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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ica1tm1Mdos
targeted mutation 1, H Michael Dosch
MGI:2662437
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ica1tm1Mdos/Ica1tm1Mdos involves: 129S1/Sv * 129X1/SvJ MGI:3831658
hm2
Ica1tm1Mdos/Ica1tm1Mdos NOD.129-Ica1tm1Mdos MGI:2662441
cx3
Ica1tm1Mdos/Ica1tm1Mdos
Ica1lem1Jxia/Ica1lem1Jxia
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA MGI:5806228


Genotype
MGI:3831658
hm1
Allelic
Composition
Ica1tm1Mdos/Ica1tm1Mdos
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ica1tm1Mdos mutation (1 available); any Ica1 mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mutants have no obvious phenotype and age normally

reproductive system
N
• mice exhibit normal fertility with no significant difference in total, mobile and linear mobile sperm




Genotype
MGI:2662441
hm2
Allelic
Composition
Ica1tm1Mdos/Ica1tm1Mdos
Genetic
Background
NOD.129-Ica1tm1Mdos
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ica1tm1Mdos mutation (1 available); any Ica1 mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• a subset of females die spontaneously without prodromal symptoms around 4-5 months of age

homeostasis/metabolism
• diabetes develops around 20 weeks of age, 4 weeks later than wild-type NOD mice

immune system
• mutants fail to generate, even after immunization, cross-reactive T cells that recognize the dominant Tep69 epitope in Ica1, and the ABBOS epitope in BSA
• although mutants develop diabetes at around 20 weeks of age, this is 4 weeks later than wild-type NOD mice
• mutants are resistant to cyclophosphamide-accelerated diabetes

hematopoietic system
• mutants fail to generate, even after immunization, cross-reactive T cells that recognize the dominant Tep69 epitope in Ica1, and the ABBOS epitope in BSA




Genotype
MGI:5806228
cx3
Allelic
Composition
Ica1tm1Mdos/Ica1tm1Mdos
Ica1lem1Jxia/Ica1lem1Jxia
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ica1lem1Jxia mutation (0 available); any Ica1l mutation (18 available)
Ica1tm1Mdos mutation (1 available); any Ica1 mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• severe reduction in total and mobile sperm number with complete loss of linear mobile sperm
• in cauda epididymis
• fragmented or completely lost
• in some sperm
• smaller and irregular compared with wild-type sperm
• with round nuclei sperm

cellular
• severe reduction in total and mobile sperm number with complete loss of linear mobile sperm
• in cauda epididymis
• fragmented or completely lost
• in some sperm
• smaller and irregular compared with wild-type sperm





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/18/2022
MGI 6.17
The Jackson Laboratory