Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grik5tm1Cont mutation
(0 available);
any
Grik5 mutation
(50 available)
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nervous system
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• heterosynaptic kainite receptor-mediated facilitation resulting from the spillover of glutamate from CA3 collateral synapses is absent
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• facilitation of mossy-fiber EPSCs by low kainate concentrations is absent
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• the half-decay of the postsynaptic kainate-mediated EPSC is shorter
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grik4tm1.1Sfh mutation
(0 available);
any
Grik4 mutation
(48 available)
Grik5tm1Cont mutation
(0 available);
any
Grik5 mutation
(50 available)
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nervous system
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• kainic acid fails to induce increases in excitatory postsynaptic current (EPSC) amplitudes unlike in similarly treated wild-type mice
• however, mice respond normally to high concentrations of kainic acid and kainate receptor-mediated inhibition of slow afterhyperpolarization current is normal
• following application with GYKI 53655, no cells exhibit GYKI-resistant EPSC unlike in similarly treated wild-type mice
• following application with GYKI 53655 and short trains of high-frequency stimulation, no GYKI-resistant EPSC is detected unlike in similarly treated wild-type mice
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• at the shortest interstimulus interval, paired-pulse facilitation is impaired compared to in similarly treated wild-type mice
• however, frequency facilitation is intact
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homeostasis/metabolism
Analysis Tools