Mouse Genome Informatics
hm1
    Fancatm1Wong/Fancatm1Wong
either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * CD-1)
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
tumorigenesis
N
• while not statistically significant due to small sample size, tumors were observed in 33% of mice on a mixed genetic background involving 129S6/SvEvTac and CD1 and in 11.7% of mice on a 129S6/SvEvTac coisogenic background; whereas no tumors were observedin wild-type mice

endocrine/exocrine glands
• about 3% were severely degenerated, on a 129S6/SvEvTac genetic background

reproductive system
• about 3% were severely degenerated, on a 129S6/SvEvTac genetic background


Mouse Genome Informatics
hm2
    Fancatm1Wong/Fancatm1Wong
either: 129S6/SvEvTac or C57BL/6
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• ovaries appeared hemorrhagic
• ovaries contained many cysts

reproductive system
• ovaries appeared hemorrhagic
• ovaries contained many cysts

cardiovascular system
• ovaries appeared hemorrhagic


Mouse Genome Informatics
hm3
    Fancatm1Wong/Fancatm1Wong
involves: 129S6/SvEvTac
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• females exhibited premature reproductive senescence

reproductive system
• increased male germ cell apoptosis
• ~3% were severely degenerated, on a 129S6/SvEvTac genetic background
• ~2-fold smaller than those of heterozygotes on a 129S6/SvEvTac coisogenic background
• females exhibited premature reproductive senescence
• observed in both 129S6/SvEvTac and C57BL/6 genetic backgrounds, however a more severe depletion was observed in the C57BL/6 background
• a proportion of spermatocytes progressed through spermatogenesis to produce functional spermatozoa
• elevated frequency of mispaired meiotic chromosomes
• putatively due to a diminished population of primordial germ cells during migration into the genital ridge
• male fertility was not impaired

endocrine/exocrine glands
• ~3% were severely degenerated, on a 129S6/SvEvTac genetic background
• ~2-fold smaller than those of heterozygotes on a 129S6/SvEvTac coisogenic background

cellular
• increased male germ cell apoptosis


Mouse Genome Informatics
hm4
    Fancatm1Wong/Fancatm1Wong
involves: C57BL/6
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial

endocrine/exocrine glands

growth/size/body
• Background Sensitivity: observed on a C57BL/6 genetic background
• observed on a C57BL/6 genetic background

reproductive system
• Background Sensitivity: observed in both 129S6/SvEvTac and C57BL/6 genetic backgrounds, however a more severe depletion was observed in the C57BL/6 background

skeleton

vision/eye
• often observed in conjunction with craniofacial abnormalities
• Background Sensitivity: exhibited on a C57BL/6 genetic background

Mouse Models of Human Disease
OMIM IDRef(s)
Fanconi Anemia, Complementation Group A; FANCA 227650 J:85108