Mouse Genome Informatics
cn1
    Sema3ftm1.1Ddg/Sema3ftm1.1Ddg
Tg(Syn1-cre)671Jxm/0

involves: C57BL/6 * CBA
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• the anterior limb of the anterior commissure is defasciculated
• 1 of 5 mutants exhibit improper development of the infrapyramidal tract
• most axons of the anterior limb of the anterior commissure cross the midline aberrantly and axons of the infrapyramidal tract extend beyond the stratum oriens of CA3
• however, no defects in stria terminalis targeting
• 1 of 5 mutants exhibit an infrapyramidal tract defect in which axons extend far into the stratum oriens of CA3, beyond the level at which they normally turn dorsally into the stratum radiatum
• the anterior limb of the anterior commissure is reduced and defasciculated
• although a small number of axons of the anterior commissure decussate properly, most axons cross the midline aberrantly as smaller tightly bundled fascicles

cellular
• the anterior limb of the anterior commissure is defasciculated


Mouse Genome Informatics
cn2
    Sema3ftm1.1Ddg/Sema3ftm1.2Ddg
Tg(Syn1-cre)671Jxm/0

involves: C57BL/6 * CBA
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• the anterior limb of the anterior commissure is defasciculated
• 2 of 3 mutants exhibit improper development of the infrapyramidal tract
• however, no defects in stria terminalis targeting
• most axons of the anterior limb of the anterior commissure cross the midline aberrantly and axons of the infrapyramidal tract extend beyond the stratum oriens of CA3
• 2 of 3 mutants exhibit an infrapyramidal tract defect in which axons extend far into the stratum oriens of CA3, beyond the level at which they normally turn dorsally into the stratum radiatum
• the anterior limb of the anterior commissure is reduced and defasciculated
• although a small number of axons of the anterior commissure decussate properly, most axons cross the midline aberrantly as smaller tightly bundled fascicles

cellular
• the anterior limb of the anterior commissure is defasciculated