Phenotypes associated with this allele

• Allele Symbol: Bcl2l1^tm1Cant
• Allele Name: targeted mutation 1, Harvey Cantor
• Allele ID: MGI:2672833
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Bcl2l1^tm1Cant/Bcl2l1^tm1Cant	involves: 129S6/SvEvTac	MGI:2673205

Genotype
MGI:2673205

hm1

• Allelic Composition: Bcl2l1^tm1Cant/Bcl2l1^tm1Cant
• Genetic Background: involves: 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased memory T cell number ( J:77507 )

• levels of memory T cells, based on CD62L and CD44 expression, are decreased by about 50%

abnormal T cell physiology ( J:77507 )

• T cells display defective cytokine responses to CD28-dependent costimulatory signals

• colligation of CD3/CD28 does not enhance progression of T cells into G2/M as observed in wild-type T cells

decreased T cell proliferation ( J:77507 )

• T cells show defective proliferative responses to CD28-dependent costimulatory signals in vitro

• in vitro proliferative response of T cells to CD3/CD28 coligation is reduced by more than 80%

• in vivo proliferative response of T cells to the superantigen staphylococcal enterotoxin A (SEA) is reduced by about 60%

abnormal memory T cell physiology ( J:77507 )

• T cells display impaired memory responses to proteolipid protein peptide (PLP)

decreased interleukin-2 secretion ( J:77507 )

• T cells display reduced IL-2 production in response to CD28 ligation

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:77507 )

• mutants do not develop proteolipid protein peptide (PLP)-induced experimental autoimmune encephalomyelitis

hematopoietic system

decreased memory T cell number ( J:77507 )

• levels of memory T cells, based on CD62L and CD44 expression, are decreased by about 50%

abnormal T cell physiology ( J:77507 )

• T cells display defective cytokine responses to CD28-dependent costimulatory signals

• colligation of CD3/CD28 does not enhance progression of T cells into G2/M as observed in wild-type T cells

decreased T cell proliferation ( J:77507 )

• T cells show defective proliferative responses to CD28-dependent costimulatory signals in vitro

• in vitro proliferative response of T cells to CD3/CD28 coligation is reduced by more than 80%

• in vivo proliferative response of T cells to the superantigen staphylococcal enterotoxin A (SEA) is reduced by about 60%

abnormal memory T cell physiology ( J:77507 )

• T cells display impaired memory responses to proteolipid protein peptide (PLP)

cellular

decreased T cell proliferation ( J:77507 )

• T cells show defective proliferative responses to CD28-dependent costimulatory signals in vitro

• in vitro proliferative response of T cells to CD3/CD28 coligation is reduced by more than 80%

• in vivo proliferative response of T cells to the superantigen staphylococcal enterotoxin A (SEA) is reduced by about 60%