Mouse Genome Informatics
phenotype observed in females
phenotype observed in males
N normal phenotype
• often exhibit scratching behavior suggestive of chronic pruritus

hematopoietic system
• large number of mast cells are present around the lesions

immune system
• large number of mast cells are present around the lesions

• no growth of pelage hair throughout life
• mice become completely hairless and smooth skinned in adulthood
• curly juvenile hair begins to appear thinly over the body starting at 5 days of age; lose juvenile hair progressively with age and become hairless by 12 weeks of age
• some hair follicle cysts filled with eosinophilic mass appear in the hypodermis within a few days after birth and increase in number and size until the 12th week of age
• thin vibrissae
• crooked vibrissae
• vibrissae are lost at around 12 weeks of age
• thickness of the dermis is increased due to proliferation of inflammatory cells and collagen bundles
• epidermis adjacent to lesions shows hyperkeratosis
• in regions of lesions
• in regions of lesions
• epidermis shows desquamation, with separation from the basal layer
• develop ulcerative skin lesions starting at 10 weeks of age

Mouse Models of Human Disease
Dermatitis, Atopic 603165 J:43274