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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Egfrtm2(EGFR)Wag
targeted mutation 2, Erwin F Wagner
MGI:2673586
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Egfrtm2(EGFR)Wag/Egfrtm2(EGFR)Wag involves: 129 MGI:2673652
hm2
Egfrtm2(EGFR)Wag/Egfrtm2(EGFR)Wag involves: 129/Sv * C57BL/6 MGI:2673649
ht3
Egfrtm1Wag/Egfrtm2(EGFR)Wag involves: 129 MGI:2673651
ht4
Egfrtm1Wag/Egfrtm2(EGFR)Wag involves: 129/Sv * C57BL/6 MGI:2673650


Genotype
MGI:2673652
hm1
Allelic
Composition
Egfrtm2(EGFR)Wag/Egfrtm2(EGFR)Wag
Genetic
Background
involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egfrtm2(EGFR)Wag mutation (0 available); any Egfr mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:2673649
hm2
Allelic
Composition
Egfrtm2(EGFR)Wag/Egfrtm2(EGFR)Wag
Genetic
Background
involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egfrtm2(EGFR)Wag mutation (0 available); any Egfr mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
muscle

mortality/aging
• increased lethality prior to 6 months of age due to cardiac hypertrophy
• incomplete penetrance, 7% of homozygous mutant mice were born alive

cardiovascular system
• contributing to increased lethality
• apparent 3 weeks after birth in some mice

growth/size/body

skeleton
• accelerated osteoblast differentiation
• accelerated chondrocyte differentiation

nervous system
N
• in contrast to null mice, normal architecture and morphology was observed in various sections of the brain including the frontal cortex, hippocampus, olfactory bulb, thalamus, and cerebellum

integument
• by 5 to 7 months of age due to progressive degeneration of hair follicles
• progressive degeneration and inflammation led to the loss of most follicles over time, leading to baldness by 5 to 7 months of age

cellular
• accelerated osteoblast differentiation




Genotype
MGI:2673651
ht3
Allelic
Composition
Egfrtm1Wag/Egfrtm2(EGFR)Wag
Genetic
Background
involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egfrtm1Wag mutation (0 available); any Egfr mutation (14 available)
Egfrtm2(EGFR)Wag mutation (0 available); any Egfr mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:2673650
ht4
Allelic
Composition
Egfrtm1Wag/Egfrtm2(EGFR)Wag
Genetic
Background
involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egfrtm1Wag mutation (0 available); any Egfr mutation (14 available)
Egfrtm2(EGFR)Wag mutation (0 available); any Egfr mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/14/2020
MGI 6.14
The Jackson Laboratory