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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Col2a1-cre)1Star
transgene insertion 1, Rene St-Arnaud
MGI:2671895
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Ilktm1Star/Ilktm1Star
Tg(Col2a1-cre)1Star/? 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:2671930
cn2
 		Panx3tm1c(KOMP)Wtsi/Panx3tm1c(KOMP)Wtsi
Tg(Col2a1-cre)1Star/0 		involves: C3H * C57BL/6 * C57BL/6J * C57BL/6N MGI:5788534
cn3
 		Runx1tm1.1Stkd/Runx1tm1.1Stkd
Runx2tm1Mjo/Runx2tm1Mjo
Tg(Col2a1-cre)1Star/0 		involves: C57BL/6 MGI:4440962
cn4
 		Runx1tm1.1Stkd/Runx1tm1.1Stkd
Tg(Col2a1-cre)1Star/0 		involves: C57BL/6 MGI:4440960
cn5
 		Runx2tm1.1Yyon/Runx2tm1.1Yyon
Tg(Col2a1-cre)1Star/0 		involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj MGI:5570667


Genotype
MGI:2671930
cn1
Allelic
Composition		 Ilktm1Star/Ilktm1Star
Tg(Col2a1-cre)1Star/?
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ilktm1Star mutation (1 available); any Ilk mutation (18 available)
Tg(Col2a1-cre)1Star mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
disproportionate dwarf ( J:84273 )
• newborn homozygotes were smaller than normal with the small size becoming more conspicuous with age
• forelimbs and hind limbs were shortened but not deformed

skeleton
chondrodystrophy ( J:84273 )
• moderate chondrodysplasia
• growth plate most affected in the proliferating zone
• Cyclin D1 expression reduced in the proliferating zone
• poor columnar organization
• chondrocytes more rounded
• chondrocyte differentiation unaffected
• apoptosis normal




Genotype
MGI:5788534
cn2
Allelic
Composition		 Panx3tm1c(KOMP)Wtsi/Panx3tm1c(KOMP)Wtsi
Tg(Col2a1-cre)1Star/0
Genetic
Background		 involves: C3H * C57BL/6 * C57BL/6J * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Panx3tm1c(KOMP)Wtsi mutation (0 available); any Panx3 mutation (21 available)
Tg(Col2a1-cre)1Star mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
decreased susceptibility to induced arthritis ( J:233542 )
• reduced severity and collagen staining in a DMM surgery model of induced osteoarthritis
osteophytes ( J:233542 )
• absent in a DMM surgery model of induced osteoarthritis

immune system
decreased susceptibility to induced arthritis ( J:233542 )
• reduced severity and collagen staining in a DMM surgery model of induced osteoarthritis




Genotype
MGI:4440962
cn3
Allelic
Composition		 Runx1tm1.1Stkd/Runx1tm1.1Stkd
Runx2tm1Mjo/Runx2tm1Mjo
Tg(Col2a1-cre)1Star/0
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Runx1tm1.1Stkd mutation (0 available); any Runx1 mutation (35 available)
Runx2tm1Mjo mutation (0 available); any Runx2 mutation (42 available)
Tg(Col2a1-cre)1Star mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
abnormal skeleton morphology ( J:158761 )
• newborn mice are indistinguishable from Runx2tm1Mjo homozygotes




Genotype
MGI:4440960
cn4
Allelic
Composition		 Runx1tm1.1Stkd/Runx1tm1.1Stkd
Tg(Col2a1-cre)1Star/0
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Runx1tm1.1Stkd mutation (0 available); any Runx1 mutation (35 available)
Tg(Col2a1-cre)1Star mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
skeleton phenotype ( J:158761 )
N
• mice exhibit normal skeletal morphology




Genotype
MGI:5570667
cn5
Allelic
Composition		 Runx2tm1.1Yyon/Runx2tm1.1Yyon
Tg(Col2a1-cre)1Star/0
Genetic
Background		 involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Runx2tm1.1Yyon mutation (0 available); any Runx2 mutation (42 available)
Tg(Col2a1-cre)1Star mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:210124 )
• due to difficulty breathing

skeleton
delayed bone ossification ( J:210124 )
• almost complete absence of mineralized tissue at E15.5
• however, ossification of the facial bone, skull bone and clavicle is normal
delayed endochondral bone ossification ( J:210124 )
• in newborn mice, including long bones and vertebrae

respiratory system
respiratory distress ( J:210124 )
• difficulty breathing at birth leading to death




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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory