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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Sema3ftm1.1Ddg
targeted mutation 1.1, David D Ginty
MGI:2670662
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Sema3ftm1.1Ddg/Sema3ftm1.1Ddg
Tg(Syn1-cre)671Jxm/0
involves: C57BL/6 * CBA MGI:2670683
cn2
Sema3ftm1.1Ddg/Sema3ftm1.2Ddg
Tg(Syn1-cre)671Jxm/0
involves: C57BL/6 * CBA MGI:2670688


Genotype
MGI:2670683
cn1
Allelic
Composition
Sema3ftm1.1Ddg/Sema3ftm1.1Ddg
Tg(Syn1-cre)671Jxm/0
Genetic
Background
involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sema3ftm1.1Ddg mutation (1 available); any Sema3f mutation (16 available)
Tg(Syn1-cre)671Jxm mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• the anterior limb of the anterior commissure is defasciculated
• 1 of 5 mutants exhibit improper development of the infrapyramidal tract
• most axons of the anterior limb of the anterior commissure cross the midline aberrantly and axons of the infrapyramidal tract extend beyond the stratum oriens of CA3
• however, no defects in stria terminalis targeting
• 1 of 5 mutants exhibit an infrapyramidal tract defect in which axons extend far into the stratum oriens of CA3, beyond the level at which they normally turn dorsally into the stratum radiatum
• the anterior limb of the anterior commissure is reduced and defasciculated
• although a small number of axons of the anterior commissure decussate properly, most axons cross the midline aberrantly as smaller tightly bundled fascicles

cellular
• the anterior limb of the anterior commissure is defasciculated




Genotype
MGI:2670688
cn2
Allelic
Composition
Sema3ftm1.1Ddg/Sema3ftm1.2Ddg
Tg(Syn1-cre)671Jxm/0
Genetic
Background
involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sema3ftm1.1Ddg mutation (1 available); any Sema3f mutation (16 available)
Sema3ftm1.2Ddg mutation (0 available); any Sema3f mutation (16 available)
Tg(Syn1-cre)671Jxm mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• the anterior limb of the anterior commissure is defasciculated
• 2 of 3 mutants exhibit improper development of the infrapyramidal tract
• most axons of the anterior limb of the anterior commissure cross the midline aberrantly and axons of the infrapyramidal tract extend beyond the stratum oriens of CA3
• however, no defects in stria terminalis targeting
• 2 of 3 mutants exhibit an infrapyramidal tract defect in which axons extend far into the stratum oriens of CA3, beyond the level at which they normally turn dorsally into the stratum radiatum
• the anterior limb of the anterior commissure is reduced and defasciculated
• although a small number of axons of the anterior commissure decussate properly, most axons cross the midline aberrantly as smaller tightly bundled fascicles

cellular
• the anterior limb of the anterior commissure is defasciculated





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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory