Phenotypes associated with this allele

• Allele Symbol: Nr1i3^tm1Ddm
• Allele Name: targeted mutation 1, David D Moore
• Allele ID: MGI:2657124
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nr1i3^tm1Ddm/Nr1i3^tm1Ddm	C3.129S7-Nr1i3^tm1Ddm	MGI:3055751
hm2	Nr1i3^tm1Ddm/Nr1i3^tm1Ddm	involves: 129S7/SvEvBrd * C57BL/6	MGI:2657125
cx3	Nr1i3^tm1Ddm/Nr1i3^tm1Ddm Tg(Alb1-NR1I3)1Ddm/0	involves: 129S7/SvEvBrd * C57BL/6	MGI:2657137

Genotype
MGI:3055751

hm1

• Allelic Composition: Nr1i3^tm1Ddm/Nr1i3^tm1Ddm
• Genetic Background: C3.129S7-Nr1i3^tm1Ddm

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating glucose level ( J:92777 )

• phenobarbital treatment induces increased serum glucose levels in mutant but not wild-type mice

Genotype
MGI:2657125

hm2

• Allelic Composition: Nr1i3^tm1Ddm/Nr1i3^tm1Ddm
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

homeostasis/metabolism

abnormal response/metabolism to endogenous compounds ( J:82748 )

• defective clearance of chronically elevated bilirubin levels

decreased physiological sensitivity to xenobiotic ( J:65416 , J:82748 , J:83102 )

• resistant to hepatomegaly and induction of DNA synthesis when treated with phenobarbital or TCPOBOP (J:65416)

• cocaine does not cause acute hepatotoxicity in mutants exposed to phenobarbital or TCPOBOP as it does in wild-type mice (J:65416)

• zoxazolamine, a muscle relaxant, causes paralysis in mice, however pretreatment with Phenobarbital or TCPOBOP prevents the paralysis in wild-type mice but not in mutants, indicating that mutants have a decreased response to Phenobarbital or TCPOBOP after treatment with zoxazolamine (J:65416)

• pretreatment with xenobiotic inducers, phenobarbital or TCPOBOP, increases the rate of clearance of an exogenous bilirubin load in wild-type but not mutant mice (J:82748)

• mice treated with phenobarbital or TCPOBOP plus acetaminophen are resistant to the formation of hepatotoxicity (J:83102)

• mutants are resistant to toxic doses of acetaminophen (J:83102)

Genotype
MGI:2657137

cx3

• Allelic Composition: Nr1i3^tm1Ddm/Nr1i3^tm1Ddm; Tg(Alb1-NR1I3)1Ddm/0
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

homeostasis/metabolism

increased physiological sensitivity to xenobiotic ( J:83102 )

• mutants treated with phenobarbital exhibit increased sensitivity to acetaminophen