All Phenotypes Sema3f<tm1.1Ddg> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Sema3f^tm1.1Ddg
targeted mutation 1.1, David D Ginty
MGI:2670662

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Sema3f^tm1.1Ddg/Sema3f^tm1.1Ddg Tg(Syn1-cre)671Jxm/0	involves: C57BL/6 * CBA	MGI:2670683
cn2	Sema3f^tm1.1Ddg/Sema3f^tm1.2Ddg Tg(Syn1-cre)671Jxm/0	involves: C57BL/6 * CBA	MGI:2670688

Allelic Composition	Sema3f^tm1.1Ddg/Sema3f^tm1.1Ddg Tg(Syn1-cre)671Jxm/0
Genetic Background	involves: C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sema3f^tm1.1Ddg mutation (1 available); any Sema3f mutation (41 available)
Tg(Syn1-cre)671Jxm mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal axon fasciculation ( J:84687 )

• the anterior limb of the anterior commissure is defasciculated

abnormal hippocampus development ( J:84687 )

• 1 of 5 mutants exhibit improper development of the infrapyramidal tract

abnormal innervation ( J:84687 )

• most axons of the anterior limb of the anterior commissure cross the midline aberrantly and axons of the infrapyramidal tract extend beyond the stratum oriens of CA3

• however, no defects in stria terminalis targeting

abnormal nervous system tract morphology ( J:84687 )

• 1 of 5 mutants exhibit an infrapyramidal tract defect in which axons extend far into the stratum oriens of CA3, beyond the level at which they normally turn dorsally into the stratum radiatum

abnormal anterior commissure morphology ( J:84687 )

• the anterior limb of the anterior commissure is reduced and defasciculated

• although a small number of axons of the anterior commissure decussate properly, most axons cross the midline aberrantly as smaller tightly bundled fascicles

cellular

abnormal axon fasciculation ( J:84687 )

• the anterior limb of the anterior commissure is defasciculated

Allelic Composition	Sema3f^tm1.1Ddg/Sema3f^tm1.2Ddg Tg(Syn1-cre)671Jxm/0
Genetic Background	involves: C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sema3f^tm1.1Ddg mutation (1 available); any Sema3f mutation (41 available)
Sema3f^tm1.2Ddg mutation (0 available); any Sema3f mutation (41 available)
Tg(Syn1-cre)671Jxm mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal axon fasciculation ( J:84687 )

• the anterior limb of the anterior commissure is defasciculated

abnormal hippocampus development ( J:84687 )

• 2 of 3 mutants exhibit improper development of the infrapyramidal tract

abnormal innervation ( J:84687 )

• most axons of the anterior limb of the anterior commissure cross the midline aberrantly and axons of the infrapyramidal tract extend beyond the stratum oriens of CA3

• however, no defects in stria terminalis targeting

abnormal nervous system tract morphology ( J:84687 )

• 2 of 3 mutants exhibit an infrapyramidal tract defect in which axons extend far into the stratum oriens of CA3, beyond the level at which they normally turn dorsally into the stratum radiatum

abnormal anterior commissure morphology ( J:84687 )

• the anterior limb of the anterior commissure is reduced and defasciculated

• although a small number of axons of the anterior commissure decussate properly, most axons cross the midline aberrantly as smaller tightly bundled fascicles

cellular

abnormal axon fasciculation ( J:84687 )

• the anterior limb of the anterior commissure is defasciculated

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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