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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Sema3ftm1.1Ddg
targeted mutation 1.1, David D Ginty
MGI:2670662
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Sema3ftm1.1Ddg/Sema3ftm1.1Ddg
Tg(Syn1-cre)671Jxm/0
involves: C57BL/6 * CBA MGI:2670683
cn2
Sema3ftm1.1Ddg/Sema3ftm1.2Ddg
Tg(Syn1-cre)671Jxm/0
involves: C57BL/6 * CBA MGI:2670688


Genotype
MGI:2670683
cn1
Allelic
Composition
Sema3ftm1.1Ddg/Sema3ftm1.1Ddg
Tg(Syn1-cre)671Jxm/0
Genetic
Background
involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sema3ftm1.1Ddg mutation (1 available); any Sema3f mutation (15 available)
Tg(Syn1-cre)671Jxm mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• the anterior limb of the anterior commissure is defasciculated (J:84687)
• the anterior limb of the anterior commissure is defasciculated (J:84687)
• 1 of 5 mutants exhibit improper development of the infrapyramidal tract (J:84687)
• 1 of 5 mutants exhibit improper development of the infrapyramidal tract (J:84687)
• most axons of the anterior limb of the anterior commissure cross the midline aberrantly and axons of the infrapyramidal tract extend beyond the stratum oriens of CA3 (J:84687)
• however, no defects in stria terminalis targeting (J:84687)
• most axons of the anterior limb of the anterior commissure cross the midline aberrantly and axons of the infrapyramidal tract extend beyond the stratum oriens of CA3 (J:84687)
• however, no defects in stria terminalis targeting (J:84687)
• 1 of 5 mutants exhibit an infrapyramidal tract defect in which axons extend far into the stratum oriens of CA3, beyond the level at which they normally turn dorsally into the stratum radiatum (J:84687)
• 1 of 5 mutants exhibit an infrapyramidal tract defect in which axons extend far into the stratum oriens of CA3, beyond the level at which they normally turn dorsally into the stratum radiatum (J:84687)
• the anterior limb of the anterior commissure is reduced and defasciculated (J:84687)
• although a small number of axons of the anterior commissure decussate properly, most axons cross the midline aberrantly as smaller tightly bundled fascicles (J:84687)
• the anterior limb of the anterior commissure is reduced and defasciculated (J:84687)
• although a small number of axons of the anterior commissure decussate properly, most axons cross the midline aberrantly as smaller tightly bundled fascicles (J:84687)

cellular
• the anterior limb of the anterior commissure is defasciculated (J:84687)
• the anterior limb of the anterior commissure is defasciculated (J:84687)




Genotype
MGI:2670688
cn2
Allelic
Composition
Sema3ftm1.1Ddg/Sema3ftm1.2Ddg
Tg(Syn1-cre)671Jxm/0
Genetic
Background
involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sema3ftm1.1Ddg mutation (1 available); any Sema3f mutation (15 available)
Sema3ftm1.2Ddg mutation (0 available); any Sema3f mutation (15 available)
Tg(Syn1-cre)671Jxm mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• the anterior limb of the anterior commissure is defasciculated (J:84687)
• the anterior limb of the anterior commissure is defasciculated (J:84687)
• 2 of 3 mutants exhibit improper development of the infrapyramidal tract (J:84687)
• 2 of 3 mutants exhibit improper development of the infrapyramidal tract (J:84687)
• most axons of the anterior limb of the anterior commissure cross the midline aberrantly and axons of the infrapyramidal tract extend beyond the stratum oriens of CA3 (J:84687)
• however, no defects in stria terminalis targeting (J:84687)
• most axons of the anterior limb of the anterior commissure cross the midline aberrantly and axons of the infrapyramidal tract extend beyond the stratum oriens of CA3 (J:84687)
• however, no defects in stria terminalis targeting (J:84687)
• 2 of 3 mutants exhibit an infrapyramidal tract defect in which axons extend far into the stratum oriens of CA3, beyond the level at which they normally turn dorsally into the stratum radiatum (J:84687)
• 2 of 3 mutants exhibit an infrapyramidal tract defect in which axons extend far into the stratum oriens of CA3, beyond the level at which they normally turn dorsally into the stratum radiatum (J:84687)
• the anterior limb of the anterior commissure is reduced and defasciculated (J:84687)
• although a small number of axons of the anterior commissure decussate properly, most axons cross the midline aberrantly as smaller tightly bundled fascicles (J:84687)
• the anterior limb of the anterior commissure is reduced and defasciculated (J:84687)
• although a small number of axons of the anterior commissure decussate properly, most axons cross the midline aberrantly as smaller tightly bundled fascicles (J:84687)

cellular
• the anterior limb of the anterior commissure is defasciculated (J:84687)
• the anterior limb of the anterior commissure is defasciculated (J:84687)





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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory