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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Prdx6tm1Pgn
targeted mutation 1, Beverly Paigen
MGI:2668338
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Prdx6tm1Pgn/Prdx6tm1Pgn either: 129/Sv or (involves: 129/Sv * C57BL/6) MGI:2674958


Genotype
MGI:2674958
hm1
Allelic
Composition
Prdx6tm1Pgn/Prdx6tm1Pgn
Genetic
Background
either: 129/Sv or (involves: 129/Sv * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prdx6tm1Pgn mutation (3 available); any Prdx6 mutation (46 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• in mice injected intraperitoneally with paraquat to induce oxidative stress
• severe hemorrhaging seen on the surface and interior of lungs both grossly and microscopically
• severe hemorrhaging seen in the kidneys microscopically
• severe hemorrhaging seen on the surface and interior of the liver both grossly and microscopically

cellular
• diffuse pulmonary necrosis
• lung epithelial necrosis
• in mice injected intraperitoneally with paraquat to induce oxidative stress
• increased susceptibility to oxidative stress
• 75% death rate in 3-4 days when on a B6 and 129 background
• 50% death rate when on a 129 background

renal/urinary system
• severe hemorrhaging seen in the kidneys microscopically
• in mice injected intraperitoneally with paraquat to induce oxidative stress
• swollen glomeruli
• capillaries of glomeruli congested
• contain protein casts indicative of increased capillary permeability
• epithelial cells of renal tubules degenerate
• renal tubules contain protein casts indicative of increased capillary permeability

respiratory system
• severe hemorrhaging seen on the surface and interior of lungs both grossly and microscopically
• in mice injected intraperitoneally with paraquat to induce oxidative stress
• diffuse pulmonary necrosis
• lung epithelial necrosis
• collapsed alveolar ducts

homeostasis/metabolism
• in mice injected intraperitoneally with paraquat to induce oxidative stress
• thromboses in bronchial veins
• thrombi common in veins of kidney

liver/biliary system
• severe hemorrhaging seen on the surface and interior of the liver both grossly and microscopically





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/18/2022
MGI 6.17
The Jackson Laboratory