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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Arg1tm1Rki
targeted mutation 1, Ramaswamy K Iyer
MGI:2660809
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Arg1tm1Rki/Arg1tm1Rki Not Specified MGI:2668857


Genotype
MGI:2668857
hm1
Allelic
Composition
Arg1tm1Rki/Arg1tm1Rki
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arg1tm1Rki mutation (1 available); any Arg1 mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• die at postnatal day 10-14

homeostasis/metabolism
• total kidney arginase activity levels normal; ARG2 levels are thought to be induced two-fold in these mice
• elevated plasma arginine levels: four fold greater than the level of wild-type
• reduced plasma proline levels: one third of the level of wild-type
• reduced plasma ornithine levels: one half of the level of wild-type
• elevated plasma glutamic acid, citrulline and histidine levels: about 1.5 fold greater than the wild-type level
• reduced plasma valine, isoleucine and leucine levels: 0.4 to 0.5 of the level of wild-type
• plasma ammonia levels are increased 10 fold in mice exhibiting metabolic crisis

liver/biliary system
• nuclei and cytoplasm enlarged two to three fold in most cells; cytoplasmic inclusions also noted as well as other abnormalities; abnormal nuclei

nervous system
N
• normal brain morphology; no astrocyte defects noted

Mouse Models of Human Disease
OMIM ID Ref(s)
Argininemia 207800 J:83263





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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory