Phenotypes associated with this allele

• Allele Symbol: Rtn4^tm2Matl
• Allele Name: targeted mutation 2, Marc Tessier-Lavigne
• Allele ID: MGI:2661167
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rtn4^tm2Matl/Rtn4^tm2Matl	involves: 129S7/SvEvBrd * C57BL/6	MGI:2661220

Genotype
MGI:2661220

hm1

• Allelic Composition: Rtn4^tm2Matl/Rtn4^tm2Matl
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:83192 )

• lethality prior to E9.5, (C57BL/6 x 129S7)F1 intercross

• a single viable mutant was obtained from an F1 x chimera cross and used to establish several lines that produced viable homozygotes (though less than expected by mendelian ratios)

nervous system

nervous system phenotype ( J:83192 )

N • spinal regeneration was assessed in viable mice and was not enhanced relative to wild-type