm1(KOMP)Mbp/Faap20^tm1(KOMP)Mbp; Fanca^tm1.1Wong/Fanca^tm1.1Wong
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6N
• Cell Lines: DEPD00507_1_A09

hematopoietic system

abnormal hematopoietic system physiology ( J:224688 )

• hematopoietic stem cells show a defect in long-term multilineage reconstitution for myeloid, B, and T cells in lethally irradiated recipient mice that is no different from single homozygous Fanca^tm1.1Wong mice