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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Itga2btm1(GFP/cre)Emam
targeted mutation 1, Nikla R Emambokus
MGI:2670210
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Itga2btm1(GFP/cre)Emam/Itga2btm1(GFP/cre)Emam involves: 129S6/SvEvTac * C57BL/6 MGI:2670217
cn2
Itga2btm1(GFP/cre)Emam/Itga2btm1(GFP/cre)Emam
Rhoatm1Csab/Rhoatm1Csab
Tg(ITGA2B)3Mako/0
Tg(Pf4-icre)Q3Rsko/0
involves: 129S6/SvEvTac * C57BL/6 MGI:5548168


Genotype
MGI:2670217
hm1
Allelic
Composition
Itga2btm1(GFP/cre)Emam/Itga2btm1(GFP/cre)Emam
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• 1.5- to 2-fold increase in myeloid colonies from E9.5 yolk sac
• increase in the number of hematopoietic progenitor cells in the yolk sac, fetal liver, and bone marrow
• 1.5-fold increase in colony forming unit numbers and colony size from adult spleen cells
• observed in some mice due to a bleeding tendancy
• thrombocytopenia is some mice
• 1.5- to 2-fold increase in hematopoietic progenitors in the adult bone marrow
• dysfunctional platelets

homeostasis/metabolism
• dysfunctional platelets

cellular
• adhesion of bone marrow cells to fibronectin is impaired

embryo
• 1.5- to 2-fold increase in myeloid colonies from E9.5 yolk sac




Genotype
MGI:5548168
cn2
Allelic
Composition
Itga2btm1(GFP/cre)Emam/Itga2btm1(GFP/cre)Emam
Rhoatm1Csab/Rhoatm1Csab
Tg(ITGA2B)3Mako/0
Tg(Pf4-icre)Q3Rsko/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itga2btm1(GFP/cre)Emam mutation (0 available); any Itga2b mutation (0 available)
Rhoatm1Csab mutation (0 available); any Rhoa mutation (75 available)
Tg(ITGA2B)3Mako mutation (0 available)
Tg(Pf4-icre)Q3Rsko mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• cultured megakaryocytes derived from fetal liver E13.5 exhibit altered ploidy distribution (modal ploidy 16N compared with normal 2N) and larger size compared with control cells
• megakaryocytes are stiffer than in control cells
• in vivo platelet production is impaired

cellular
• in vivo platelet production is impaired





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/31/2020
MGI 6.15
The Jackson Laboratory