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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Smotm1.1Pab
targeted mutation 1.1, Philip A Beachy
MGI:2672132
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Smotm1.1Pab/Smotm1.1Pab Not Specified MGI:3720038


Genotype
MGI:3720038
hm1
Allelic
Composition
Smotm1.1Pab/Smotm1.1Pab
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smotm1.1Pab mutation (0 available); any Smo mutation (39 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryo
• mandibular component of the first branchial arch is severely reduced
• mandibular component of the first branchial arch is fused in the midline
• at E9.5 mice have an abnormal trunk
• mutants exhibit a kink in the truck with dorsal instead of ventral curling of the tail, indicating defective embryonic turning
• small at E9.5
• midline fusion of the anterior lips of the cephalic neural plate and a poorly defined or absent midline groove at E8.5
• E8.25 mutants exhibit midline defects of the neural plate in the prospective forebrain

nervous system
• E8.25 mutants exhibit midline defects of the neural plate in the prospective forebrain

cardiovascular system
• at E9.5, the pericadial sac is enlarged

craniofacial
• mandibular component of the first branchial arch is severely reduced
• mandibular component of the first branchial arch is fused in the midline

growth/size/body
• small at E9.5

vision/eye
• incomplete separation of the bilateral evaginations that form the optic vesicles and by E8.5, the bilateral cup-like evaginations are replaced by a deep single evagination





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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory