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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Fancatm1Wong
targeted mutation 1, Jasmine C Y Wong
MGI:2674094
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Fancatm1Wong/Fancatm1Wong either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * CD-1) MGI:3047101
hm2
Fancatm1Wong/Fancatm1Wong either: 129S6/SvEvTac or C57BL/6 MGI:3047139
hm3
Fancatm1Wong/Fancatm1Wong involves: 129S6/SvEvTac MGI:3047126
hm4
Fancatm1Wong/Fancatm1Wong involves: C57BL/6 MGI:3047131


Genotype
MGI:3047101
hm1
Allelic
Composition
Fancatm1Wong/Fancatm1Wong
Genetic
Background
either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * CD-1)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fancatm1Wong mutation (0 available); any Fanca mutation (36 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
N
• while not statistically significant due to small sample size, tumors were observed in 33% of mice on a mixed genetic background involving 129S6/SvEvTac and CD1 and in 11.7% of mice on a 129S6/SvEvTac coisogenic background; whereas no tumors were observed in wild-type mice

endocrine/exocrine glands
• about 3% were severely degenerated, on a 129S6/SvEvTac genetic background

reproductive system
• about 3% were severely degenerated, on a 129S6/SvEvTac genetic background




Genotype
MGI:3047139
hm2
Allelic
Composition
Fancatm1Wong/Fancatm1Wong
Genetic
Background
either: 129S6/SvEvTac or C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fancatm1Wong mutation (0 available); any Fanca mutation (36 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• ovaries appeared hemorrhagic
• ovaries contained many cysts

reproductive system
• ovaries appeared hemorrhagic
• ovaries contained many cysts

cardiovascular system
• ovaries appeared hemorrhagic




Genotype
MGI:3047126
hm3
Allelic
Composition
Fancatm1Wong/Fancatm1Wong
Genetic
Background
involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fancatm1Wong mutation (0 available); any Fanca mutation (36 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• females exhibited premature reproductive senescence

reproductive system
• increased male germ cell apoptosis
• ~3% were severely degenerated, on a 129S6/SvEvTac genetic background
• ~2-fold smaller than those of heterozygotes on a 129S6/SvEvTac coisogenic background
• females exhibited premature reproductive senescence
• observed in both 129S6/SvEvTac and C57BL/6 genetic backgrounds, however a more severe depletion was observed in the C57BL/6 background
• a proportion of spermatocytes progressed through spermatogenesis to produce functional spermatozoa
• elevated frequency of mispaired meiotic chromosomes
• putatively due to a diminished population of primordial germ cells during migration into the genital ridge
• male fertility was not impaired

endocrine/exocrine glands
• ~3% were severely degenerated, on a 129S6/SvEvTac genetic background
• ~2-fold smaller than those of heterozygotes on a 129S6/SvEvTac coisogenic background

cellular
• increased male germ cell apoptosis




Genotype
MGI:3047131
hm4
Allelic
Composition
Fancatm1Wong/Fancatm1Wong
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fancatm1Wong mutation (0 available); any Fanca mutation (36 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial

endocrine/exocrine glands

growth/size/body
• Background Sensitivity: observed on a C57BL/6 genetic background
• observed on a C57BL/6 genetic background

reproductive system
• Background Sensitivity: observed in both 129S6/SvEvTac and C57BL/6 genetic backgrounds, however a more severe depletion was observed in the C57BL/6 background

skeleton

vision/eye
• often observed in conjunction with craniofacial abnormalities
• Background Sensitivity: exhibited on a C57BL/6 genetic background

Mouse Models of Human Disease
OMIM ID Ref(s)
Fanconi Anemia, Complementation Group A; FANCA 227650 J:85108





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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory