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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Rrm2btm1Ynak
targeted mutation 1, Yusuke Nakamura
MGI:2672883
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Rrm2btm1Ynak/Rrm2btm1Ynak involves: 129 * C57BL/6J MGI:2672952


Genotype
MGI:2672952
hm1
Allelic
Composition
Rrm2btm1Ynak/Rrm2btm1Ynak
Genetic
Background
involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rrm2btm1Ynak mutation (0 available); any Rrm2b mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• most mice died from severe kidney failure between 11 and 12 weeks of age
• no mice survived past 14 weeks of age

cardiovascular system
• cornary artery contained hyaline deposits
• cardiac muscle appeared fibrotic

endocrine/exocrine glands
• submandibular gland was atrophic and had reduced numbers of secretory vesicles
• reduced area containing lymphocytes

growth/size/body
• beginning at 6 weeks of age

hematopoietic system
• reduced area containing lymphocytes
• reduced area containing lymphocytes

homeostasis/metabolism
• elevated creatine level
• elevated blood urea nitrogen level
• reduced concentration of albumin in the serum
• detectable as early as 4 weeks of age

immune system
• reduced area containing lymphocytes
• reduced area containing lymphocytes
• reduced area containing lymphocytes

liver/biliary system
• hepatic tissue was atrophic around the central vein but normal around Grison's sheath

muscle
• skeletal muscle was systemically atrophic

renal/urinary system
• detectable as early as 4 weeks of age
• the spontaneous mutation frequency of the kidney was significantly higher than that of wild-type at 6 weeks of age, putatively due to attenuation of dNTP pools and a resulting impairment of DNA repair
• increased apoptosis of renal cells

nervous system
• vacuolations in sciatic nerve fibers

digestive/alimentary system
• submandibular gland was atrophic and had reduced numbers of secretory vesicles

cellular
• increased apoptosis of renal cells





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory