All Phenotypes Tg(Foxa3-cre)1Khk MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(Foxa3-cre)1Khk
transgene insertion 1, Klaus H Kaestner
MGI:2664968

Summary

8 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Sox17^tm1Jaw/Sox17^tm1Sjm Tg(Foxa3-cre)1Khk/0	involves: 129 * C57BL/6 * DBA	MGI:4356148
cn2	Foxa2^tm1Khk/Foxa2^tm1Khk Tg(Foxa3-cre)1Khk/0	involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA	MGI:3700827
cn3	Cdk5rap3^{tm1c(EUCOMM)Hmgu}/Cdk5rap3^{tm1c(EUCOMM)Hmgu} Tg(Foxa3-cre)1Khk/0	involves: 129S4/SvJaeSor * C57BL/6N * DBA	MGI:6295910
cn4	Klf4^tm1Khk/Klf4^tm1Khk Tg(Foxa3-cre)1Khk/0	involves: 129S6/SvEvTac * C57BL/6 * DBA	MGI:3700826
cn5	Sox17^tm1Jaw/Sox17^tm1Jaw Tg(Foxa3-cre)1Khk/0	involves: 129S6/SvEvTac * C57BL/6 * DBA	MGI:4356147
cn6	Hhex^tm1Cwb/Hhex^tm2Cwb Tg(Foxa3-cre)1Khk/?	involves: 129X1/SvJ * C57BL/6 * DBA * SJL	MGI:3721922
cn7	Tg(Erbb2*)#Maed/0 Tg(Foxa3-cre)1Khk/0	involves: C57BL/6 * C57BL/6J * DBA	MGI:6192631
cn8	Cdx2^tm1Khk/Cdx2^tm1Khk Tg(Foxa3-cre)1Khk/0	involves: C57BL/6 * DBA * SJL	MGI:3848933

Allelic Composition	Sox17^tm1Jaw/Sox17^tm1Sjm Tg(Foxa3-cre)1Khk/0
Genetic Background	involves: 129 * C57BL/6 * DBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox17^tm1Jaw mutation (1 available); any Sox17 mutation (28 available)
Sox17^tm1Sjm mutation (1 available); any Sox17 mutation (28 available)
Tg(Foxa3-cre)1Khk mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal bile duct development ( J:151981 )

• at E9.5, Ipfl (Pdx1)+ cells are found throughout the liver bud unlike in control mice

• at E10.5, the biliary/gall bladder primordium is absent unlike in control mice

• however, cell proliferation and apoptosis rates are normal

liver/biliary system

abnormal bile duct development ( J:151981 )

• at E9.5, Ipfl (Pdx1)+ cells are found throughout the liver bud unlike in control mice

• at E10.5, the biliary/gall bladder primordium is absent unlike in control mice

• however, cell proliferation and apoptosis rates are normal

Allelic Composition	Foxa2^tm1Khk/Foxa2^tm1Khk Tg(Foxa3-cre)1Khk/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxa2^tm1Khk mutation (1 available); any Foxa2 mutation (26 available)
Tg(Foxa3-cre)1Khk mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:96332 )

• most die by P3, with a few surviving to P5

growth/size/body

decreased body size ( J:96332 )

endocrine/exocrine glands

decreased pancreatic alpha cell number ( J:96332 )

• the number of mature glucagon-positive pancreatic alpha-cells is reduced

disorganized pancreatic islets ( J:96332 )

• islets are irregularly shaped and display a disorganized architecture with many small clusters of endocrine cells embedded in the exocrine tissue

homeostasis/metabolism

hypoglycemia ( J:96332 )

• severely hypoglycemic

decreased circulating glucagon level ( J:96332 )

• 50% reduction of plasma glucagon

integument

decreased skin turgor ( J:96332 )

Allelic Composition	Cdk5rap3^{tm1c(EUCOMM)Hmgu}/Cdk5rap3^{tm1c(EUCOMM)Hmgu} Tg(Foxa3-cre)1Khk/0
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6N * DBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdk5rap3^{tm1c(EUCOMM)Hmgu} mutation (0 available); any Cdk5rap3 mutation (20 available)
Tg(Foxa3-cre)1Khk mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:272566 )

• mice began to die after weaning

• however, supplementation with glucose after weaning rescues come mortality

liver/biliary system

abnormal hepatic cord morphology ( J:272566 )

• defective at 1 months with disorganized tubular structures extending away from portal tracts

• however, parenchyma organization at 0.5 months is normal

abnormal hepatocyte morphology ( J:272566 )

• smaller cell area at 1 month of age

• reduced hepatocyte maturation

small liver ( J:272566 )

decreased liver weight ( J:272566 )

liver hypoplasia ( J:272566 )

abnormal hepatocyte physiology ( J:272566 )

• hepatocytes exhibit perturbed endoplasmic reticulum homeostasis (increased ER stress and activated unfolded protein response) compared with control cells

homeostasis/metabolism

increased circulating bilirubin level ( J:272566 )

decreased fasting circulating glucose level ( J:272566 )

hypoglycemia ( J:272566 )

• at 1 month of age in fasted and fed mice

decreased circulating cholesterol level ( J:272566 )

decreased circulating triglyceride level ( J:272566 )

increased circulating alanine transaminase level ( J:272566 )

• however, serum aspartate transaminase levels are normal

growth/size/body

decreased body weight ( J:272566 )

• from 1 week of age

Allelic Composition	Klf4^tm1Khk/Klf4^tm1Khk Tg(Foxa3-cre)1Khk/0
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * DBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Klf4^tm1Khk mutation (1 available); any Klf4 mutation (24 available)
Tg(Foxa3-cre)1Khk mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

abnormal stomach mucosa morphology ( J:97350 )

• polypoid lesions of the mucosa are present at 1 year of age, but no inflammation, dysplasia, or malignancies are seen in the gastric epithelia at any time

abnormal gastric gland morphology ( J:97350 )

• by 6 months of age, exhibit severe distortion of gastric pit glands

• number of pit cells is increased about 2-fold

abnormal gastric chief cell morphology ( J:97350 )

• mature zymogenic cells are decreased by more than 50%

abnormal gastric parietal cell morphology ( J:97350 )

• 50% decrease in the number of parietal cells

abnormal gastric surface mucous cell morphology ( J:97350 )

• starting at 2 weeks of age, begin to show mucous cell hyperplasia

abnormal mucous neck cell morphology ( J:97350 )

• number of mucous neck cells per gland is increased 4-fold

abnormal stomach epithelium morphology ( J:97350 )

• exhibit increased proliferation and altered differentiation of the gastric epithelia

gastric hypertrophy ( J:97350 )

• show progressive gastric hypertrophy beginning at 2 weeks of age

neoplasm

preneoplasia ( J:97350 )

• mutants display aberrant expression of acidic mucins and TFF2/SP-positive cells, indicative of premalignant conditions, but no inflammation, intestinal metaplasia, dysplasia, or cancer up to 1 year of age

endocrine/exocrine glands

abnormal gastric gland morphology ( J:97350 )

• by 6 months of age, exhibit severe distortion of gastric pit glands

• number of pit cells is increased about 2-fold

abnormal gastric chief cell morphology ( J:97350 )

• mature zymogenic cells are decreased by more than 50%

abnormal gastric parietal cell morphology ( J:97350 )

• 50% decrease in the number of parietal cells

abnormal mucous neck cell morphology ( J:97350 )

• number of mucous neck cells per gland is increased 4-fold

Allelic Composition	Sox17^tm1Jaw/Sox17^tm1Jaw Tg(Foxa3-cre)1Khk/0
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * DBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox17^tm1Jaw mutation (1 available); any Sox17 mutation (28 available)
Tg(Foxa3-cre)1Khk mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal bile duct development ( J:151981 )

• at E9.5, Ipfl (Pdx1)+ cells are found throughout the liver bud unlike in control mice

• at E10.5, the biliary/gall bladder primordium is absent unlike in control mice

• however, cell proliferation and apoptosis rates are normal

abnormal common bile duct morphology ( J:151981 )

• at E16.5, 50% of mice exhibit ectopic pancreatic tissue in the common duct unlike control mice

absent gallbladder ( J:151981 )

• at E16.5

liver/biliary system

abnormal bile duct development ( J:151981 )

• at E9.5, Ipfl (Pdx1)+ cells are found throughout the liver bud unlike in control mice

• at E10.5, the biliary/gall bladder primordium is absent unlike in control mice

• however, cell proliferation and apoptosis rates are normal

abnormal common bile duct morphology ( J:151981 )

• at E16.5, 50% of mice exhibit ectopic pancreatic tissue in the common duct unlike control mice

absent gallbladder ( J:151981 )

• at E16.5

Allelic Composition	Hhex^tm1Cwb/Hhex^tm2Cwb Tg(Foxa3-cre)1Khk/?
Genetic Background	involves: 129X1/SvJ * C57BL/6 * DBA * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hhex^tm1Cwb mutation (0 available); any Hhex mutation (16 available)
Hhex^tm2Cwb mutation (1 available); any Hhex mutation (16 available)
Tg(Foxa3-cre)1Khk mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:124126 )

liver/biliary system

abnormal extrahepatic bile duct morphology ( J:124126 )

• at E13.5, the extrahepatic bile duct (EHBD) is absent and normal EHBD epithelium is replaced by pseudostratified epithelium resembling the duodenum

• at E16.5, the duodenal-like mucosa extends from the duodenum to the liver hilum

abnormal hepatic duct morphology ( J:124126 )

• at E16.5, dilated hepatic ducts and biliary cysts lined by cuboidal epithelium are present at the liver hilum

biliary cyst ( J:124126 )

• at E16.5, biliary cysts are present at the liver hilum

absent gallbladder ( J:124126 )

• at E10.5, gall bladder primordium could not be detected by Onecut1 staining

abnormal liver morphology ( J:124126 )

• at E16.5, the ventral liver periphery has lost its cohesive structure and bloods cells are trapped or pool in this region

• at E18.5, normal hepatic architecture is disrupted

abnormal intrahepatic bile duct morphology ( J:124126 )

• at E18.5, livers exhibit large dilated duct-like structures

liver cyst ( J:124126 )

• at E18.5, livers are extremely cystic with large dilated duct-like structures and many smaller cysts

liver hypoplasia ( J:124126 )

• at E13.5, the liver is hypoplastic

endocrine/exocrine glands

abnormal extrahepatic bile duct morphology ( J:124126 )

• at E13.5, the extrahepatic bile duct (EHBD) is absent and normal EHBD epithelium is replaced by pseudostratified epithelium resembling the duodenum

• at E16.5, the duodenal-like mucosa extends from the duodenum to the liver hilum

abnormal hepatic duct morphology ( J:124126 )

• at E16.5, dilated hepatic ducts and biliary cysts lined by cuboidal epithelium are present at the liver hilum

abnormal intrahepatic bile duct morphology ( J:124126 )

• at E18.5, livers exhibit large dilated duct-like structures

biliary cyst ( J:124126 )

• at E16.5, biliary cysts are present at the liver hilum

absent gallbladder ( J:124126 )

• at E10.5, gall bladder primordium could not be detected by Onecut1 staining

growth/size/body

biliary cyst ( J:124126 )

• at E16.5, biliary cysts are present at the liver hilum

liver cyst ( J:124126 )

• at E18.5, livers are extremely cystic with large dilated duct-like structures and many smaller cysts

Allelic Composition	Tg(Erbb2*)#Maed/0 Tg(Foxa3-cre)1Khk/0
Genetic Background	involves: C57BL/6 * C57BL/6J * DBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Erbb2*)#Maed mutation (0 available)
Tg(Foxa3-cre)1Khk mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:262746 )

• most mice die within 10 weeks after birth

neoplasm

increased pancreas tumor incidence ( J:262746 )

• papillary epithelial cells show dysplasia of low- to high-grades, resembling human intraductal papillary mucinous neoplasm with focal high-grade dysplasia

digestive/alimentary system

abnormal pancreatic acinar cell morphology ( J:262746 )

• loss of acinar cells in the pancreatic parenchyma, broad cystic changes, and elevated papillary lesions

endocrine/exocrine glands

abnormal pancreas morphology ( J:262746 )

• mice develop cystic lesions exhibiting papillary proliferation in almost all pancreatic tissue at 8 weeks of age

abnormal pancreatic acinar cell morphology ( J:262746 )

• loss of acinar cells in the pancreatic parenchyma, broad cystic changes, and elevated papillary lesions

increased pancreas tumor incidence ( J:262746 )

• papillary epithelial cells show dysplasia of low- to high-grades, resembling human intraductal papillary mucinous neoplasm with focal high-grade dysplasia

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
benign neoplasm		DOID:0060072		J:262746

Allelic Composition	Cdx2^tm1Khk/Cdx2^tm1Khk Tg(Foxa3-cre)1Khk/0
Genetic Background	involves: C57BL/6 * DBA * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdx2^tm1Khk mutation (0 available); any Cdx2 mutation (22 available)
Tg(Foxa3-cre)1Khk mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:149479 )

• mice die by P1

digestive/alimentary system

abnormal digestive system development ( J:149479 )

• at E14.5, mice exhibit a progressive defects in elongation compared with wild-type mice

• at E14.5, distal intestine contains a dilated gut lumen unlike in wild-type mice

abnormal hindgut morphology ( J:149479 )

• posterior gut region abnormalities are evident as early as E12.5

abnormal enteroendocrine cell morphology ( J:149479 )

• terminal differentiation is severely impaired

abnormal intestine morphology ( J:149479 )

• the intestine ends in an abnormal distal structure that terminates in a blind-sac

• mice exhibit intestinal obstruction unlike in wild-type mice

• at E16.5, mice exhibit a severe shortening of the intestine unlike in wild-type mice

• the posterior intestine is anteriorized

abnormal intestinal goblet cell morphology ( J:149479 )

• terminal differentiation is severely impaired

abnormal intestinal epithelium morphology ( J:149479 )

• proximal and medial intestinal epithelia is less organized compared to in wild-type mice

• the cuboidal epithelia of the jejunum and ileum is replaced with a flattened epithelium

• duodenum epithelial cell proliferation is increased more than 20% compared to in wild-type mice

• however, apoptosis rates of duodenum epithelial cells are normal

• differentiation of gastric glandular epithelial cells cannot be detected

• posterior intestinal epithelial cells contain tonofilaments unlike in wild-type cells

absent enterocytes ( J:149479 )

• terminal differentiation is severely impaired

abnormal cecum morphology ( J:149479 )

• the mutant ileum and cecum lack villi entirely

absent colon ( J:149479 )

• no colon forms

abnormal duodenum morphology ( J:149479 )

• the duodenum contains villus-like epithelial foldings that are stunted and broadened compared to in wild-type mice

• duodenum epithelial cell proliferation is increased more than 20% compared to in wild-type mice

• however, apoptosis rates of duodenum epithelial cells are normal

distended duodenum ( J:149479 )

• the duodenum becomes progressively distended and translucent likely due to fluid retention caused by distal obstruction

• by E18.5, the duodenum is dilated 5- to 7-fold compared to in wild-type mice

decreased small intestinal villus size ( J:149479 )

• the mutant ileum and cecum lack villi entirely

• at E18.5, reduced villus increases in severity from anterior to posterior

• at E16.5, mice exhibit villus hypoplasia

cellular

abnormal intestinal goblet cell morphology ( J:149479 )

• terminal differentiation is severely impaired

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