Phenotypes associated with this allele

• Allele Symbol: Mif^tm1Gfr
• Allele Name: targeted mutation 1, G Fingerle-Rowson
• Allele ID: MGI:2673280
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mif^tm1Gfr/Mif^tm1Gfr	C57BL/6-Mif^tm1Gfr	MGI:2673287

Genotype
MGI:2673287

hm1

• Allelic Composition: Mif^tm1Gfr/Mif^tm1Gfr
• Genetic Background: C57BL/6-Mif^tm1Gfr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased incidence of tumors by chemical induction ( J:147772 )

• mice treated with benzo[alpha]pyrene-induced develop more skin tumors compared to similarly treated wild-type mice

• benzo[alpha]pyrene-treated mice develop more benign tumors relative to malignant tumors than in similarly treated wild-type mice

increased fibrosarcoma incidence ( J:84791 )

• fibrosarcomas induced by benzo[alpha]pyrene were smaller and had a lower mitotic index than those observed in wild-type mice

cellular

decreased mitotic index ( J:84791 )

• mitotic index of tumors is lower than in tumors induced in wild-type

decreased fibroblast proliferation ( J:147772 )

• mouse embryonic fibroblasts exhibit reduced proliferation compared to wild-type cells

• mouse embryonic fibroblasts transformed retrovirally with Ras produce fewer and smaller colonies than similarly treated wild-type cells

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:147772 )

• mice treated with benzo[alpha]pyrene-induced develop more skin tumors compared to similarly treated wild-type mice

• benzo[alpha]pyrene-treated mice develop more benign tumors relative to malignant tumors than in similarly treated wild-type mice