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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Serpinb6atm1.1Pib
targeted mutation 1.1, Phillip I Bird
MGI:2673997
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Serpinb6atm1.1Pib/Serpinb6atm1.1Pib involves: C57BL/6 MGI:3720028


Genotype
MGI:3720028
hm1
Allelic
Composition
Serpinb6atm1.1Pib/Serpinb6atm1.1Pib
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Serpinb6atm1.1Pib mutation (0 available); any Serpinb6a mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• homozygous mice develop normally and are fertile, with no abnormal pathology or increased sensitivity to cerebral ischemia
• no perturbations in leukocyte development or numbers
• recruitment of leukocytes to the peritoneal cavity is normal
• mutant mice are equally susceptible as control mice to systemic Candida albicans infection
• increased levels of a related inhibitor Serpinb1 (monocyte/neutrophil elastase inhibitor) in the tissues of targeted mice suggests that compensation by other serpins reduces the impact of Serpinb6 deficiency in these animals





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory