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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fcgr1tm1Jsv
targeted mutation 1, J Sjef Verbeek
MGI:2664927
Summary 3 genotypes


Genotype
MGI:2664932
hm1
Allelic
Composition		 Fcgr1tm1Jsv/Fcgr1tm1Jsv
Genetic
Background		 involves: 129P2/OlaHsd * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcgr1tm1Jsv mutation (4 available); any Fcgr1 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to autoimmune hemolytic anemia ( J:83995 )
• decreased autoimmune hemolytic anemia when induced with mouse IgG2a
abnormal macrophage physiology ( J:83995 )
• antibody-dependent cell-mediated cytotoxicity (ADCC) of macrophages toward tumor cell lines is impaired
abnormal dendritic cell antigen presentation ( J:83995 )
• deficient antigen presentation by bone marrow dendritic cells
abnormal type I hypersensitivity reaction ( J:83995 )
• the systemic anaphylaxis response after passive sensitization with IgG2a is modified and attenuated and mortality is decreased after challenge
decreased susceptibility to induced arthritis ( J:83995 )
• reduced cartilage damage during experimentally antigen-induced arthritis
increased susceptibility to bacterial infection ( J:83995 )
• impaired clearance of B. pertussi bacterial infection

hematopoietic system
decreased susceptibility to autoimmune hemolytic anemia ( J:83995 )
• decreased autoimmune hemolytic anemia when induced with mouse IgG2a
abnormal macrophage physiology ( J:83995 )
• antibody-dependent cell-mediated cytotoxicity (ADCC) of macrophages toward tumor cell lines is impaired

skeleton
decreased susceptibility to induced arthritis ( J:83995 )
• reduced cartilage damage during experimentally antigen-induced arthritis




Genotype
MGI:3851204
cx2
Allelic
Composition		 Fcer1atm1Knt/Fcer1atm1Knt
Fcer2atm1Max/Fcer2atm1Max
Fcgr1tm1Jsv/Fcgr1tm1Jsv
Fcgr2btm1Ttk/Fcgr2btm1Ttk
Fcgr3tm1Jsv/Fcgr3tm1Jsv
Genetic
Background		 B6.Cg-Fcgr2btm1Ttk Fcgr3tm1Jsv Fcer1atm1Knt Fcgr1tm1Jsv Fcer2atm1Max
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcer1atm1Knt mutation (3 available); any Fcer1a mutation (21 available)
Fcer2atm1Max mutation (0 available); any Fcer2a mutation (24 available)
Fcgr1tm1Jsv mutation (4 available); any Fcgr1 mutation (34 available)
Fcgr2btm1Ttk mutation (7 available); any Fcgr2b mutation (49 available)
Fcgr3tm1Jsv mutation (5 available); any Fcgr3 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal mast cell physiology ( J:144620 )
• mast cells fail to react and initiate an airway inflammatory response when IgE immune complexes are administered intranasally
• mice are able to react to IgE complexes one day after administration of supernatants collected from activated mast cells
abnormal macrophage physiology ( J:144620 )
• macrophages fail to react to IgE complexes
increased susceptibility to type I hypersensitivity reaction ( J:144620 )
• mice fail to initiate an airway inflammatory response when IgE immune complexes are administered intranasally

hematopoietic system
abnormal mast cell physiology ( J:144620 )
• mast cells fail to react and initiate an airway inflammatory response when IgE immune complexes are administered intranasally
• mice are able to react to IgE complexes one day after administration of supernatants collected from activated mast cells
abnormal macrophage physiology ( J:144620 )
• macrophages fail to react to IgE complexes




Genotype
MGI:2664970
cx3
Allelic
Composition		 Fcgr1tm1Jsv/Fcgr1tm1Jsv
Fcgr2btm1Ttk/Fcgr2btm1Ttk
Fcgr3tm1Jsv/Fcgr3tm1Jsv
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcgr1tm1Jsv mutation (4 available); any Fcgr1 mutation (34 available)
Fcgr2btm1Ttk mutation (7 available); any Fcgr2b mutation (49 available)
Fcgr3tm1Jsv mutation (5 available); any Fcgr3 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
impaired macrophage phagocytosis ( J:83995 )
• phagocytosis of all IgG-IC by macrophages is abrogated

hematopoietic system
impaired macrophage phagocytosis ( J:83995 )
• phagocytosis of all IgG-IC by macrophages is abrogated

cellular
impaired macrophage phagocytosis ( J:83995 )
• phagocytosis of all IgG-IC by macrophages is abrogated




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory